Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Max K. Leong"'
Autor:
Sih-Pei Chen, Shian-Ren Lin, Ting-Hsu Chen, Hui-Suan Ng, Hip-Seng Yim, Max K. Leong, Ching-Feng Weng
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112333- (2021)
Diabetes mellitus (DM) is concomitant with significant morbidity and mortality and its prevalence is accumulative in worldwide. The conventional antidiabetic agents are known to mitigate the symptoms of diabetes; however, they may also cause side and
Externí odkaz:
https://doaj.org/article/4e4f22de34fa41f6b02b82a8d0a0d198
Autor:
Max K. Leong, Giang Huong Ta
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 132 (2022)
Skin is the largest organ in the human body, and it works as the natural barrier against the external environment. Furthermore, topical and transdermal drug delivery has emerged as a new effective and safer administration choice. A variety of in vitr
Externí odkaz:
https://doaj.org/article/7a890fc256f4487ca3dd5fe370b4b88b
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Skin direct contact with chemical or physical substances is predisposed to allergic contact dermatitis (ACD), producing various allergic reactions, namely rash, blister, or itchy, in the contacted skin area. ACD can be triggered by various extremely
Externí odkaz:
https://doaj.org/article/61afdaa3bfad421ab9b42d850bde7de7
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 961 (2022)
Topical and transdermal drug delivery is an effective, safe, and preferred route of drug administration. As such, skin permeability is one of the critical parameters that should be taken into consideration in the process of drug discovery and develop
Externí odkaz:
https://doaj.org/article/2344f99db8734fcda553be0309163172
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1877 (2021)
Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors, and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α-amylase enzymes inhibitors can suppress peaks of postprandial glu
Externí odkaz:
https://doaj.org/article/8be80a14fd284547802b22af5a7aec70
Autor:
Shian-Ren Lin, Chia-Hsiang Chang, May-Jwan Tsai, Henrich Cheng, Jian-Chyi Chen, Max K. Leong, Ching-Feng Weng
Publikováno v:
Therapeutic Advances in Chronic Disease, Vol 10 (2019)
Dipeptidyl peptidase IV (DPP-4), an incretin glucagon-like peptide-1 (GLP-1) degrading enzyme, contains two forms and it can exert various physiological functions particular in controlling blood glucose through the action of GLP-1. In diabetic use, t
Externí odkaz:
https://doaj.org/article/c0af3a3e37b04e739513de9d7f63efde
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 174 (2021)
Drug absorption is one of the critical factors that should be taken into account in the process of drug discovery and development. The human colon carcinoma cell layer (Caco-2) model has been frequently used as a surrogate to preliminarily investigat
Externí odkaz:
https://doaj.org/article/7d43196f3e1a41eda5d2a2aa60b6baa1
Autor:
Jirawat Riyaphan, Chien-Hung Jhong, Shian-Ren Lin, Chia-Hsiang Chang, May-Jwan Tsai, Der-Nan Lee, Ping-Jyun Sung, Max K. Leong, Ching-Feng Weng
Publikováno v:
Molecules, Vol 23, Iss 9, p 2260 (2018)
The inhibition of α-glucosidase and α-amylase is a clinical strategy for the treatment of type II diabetes, and herbal medicines have been reported to credibly alleviate hyperglycemia. Our previous study has reported some constituents from plant or
Externí odkaz:
https://doaj.org/article/1583fcfceff64cf9a9730180e5bc9d83
Publikováno v:
Molecules, Vol 23, Iss 7, p 1820 (2018)
P-glycoprotein (P-gp), a membrane-bound transporter, can eliminate xenobiotics by transporting them out of the cells or blood–brain barrier (BBB) at the expense of ATP hydrolysis. Thus, P-gp mediated efflux plays a pivotal role in altering the abso
Externí odkaz:
https://doaj.org/article/277589eeb7d04860a765284729e75d9e
Autor:
Max K. Leong, Ping-Jyun Sung, May Jwan Tsai, Ching-Feng Weng, Jian Chyi Chen, Shian-Ren Lin, Henrich Cheng, Chia Hsiang Chang, Che Fang Hsu
Publikováno v:
British Journal of Pharmacology
Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f5acac1e86da5d7858115826e41e36
https://doi.org/10.1111/bph.14816
https://doi.org/10.1111/bph.14816