Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Max Kam‐Kwan Chan"'
Autor:
Philip Chiu‐Tsun Tang, Max Kam‐Kwan Chan, Jeff Yat‐Fai Chung, Alex Siu‐Wing Chan, Dongmei Zhang, Chunjie Li, Kam‐Tong Leung, Calvin Sze‐Hang Ng, Yi Wu, Ka‐Fai To, Hui‐Yao Lan, Patrick Ming‐Kuen Tang
Publikováno v:
Advanced Science, Vol 11, Iss 1, Pp n/a-n/a (2024)
Abstract Macrophage‐myofibroblast transition (MMT) is a newly discovered pathway for mass production of pro‐tumoral cancer‐associated fibroblasts (CAFs) in non‐small cell lung carcinoma (NSCLC) in a TGF‐β1/Smad3 dependent manner. Better un
Externí odkaz:
https://doaj.org/article/87ee915054aa49ad8d44d285ae662e18
Autor:
Max Kam-Kwan Chan, Emily Lok-Yiu Chan, Zoey Zeyuan Ji, Alex Siu-Wing Chan, Chunjie Li, Kam-Tong Leung, Ka-Fai To, Patrick Ming-Kuen Tang
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 2, Pp 316-343 (2023)
Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, b
Externí odkaz:
https://doaj.org/article/f66b695eb39a44d683eec8cd54acc160
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Autor:
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinom
Externí odkaz:
https://doaj.org/article/ba3ca05e7ec94b9aa2d7bbddfdfd4bef
Autor:
Zoey Zeyuan Ji, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Kam-Tong Leung, Xiaohua Jiang, Ka-Fai To, Yi Wu, Patrick Ming-Kuen Tang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and anti-cancer activities are reported, including not only angiogenesis, extra
Externí odkaz:
https://doaj.org/article/a52ec436a9d74b35b7278bb97071615b
Autor:
Philip Chiu-Tsun Tang, Ying-Ying Zhang, Jane Siu-Fan Li, Max Kam-Kwan Chan, Jiaoyi Chen, Ying Tang, Yiming Zhou, Dongmei Zhang, Kam-Tong Leung, Ka-Fai To, Sydney Chi-Wai Tang, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Non-Coding RNA, Vol 8, Iss 3, p 36 (2022)
Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibr
Externí odkaz:
https://doaj.org/article/54e6ce1d99cf439fa1f40b6f1d388ae0
Autor:
Jeff Yat-Fai Chung, Max Kam-Kwan Chan, Jane Siu-Fan Li, Alex Siu-Wing Chan, Philip Chiu-Tsun Tang, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7575 (2021)
Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting immunoregulation via controlling the activation, proliferation, and
Externí odkaz:
https://doaj.org/article/5a214bc6c5c24e0e8b28bd92dcd1f763
Autor:
Philip Chiu-Tsun Tang, Ying-Ying Zhang, Max Kam-Kwan Chan, Winson Wing-Yin Lam, Jeff Yat-Fai Chung, Wei Kang, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4018 (2020)
Renal fibrosis is a common fate of chronic kidney diseases. Emerging studies suggest that unsolved inflammation will progressively transit into tissue fibrosis that finally results in an irreversible end-stage renal disease (ESRD). Renal inflammation
Externí odkaz:
https://doaj.org/article/57cfcf4de98e4f38b25558435cf0a9be
Autor:
Philip Chiu-Tsun Tang, Jeff Yat-Fai Chung, Jinyue Liao, Max Kam-Kwan Chan, Alex Siu-Wing Chan, Guangyao Cheng, Chunjie Li, Xiao-Ru Huang, Calvin Sze-Hang Ng, Eric W-F Lam, Dongmei Zhang, Yi-Ping Ho, Ka-Fai To, Kam-Tong Leung, Xiaohua Jiang, Ho Ko, Tin-Lap Lee, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Science Advances. 8
Tumor innervation is a common phenomenon with unknown mechanism. Here, we discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de novo neurogenesis via a subset showing neuronal phenotypes and pain receptor expression asso
Autor:
Jeff Yat-Fai Chung, Patrick Ming-Kuen Tang, Max Kam-Kwan Chan, Li Wang, Xiao-Ru Huang, Ka-Fai To, Ronald CW Ma, Hui-Yao Lan
Publikováno v:
International journal of biological sciences. 18(14)
Diabetic nephropathy (DN) is a major cause of end-stage kidney disease, where TGF-β1/Smad signaling plays an important role in the disease progression. Our previous studies demonstrated a combination of Traditional Chinese Medicine derived Smad7 ago
Autor:
Max Kam-Kwan Chan, Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Johnny Yuk-Yeung Ho, Tony Pak-Tik Lin, Jiaoyi Chen, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Cancer Letters. 550:215925
Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology and pathology, especially in the progression of inflammatory diseases including cancer. Interestingly, TGF-β was first reported as a cancer suppressor, but inc