Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Max Levin"'
Autor:
Berit Carow, Victoria Muliadi, Kristina Skålén, Chika Yokota, Gokul Raj Kathamuthu, Todia Pediatama Setiabudiawan, Christoph Lange, Katrin Scheu, Karoline I. Gaede, Torsten Goldmann, Ankur Pandita, Kiran Iqbal Masood, Shahid Pervez, Johan Grunewald, Zahra Hasan, Max Levin, Martin E. Rottenberg
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here, we compared the immunological microenvironments of granulomas from TB and sarcoidosis patients using in situ sequencing (ISS) transcriptomic analysis and multiplexed immunolabel
Externí odkaz:
https://doaj.org/article/e50ca85cbb8f49688503a2602e0ba284
Autor:
Sara Bjursten, Zhiyuan Zhao, Hifaa Al Remawi, Marie Studahl, Ankur Pandita, Joel Simrén, Henrik Zetterberg, Anna-Carin Lundell, Anna Rudin, Lars Ny, Max Levin
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104955- (2024)
Summary: Background: Cancer treatment with immune checkpoint inhibition (ICI) can cause immune-related adverse events in the central nervous system (CNS irAE). There are no blood biomarkers to detect CNS irAE. We investigated if concentrations of S10
Externí odkaz:
https://doaj.org/article/332878addbdc4ac9a9941e3380030091
Autor:
Lars Ny, Henrik Jespersen, Joakim Karlsson, Samuel Alsén, Stefan Filges, Charlotta All-Eriksson, Bengt Andersson, Ana Carneiro, Hildur Helgadottir, Max Levin, Ingrid Ljuslinder, Roger Olofsson Bagge, Vasu R. Sah, Ulrika Stierner, Anders Ståhlberg, Gustav Ullenhag, Lisa M. Nilsson, Jonas A. Nilsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The authors report the results of the phase II PEMDAC clinical study testing the combination of the HDAC inhibitor entinostat with the anti- PD-1 antibody pembrolizumab in uveal melanoma. Low tumor burden, a wildtype BAP1 gene in the tumor or iris me
Externí odkaz:
https://doaj.org/article/81ef06cf1a674812b72c3509644a228b
Autor:
Sara Bjursten, Christoffer Vannas, Stefan Filges, Florian Puls, Ankur Pandita, Henrik Fagman, Anders Ståhlberg, Max Levin
Publikováno v:
Case Reports in Oncology, Vol 12, Iss 3, Pp 872-879 (2019)
Approximately 50% of patients with metastatic melanoma harbor an activating BRAF mutation. Tumors with activating mutation BRAF gene proliferate excessively and can be treated with targeted BRAF-inhibitors in combination with MEK inhibitors. The most
Externí odkaz:
https://doaj.org/article/4173e93fea8b411183872b332f9b3d19
Autor:
Henrik Zetterberg, Max Levin, Anna Rudin, Jan Borén, Sara Bjursten, Ankur Pandita, Zhiyuan Zhao, Charlotta Fröjd, Lars Ny, Christer Jensen, Tobias Ullerstam, Henrik Jespersen, Malin Levin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
We report a case of rapid eradication of melanoma brain metastases and simultaneous near-fatal encephalomyelitis following double immune checkpoint blockade. Brain damage marker S-100B and C reactive protein increased before symptoms or signs of ence
Externí odkaz:
https://doaj.org/article/f08d260daae4488a8cdede3b561dc292
Autor:
Henrik Jespersen, Roger Olofsson Bagge, Gustav Ullenhag, Ana Carneiro, Hildur Helgadottir, Ingrid Ljuslinder, Max Levin, Charlotta All-Eriksson, Bengt Andersson, Ulrika Stierner, Lisa M. Nilsson, Jonas A. Nilsson, Lars Ny
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-7 (2019)
Abstract Background While recent years have seen a revolution in the treatment of metastatic cutaneous melanoma, no treatment has yet been able to demonstrate any prolonged survival in metastatic uveal melanoma. Thus, metastatic uveal melanoma remain
Externí odkaz:
https://doaj.org/article/793d6ab292574ce2b8dfc4897ed38b34
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
BACKGROUND Identifying factors conferring responses to therapy in cancer is critical to select the best treatment for patients. For immune checkpoint inhibition (ICI) therapy, mounting evidence suggests that the gut microbiome can determine patient t
Externí odkaz:
https://doaj.org/article/81f6d4e2cee943b9b47bcc9990492b46
Autor:
Matias Ekstrand, Emma Widell, Anna Hammar, Levent M Akyürek, Martin Johansson, Björn Fagerberg, Göran Bergström, Malin C Levin, Per Fogelstrand, Jan Borén, Max Levin
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178877 (2017)
OBJECTIVE:Severe hypoxia develops close to the necrotic core of advanced human atherosclerotic plaques, but the energy metabolic consequences of this hypoxia are not known. In animal models, plaque hypoxia is also associated with depletion of glucose
Externí odkaz:
https://doaj.org/article/f4e22ce7eebb469b82f241cfba854040
Autor:
Matias Ekstrand, Maria Gustafsson Trajkovska, Jeanna Perman-Sundelin, Per Fogelstrand, Martin Adiels, Martin Johansson, Lillemor Mattsson-Hultén, Jan Borén, Max Levin
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130898 (2015)
The first objective was to investigate if intracellular and extracellular levels of reactive oxygen species (ROS) within the mouse aorta increase before or after diet-induced lesion formation. The second objective was to investigate if intracellular
Externí odkaz:
https://doaj.org/article/efff182aa57544f9891a77da323be6c2
Autor:
Lisa U Magnusson, Annika Lundqvist, Merja Nurkkala Karlsson, Kristina Skålén, Max Levin, Olov Wiklund, Jan Borén, Lillemor Mattsson Hultén
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43142 (2012)
Inflammation in the vascular wall is important for development of atherosclerosis. We have shown previously that arachidonate 15-lipoxygenase type B (ALOX15B) is more highly expressed in human atherosclerotic lesions than in healthy arteries. This en
Externí odkaz:
https://doaj.org/article/22e10b26dc284395a89eeeca6e8a5ad2