Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Max Kraemer"'
Autor:
Max Kraemer, Thomas Zander, Hakan Alakus, Reinhard Buettner, Su Ir Lyu, Adrian Georg Simon, Wolfgang Schroeder, Christiane J. Bruns, Alexander Quaas
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Esophageal adenocarcinoma (EAC) is one of the deadliest tumor entities worldwide, with a 5-year survival rate of less than 25%. Unlike other tumor entities, personalized therapy options are rare, partly due to the lack of knowledge about spe
Externí odkaz:
https://doaj.org/article/6f9d015d86f4458eac9f7d84c6b7db73
Autor:
Tillmann Bedau, Carina Heydt, Udo Siebolts, Thomas Zander, Max Kraemer, Heike Loeser, Reinhard Buettner, Alexander Quaas
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-6 (2024)
Abstract Background Colorectal cancer (CRC) frequently involves mutations in the KRAS gene, impacting therapeutic strategies and prognosis. The occurrence of KRAS mutations typically precludes the presence of RET fusions, with current medical literat
Externí odkaz:
https://doaj.org/article/4bcf6640f59f4e9faa747df7e057aa0e
Autor:
Ahlem Essakly, Heike Loeser, Max Kraemer, Hakan Alakus, Seung-Hun Chon, Thomas Zander, Reinhard Buettner, Axel M. Hillmer, Christiane J. Bruns, Wolfgang Schroeder, Florian Gebauer, Alexander Quaas
Publikováno v:
Translational Oncology, Vol 13, Iss 2, Pp 157-164 (2020)
Gene amplifications of PIK3CA or KRAS induce a downstream activation of the AKT-mTOR or RAF-ERK-pathways. Interactions of the active AKT pathway have been implicated in the inflammatory tumor microenvironment. Nothing is known about these interaction
Externí odkaz:
https://doaj.org/article/db623cc2141149aa879ebba56e8f3297
Autor:
Heike Loeser, Max Kraemer, Florian Gebauer, Christiane Bruns, Wolfgang Schröder, Thomas Zander, Hakan Alakus, Arnulf Hoelscher, Reinhard Buettner, Philipp Lohneis, Alexander Quaas
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
Background. Indoleamine 2,3-dioxygenase (IDO) is an interferon-inducible immune checkpoint expressed on tumor-infiltrating lymphocytes (TILs). IDO is known as a poor prognostic marker in esophageal squamous cell cancer, while a positive effect was sh
Externí odkaz:
https://doaj.org/article/74f7437396834a7eb8ff896b8ab2fd6e
Autor:
Heike Loeser, Max Kraemer, Florian Gebauer, Christiane Bruns, Wolfgang Schröder, Thomas Zander, Oana-Diana Persa, Hakan Alakus, Arnulf Hoelscher, Reinhard Buettner, Philipp Lohneis, Alexander Quaas
Publikováno v:
OncoImmunology, Vol 8, Iss 5 (2019)
Immune checkpoint modulation in cancer has been demonstrated as a high-value therapeutic strategy in many tumor entities. VISTA is an immune checkpoint receptor regulating T-cell function. To the best of our knowledge, nothing is known about the expr
Externí odkaz:
https://doaj.org/article/1e0aa5632d364863b47659e215408f88
Autor:
Florian Gebauer, Reinhard Buettner, Thomas Zander, Max Kraemer, Sabine Merkelbach-Bruse, Christiane Bruns, Svenja Wagener-Ryczek, Hakan Alakus, Alexander Quaas, Max Schoemmel, Heike Loeser, Martin Thelen, Hans A. Schlößer, Wolfgang Schroeder
Publikováno v:
Cancer Immunology, Immunotherapy
The outcome in esophageal adenocarcinoma (EAC) is still poor with only 20% of patients in Western populations surviving for more than 5 years. Almost nothing is known about the precise composition of immune cells and their gene expression profiles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e87eabc6ca0158c335c2c62c72cacf
https://doi.org/10.1007/s00262-019-02475-w
https://doi.org/10.1007/s00262-019-02475-w
Autor:
Alexander Quaas, Hakan Alakus, Max Kraemer, Arnulf H. Hoelscher, Christiane Bruns, Wolfgang Schröder, Heike Loeser, Reinhard Buettner, Thomas Zander, Philipp Lohneis, Florian Gebauer
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
Journal of Immunology Research
Journal of Immunology Research
Background. Indoleamine 2,3-dioxygenase (IDO) is an interferon-inducible immune checkpoint expressed on tumor-infiltrating lymphocytes (TILs). IDO is known as a poor prognostic marker in esophageal squamous cell cancer, while a positive effect was sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c420eec08c1b08aba59792fc7ff84f75
https://doaj.org/article/74f7437396834a7eb8ff896b8ab2fd6e
https://doaj.org/article/74f7437396834a7eb8ff896b8ab2fd6e
Autor:
Wolfgang Schroeder, Max Kraemer, Alexander Quaas, Ahlem Essakly, Christiane Bruns, Thomas Zander, Axel M. Hillmer, Heike Loeser, Seung-Hun Chon, Florian Gebauer, Reinhard Buettner, Hakan Alakus
Publikováno v:
Translational Oncology
Translational Oncology, Vol 13, Iss 2, Pp 157-164 (2020)
Translational Oncology, Vol 13, Iss 2, Pp 157-164 (2020)
Gene amplifications of PIK3CA or KRAS induce a downstream activation of the AKT-mTOR or RAF-ERK-pathways. Interactions of the active AKT pathway have been implicated in the inflammatory tumor microenvironment. Nothing is known about these interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea8641796ca3e10956adf0dc78c377a
https://pubmed.ncbi.nlm.nih.gov/31865178
https://pubmed.ncbi.nlm.nih.gov/31865178
Autor:
Hakan Alakus, Philipp Lohneis, Florian Gebauer, Thomas Zander, Heike Loeser, Max Kraemer, Wolfgang Schröder, Arnulf H. Hoelscher, Oana-Diana Persa, Christiane J. Bruns, Alexander Quaas, Reinhard Buettner
Publikováno v:
OncoImmunology, Vol 8, Iss 5 (2019)
Oncoimmunology
Oncoimmunology
Immune checkpoint modulation in cancer has been demonstrated as a high-value therapeutic strategy in many tumor entities. VISTA is an immune checkpoint receptor regulating T-cell function. To the best of our knowledge, nothing is known about the expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389a1fafc2bad93f10abe956d4fc0ed6
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50268
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50268
Autor:
Reinhard Buettner, Thomas Zander, Christiane Bruns, Max Kraemer, Patrick Sven Plum, Alexander Quaas, Florian Gebauer, Hakan Alakus, Heike Loeser
Publikováno v:
Diseases of the Esophagus. 31:146-147
Background Targeting Her2 is highly established in cancers of the upper gastrointestinal tract, since clinical studies showed a survival benefit in Her2-positive gastric cancer. To date there is conflicting data concerning the impact of Her2 expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c9be250e39397d5b74bcae452682c51
https://doi.org/10.1093/dote/doy089.ps02.092
https://doi.org/10.1093/dote/doy089.ps02.092