SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

Autor: Jakob Hartmann, Thomas Bajaj, Joy Otten, Claudia Klengel, Tim Ebert, Anne-Kathrin Gellner, Ellen Junglas, Kathrin Hafner, Elmira A. Anderzhanova, Fiona Tang, Galen Missig, Lindsay Rexrode, Daniel T. Trussell, Katelyn X. Li, Max L. Pöhlmann, Sarah Mackert, Thomas M. Geiger, Daniel E. Heinz, Roy Lardenoije, Nina Dedic, Kenneth M. McCullough, Tomasz Próchnicki, Thomas Rhomberg, Silvia Martinelli, Antony Payton, Andrew C. Robinson, Valentin Stein, Eicke Latz, William A. Carlezon, Felix Hausch, Mathias V. Schmidt, Chris Murgatroyd, Sabina Berretta, Torsten Klengel, Harry Pantazopoulos, Kerry J. Ressler, Nils C. Gassen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic moda

Externí odkaz: https://doaj.org/article/83209dbad20940cdab3e3f6f4104353f

Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs

Autor: Max L. Pöhlmann, Alexander S. Häusl, Daniela Harbich, Georgia Balsevich, Clara Engelhardt, Xixi Feng, Michaela Breitsamer, Felix Hausch, Gerhard Winter, Mathias V. Schmidt

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 12 (2018)

Despite a growing body of research over the last few decades, mental disorders, including anxiety disorders or depression, are still one of the most prevalent and hardest to treat health burdens worldwide. Since pharmacological treatment with a singl

Externí odkaz: https://doaj.org/article/0f8f2202597e4f72bdbce00673619977

FKBP51 in the Oval Bed Nucleus of the Stria Terminalis Regulates Anxiety-Like Behavior

Autor: Clara Engelhardt, Fiona Tang, Radwa Elkhateib, Joeri Bordes, Lea Maria Brix, Lotte van Doeselaar, Alexander S. Häusl, Max L. Pöhlmann, Karla Schraut, Huanqing Yang, Alon Chen, Jan M. Deussing, Mathias V. Schmidt

Publikováno v: eNeuro

Visual Abstract
The cochaperone FKBP51, encoded by the Fkbp5 gene, has been identified as central risk factor for anxiety-related disorders and stress system dysregulation. In the brain, the oval bed nucleus of the stria terminalis (ovBNST) has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2675afef4c2051a9e43a1b2eb1844cb1
http://europepmc.org/articles/PMC8687485

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice

Autor: Matthias Eder, Kathrin Hafner, Juan-Pablo Lopez, Jakob Hartmann, Thomas Bajaj, Elena Brivio, Lisa Rudolph, Hannah M Goss, Johannes M. H. M. Reul, Alexander S. Häusl, Jan M. Deussing, Rainer Stoffel, Max L. Pöhlmann, Kerry J. Ressler, Alon Chen, Simone Roeh, Nils C. Gassen, L. Brix, Danusa Menegaz, Clara Engelhardt, Mathias V. Schmidt

Publikováno v: Häusl, A S, Brix, L M, Hartmann, J, Pöhlmann, M L, Lopez, J-P, Menegaz, D, Brivio, E, Engelhardt, C, Roeh, S, Bajaj, T, Rudolph, L, Stoffel, R, Hafner, K, Goss, H M, Reul, J M H M, Deussing, J M, Eder, M, Ressler, K J, Gassen, N C, Chen, A & Schmidt, M V 2021, ' The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice ', Molecular Psychiatry, vol. 26, no. 7, pp. 3060-3076 . https://doi.org/10.1038/s41380-021-01044-x
Molecular Psychiatry

Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-adrenal (HPA) axis is a fundamental component of multiple stress-related diseases, including psychiatric, metabolic, and immune disorders. The FK506 binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6c156ba2e04e7c7fd68b81c30c850f
https://research-information.bris.ac.uk/ws/files/286507217/Full_text_PDF_final_published_version_.pdf

Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation

Autor: Felix Beuschlein, Charles B. Nemeroff, Max L. Pöhlmann, Fabian J. Theis, Mathias V. Schmidt, Anna Riester, W. Edward Craighead, Martin Fassnacht, Rainer Stoffel, Cynthia L. Andoniadou, Tanja Brückl, Clara Engelhardt, Elena Brivio, Carlo De Donno, Helen S. Mayberg, Nicolas Rost, Martin Reincke, Alina Tontsch, Miriam Peters, Javier M. Villamizar, Darina Czamara, Alon Chen, Aron Kos, Andrea Ressle, Boadie W. Dunlop, Juan Pablo Lopez, Alice Santambrogio, Elisabeth B. Binder, Simone Roeh, Silviu Sbiera

Publikováno v: Science Advances

Dissection of the HPA axis using single-cell RNA sequencing uncovers adrenal ABCB1 as an important player of stress adaptation.
Chronic activation and dysregulation of the neuroendocrine stress response have severe physiological and psychologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cac472d0a2749f11ca9c9d59a8cf0ed
https://doi.org/10.1126/sciadv.abe4497