Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Max N. Moore"'
Autor:
Phil Olsen, R. Krishna Kumar, Lucio Mendez, Anthony N. Scozzari, Max N. Moore, Zhiwei Wang, Recaldo L. Carty, Vasulinga T. Ravikumar, Isaiah Cedillo, Ratnasamy Somanathan, Xue-Feng Zhu, Mark Andrade, Gerardo Aguirre, Dennis Gorman, Sylvain Berneès
Publikováno v:
Organic Process Research & Development. 12:399-410
A novel universal linker (UnyLinker) molecule which has a conformationally rigid and chemically stable bridge head ring oxygen atom carrying a conventional 4,4′-dimethoxytrityl (DMT) and succinyl groups locked in a syn orientation has been develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61eba3b555143a18b1ed64c45af03ba5
https://doi.org/10.1021/op8000178
https://doi.org/10.1021/op8000178
Autor:
Hans Gaus, Stella D. Decottignies, Max N. Moore, Vasulinga T. Ravikumar, Brett Turney, Achim H. Krotz, James V. McArdle, Anthony N. Scozzari, Daniel C. Capaldi, Recaldo L. Carty
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4683-4690
Incomplete sulfurization during solid-phase synthesis of phosphorothioate oligonucleotides using phosphoramidite chemistry was identified as the cause of formation of two new classes of process-related oligonucleotide impurities containing a DMTr-C-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48931352b7dd213f04cb38f064c47fc6
https://doi.org/10.1016/j.bmcl.2004.06.088
https://doi.org/10.1016/j.bmcl.2004.06.088
Publikováno v:
Organic Process Research & Development. 8:271-274
During solid-phase synthesis of oligonucleotides in packed-bed reactors a substantial pressure build-up is observed during acid deprotection and subsequent solvent washing as the length of the supp...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f96a5df536dc8f3e1c40b915d9743e3a
https://doi.org/10.1021/op030213j
https://doi.org/10.1021/op030213j
Autor:
Kirsten Lowery, Daniel C. Capaldi, Achim H. Krotz, Max N. Moore, Hans Gaus, Vasulinga T. Ravikumar, Anthony N. Scozzari, Ricaldo L. Carty, Jim Arnold, Douglas L. Cole
Publikováno v:
Organic Process Research & Development. 7:832-838
It is demonstrated that the acrylonitrile (AN) generated during the ammonolysis step of oligonucleotide manufacture selectively adds to thymine residue present in ISIS 2302 to give a full-length ol...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2231f3c9be23bf5a46e3f1f6736e5ba2
https://doi.org/10.1021/op020090n
https://doi.org/10.1021/op020090n
Autor:
Mark Andrade, Recaldo L. Carty, Douglas L. Cole, Max N. Moore, Claus Rentel, Quinlai Song, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
Publikováno v:
Organic Process Research & Development. 7:917-920
Efficiency of phosphorothioate oligonucleotide syntheses could be improved by increasing the concentration of dichloroacetic acid in toluene to 10% from 3% (v/v) during the detritylation step. It was also found that dichloroacetic acid is better than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae305f762fc379baa47e3a347283f6d
https://doi.org/10.1021/op030006j
https://doi.org/10.1021/op030006j
Autor:
Richard S. Geary, Tanya Watanabe, J.R. Fitchett, Arthur A. Levin, Todd Burckin, Max N. Moore, John Matson, Michael V. Templin, Janet M. Leeds, Rosie Z. Yu
Publikováno v:
Journal of Pharmaceutical Sciences. 90:182-193
The plasma pharmacokinetics and tissue disposition of ISIS 2503 were studied in mice following single and multiple bolus intravenous (iv) injections of 1–50 mg/kg, and in monkeys following single and multiple 2‐h iv infusions of 1–10 mg/kg and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2178eed6a536ddff6dda7571e318a9
https://doi.org/10.1002/1520-6017(200102)90:2<182::aid-jps9>3.0.co
https://doi.org/10.1002/1520-6017(200102)90:2<182::aid-jps9>3.0.co
Autor:
Zacharia S. Cheruvallath, Brett Turney, Hans Gaus, Vasulinga T. Ravikumar, Achim H. Krotz, Anthony N. Scozzari, and Douglas L. Cole, Daniel C. Capaldi, Stephen R. Craig, Recaldo L. Carty, Patrick Wheeler, Max N. Moore
Publikováno v:
Organic Process Research & Development. 4:199-204
It is demonstrated that phosphorothioate oligodeoxyribonucleotides can be synthesized on scales from 1 μmol to 150 mmol using phenylacetyl disulfide (PADS) as an efficient and economical replacemen...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e970352d578d58f7c57c74c0d4f4474
https://doi.org/10.1021/op990077b
https://doi.org/10.1021/op990077b
Autor:
Douglas L. Cole, Max N. Moore, Achim H. Krotz, Anthony N. Scozzari, Recaldo L. Carty, Vasulinga T. Ravikumar
Publikováno v:
Green Chemistry. 1:277-282
It is demonstrated that mixed-sequence phosphorothioate oligodeoxyribonucleotides can be synthesized on scales up to 80 mmol without using chlorinated solvents like dichloromethane, while preserving both high yield and purity of the product. A soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61be9163cc908ceb47e2ff01ecea6dfe
https://doi.org/10.1039/a907685i
https://doi.org/10.1039/a907685i
Autor:
Douglas D. Koch, Giuseppe L Valderamma, Richard F. Menefee, Perry S. Binder, Michael J. Berry, Thomas Kohnen, Max N. Moore, Janet A. Anderson
Publikováno v:
Publons
BACKGROUND: Noncontact holmium:YAG laser thermal keratoplasty (Ho:YAG LTK) is a promising new technology for correction of hyperopia and astigmatism. We studied the acute histologic changes and wound healing response following Ho:YAG LTK performed wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbcfbd2f5ee9bc7acfc8040b4813c0d1
https://doi.org/10.3928/1081-597x-19960701-16
https://doi.org/10.3928/1081-597x-19960701-16
Publikováno v:
Archives of Ophthalmology, 113, pp. 1124-1130
Archives of Ophthalmology, 113, 9, pp. 1124-1130
Archives of Ophthalmology, 113, 1124-1130
Archives of Ophthalmology, 113, 9, pp. 1124-1130
Archives of Ophthalmology, 113, 1124-1130
Objective: To evaluate epithelial-stromal interactions in the healing of stromal wounds and the relationship of such interactions to regional variations in healing throughout keratotomy wounds. Methods: Ten radial keratotomy autopsy specimens were st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d668145250789d90b50d445244c71208
https://repository.ubn.ru.nl/handle/2066/255882
https://repository.ubn.ru.nl/handle/2066/255882
