Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Max Koppers"'
Autor:
Nazmiye Özkan, Max Koppers, Inge van Soest, Alexandra van Harten, Daphne Jurriens, Nalan Liv, Judith Klumperman, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear. Here the authors show that endoplasmic reticulum (ER) tubules in the soma of neurons regulate
Externí odkaz:
https://doaj.org/article/cc342bac8e3b45b797d52c6e73112560
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Membrane-bound and membraneless organelles/biomolecular condensates ensure compartmentalization into functionally distinct units enabling proper organization of cellular processes. Membrane-bound organelles form dynamic contacts with each other to en
Externí odkaz:
https://doaj.org/article/cd03447a22f748c19a171187ebd926c8
Autor:
Toshiaki Shigeoka, Max Koppers, Hovy Ho-Wai Wong, Julie Qiaojin Lin, Roberta Cagnetta, Asha Dwivedy, Janaina de Freitas Nascimento, Francesca W. van Tartwijk, Florian Ströhl, Jean-Michel Cioni, Julia Schaeffer, Mark Carrington, Clemens F. Kaminski, Hosung Jung, William A. Harris, Christine E. Holt
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3605-3619.e10 (2019)
Summary: Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report a physical and
Externí odkaz:
https://doaj.org/article/03a40e7b28d94e35809090a5ff021644
Autor:
Max Koppers, Roberta Cagnetta, Toshiaki Shigeoka, Lucia CS Wunderlich, Pedro Vallejo-Ramirez, Julie Qiaojin Lin, Sixian Zhao, Maximilian AH Jakobs, Asha Dwivedy, Michael S Minett, Anaïs Bellon, Clemens F Kaminski, William A Harris, John G Flanagan, Christine E Holt
Publikováno v:
eLife, Vol 8 (2019)
Extrinsic cues trigger the local translation of specific mRNAs in growing axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly t
Externí odkaz:
https://doaj.org/article/9b3b40d5ede643c89c36904b516f8db7
Autor:
Max Koppers, Nazmiye Özkan, Ha H. Nguyen, Daphne Jurriens, Janine McCaughey, Riccardo Stucchi, Maarten Altelaar, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farias
SUMMARYLocal mRNA translation in axons is critical for the spatial and temporal regulation of the axonal proteome. A wide variety of mRNAs are localized and translated in axons, however how protein synthesis is regulated at specific subcellular sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efdb18d33ec2be660c26a10c4c8e118a
https://doi.org/10.1101/2022.11.30.518484
https://doi.org/10.1101/2022.11.30.518484
Autor:
Max Koppers, Christine E. Holt
Publikováno v:
Annual review of neuroscience. 45
Axons receive extracellular signals that help to guide growth and synapse formation during development and to maintain neuronal function and survival during maturity. These signals relay information via cell surface receptors that can initiate local
Autor:
Lucia C. Wunderlich, Francesca van Tartwijk, Julie Q. Lin, Max Koppers, Max Barysevich, Stanislaw Makarchuk, Maximilian A. Jakobs, Christine E. Holt, Clemens F. Kaminski
Publikováno v:
Biophysical Journal. 121:154a
Autor:
Judith Klumperman, Ginny G. Farías, Max Koppers, Inge van Soest, Nalan Liv, Nazmiye Özkan, Alexandra van Harten, Casper C. Hoogenraad
Neuronal function relies on careful coordination of organelle organization and transport. Kinesin-1 mediates transport of the ER and lysosomes into the axon and it is increasingly recognized that contacts between the ER and lysosomes influence organe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d0ccd8fe9df931b293103662eb8cdad
https://doi.org/10.1101/2020.06.16.153734
https://doi.org/10.1101/2020.06.16.153734
Publikováno v:
Current Opinion in Neurobiology. 51:86-94
The tips of axons are often far away from the cell soma where most proteins are synthesized. Recent work has revealed that axonal mRNA transport and localised translation are key regulatory mechanisms that allow these distant outposts of the cell to
Autor:
John G. Flanagan, Toshiaki Shigeoka, Lucia C. S. Wunderlich, Max Koppers, William A. Harris, Christine E. Holt, Maximilian Ah Jakobs, Clemens F. Kaminski, Julie Qiaojin Lin, Asha Dwivedy, Michael S Minett, Anaïs Bellon, Sixian Zhao, Pedro Vallejo-Ramirez, Roberta Cagnetta
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Extrinsic cues trigger the local translation of specific mRNAs in growing axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly t