Intercellular adhesion molecule 2 regulates diapedesis hotspots by allowing neutrophil crawling against the direction of flow

Autor: Max L B Grönloh, Merel E Tebbens, Marianthi Kotsi, Janine J G Arts, Jaap D van Buul

Publikováno v: Vascular Biology, Vol 5, Iss 1, Pp 1-13 (2023)

Intercellular adhesion molecules (ICAMs) are cell surface proteins that play a crucial role in the body’s immune response and inflammatory processes. ICAM1 and ICAM2 are two ICAM family members expressed on the surface of various cell types, includ

Externí odkaz: https://doaj.org/article/4f15ddf2758745e1b658499b089f0162

Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1

Autor: Max L B Grönloh, Janine J G Arts, Sebastián Palacios Martínez, Amerens A van der Veen, Lanette Kempers, Abraham C I van Steen, Joris J T H Roelofs, Martijn A Nolte, Joachim Goedhart, Jaap D van Buul

Publikováno v: Grönloh, M L B, Arts, J J G, Palacios Martínez, S, van der Veen, A A, Kempers, L, van Steen, A C I, Roelofs, J J T H, Nolte, M A, Goedhart, J & van Buul, J D 2023, ' Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1 ', EMBO Reports, vol. 24, no. 1, e55483 . https://doi.org/10.15252/embr.202255483
EMBO reports, 24(1):e55483. Wiley-Blackwell
EMBO Reports, 24(1):e55483. Wiley-Blackwell

Upon inflammation, leukocytes leave the circulation by crossing the endothelial monolayer at specific transmigration ‘hotspot’ regions. Although these regions support leukocyte transmigration, their functionality is not clear. We found that endot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e948a7eee2654f8daa2c0cb6818aa
https://research.vumc.nl/en/publications/977802a3-56bf-40d5-8031-092edf437de6

Heterogeneity and dynamics of ERK and Akt activation by G protein-coupled receptors depend on the activated heterotrimeric G proteins

Autor: Theodorus W. J. Gadella, Max L. B. Grönloh, Sergei Chavez-Abiega, Joachim Goedhart, Frank J. Bruggeman

Kinases are fundamental regulators of cellular functions and play key roles in GPCR-mediated signaling pathways. Kinase activities are generally inferred from cell lysates, hiding the heterogeneity of the individual cellular responses to extracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a86b0a0aceacb13329efbeebd7afb8
https://doi.org/10.1101/2021.07.27.453948

Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

Autor: Satya Khuon, Teng-Leong Chew, Abraham C.I. van Steen, Simon Tol, Mark R. Winter, Lilian Schimmel, Ivar Noordstra, Jos van Rijssel, Marten Postma, Joachim Goedhart, Martijn A. Nolte, Eloi Montanez, John M. Heddleston, Eric Wait, Max L. B. Grönloh, Eike K. Mahlandt, Jaap D. van Buul, Janine J. G. Arts

Upon inflammation, leukocytes rapidly transmigrate across the endothelium to enter the inflamed tissue. Evidence accumulates that leukocytes use preferred exit sites, though it is not yet clear how these hotspots in the endothelium are defined and ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6996148450d29938e07e02c262c8b75
https://doi.org/10.1101/2021.01.18.427135

Endothelial Focal Adhesions Are Functional Obstacles for Leukocytes During Basolateral Crawling.

Autor: Arts, Janine J. G., Mahlandt, Eike K., Schimmel, Lilian, Grönloh, Max L. B., van der Niet, Sanne, Klein, Bart J. A. M., Fernandez-Borja, Mar, van Geemen, Daphne, Huveneers, Stephan, van Rijssel, Jos, Goedhart, Joachim, van Buul, Jaap D.

Publikováno v: Frontiers in Immunology; 5/18/2021, Vol. 12, pN.PAG-N.PAG, 14p