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Akademický článek

RNA supply drives physiological granule assembly in neurons

Autor: Karl E. Bauer, Niklas Bargenda, Rico Schieweck, Christin Illig, Inmaculada Segura, Max Harner, Michael A. Kiebler

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

RNA granules are important regulators of RNA metabolism. Here the authors report that RNA granules containing RNA helicase DDX6 disassemble during neuronal maturation.

Externí odkaz: https://doaj.org/article/3bf07c30bb38469e82003fc39bf7e4c8

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Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells

Autor: Melanie Kaseder, Nina Schmid, Katja Eubler, Katharina Goetz, Annette Müller-Taubenberger, Gregory A Dissen, Max Harner, Gerhard Wanner, Axel Imhof, Ignasi Forne, Artur Mayerhofer

Publikováno v: Mol Hum Reprod

In the ovary, proliferation and differentiation of granulosa cells (GCs) drive follicular growth. Our immunohistochemical study in a non-human primate, the Rhesus monkey, showed that the mitochondrial activity marker protein cytochrome c oxidase subu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858141d4e3b1763377324283e4bba9ec
https://doi.org/10.1093/molehr/gaac030

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The dsRBP Staufen2 governs RNP assembly of neuronal Argonaute proteins

Autor: Janina Ehses, Melina Schlegel, Luise Schröger, Rico Schieweck, Sophia Derdak, Martin Bilban, Karl Bauer, Max Harner, Michael A Kiebler

Publikováno v: Nucleic acids research. 50(12)

Mature microRNAs are bound by a member of the Argonaute (Ago1-4) protein family, forming the core of the RNA-induced silencing complex (RISC). Association of RISC with target mRNAs results in ribonucleoprotein (RNP) assembly involved in translational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81967b734f0c9ba053336b617d7c9c8f
https://pubmed.ncbi.nlm.nih.gov/35687120

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The MICOS complex, a structural element of mitochondria with versatile functions

Autor: Max Harner, Siavash Khosravi

Publikováno v: Biological Chemistry. 401:765-778

Mitochondria perform a plethora of functions in various cells of different tissues. Their architecture differs remarkably, for instance in neurons versus steroidogenic cells. Furthermore, aberrant mitochondrial architecture results in mitochondrial d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ceb72a231052a4b4ede387e2adc597
https://doi.org/10.1515/hsz-2020-0103

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Pumilio2 Promotes Growth of Mature Neurons

Autor: Michael A. Kiebler, Bastian Popper, Barbara Saccà, Max Harner, Elisa-Charlott Schöneweiss, Rico Schieweck, Daniela Rieger, Christin Illig

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8998, p 8998 (2021)

RNA-binding proteins (RBPs) are essential regulators controlling both the cellular transcriptome and translatome. These processes enable cellular plasticity, an important prerequisite for growth. Cellular growth is a complex, tightly controlled proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c379e74e9b59715c851a7b6f0f5308c
http://europepmc.org/articles/PMC8396670

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RNA supply drives physiological granule assembly in neurons

Autor: Karl E. Bauer, Niklas Bargenda, Rico Schieweck, Christin Illig, Inmaculada Segura, Max Harner, Michael A. Kiebler

Publikováno v: Nature communications. 13(1)

Membraneless cytoplasmic condensates of mRNAs and proteins, known as RNA granules, play pivotal roles in the regulation of mRNA fate. Their maintenance fine-tunes time and location of protein expression, affecting many cellular processes, which requi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b24ea94393e1a3c0a84cc65224950a
https://pubmed.ncbi.nlm.nih.gov/35589693

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RGS4 RNA secondary structure mediates staufen2 RNP assembly in neurons

Autor: Rico Schieweck, Sandra M. Fernández-Moya, Flora C.Y. Lee, Janina Ehses, Max Harner, Karl E. Bauer, Nicholas M. Luscombe, Michael A. Kiebler, Christin Illig, Jernej Ule, Anob M. Chakrabarti

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 13021, p 13021 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13021

RNA-binding proteins (RBPs) act as posttranscriptional regulators controlling the fate of target mRNAs. Unraveling how RNAs are recognized by RBPs and in turn are assembled into neuronal RNA granules is therefore key to understanding the underlying m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48d255a70c390df4dd9bc4588aa90ba

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Pumilio2 and Staufen2 selectively balance the synaptic proteome

Autor: Antonia Demleitner, Martin Bilban, Max Harner, Sophia Derdak, Michael A. Kiebler, Foong yee Ang, Bastian Popper, Bernd Sutor, Axel Imhof, Saskia Hutten, Ignasi Forné, Rico Schieweck, Daniela Rieger, Therese Riedemann, Karl E. Bauer

Publikováno v: Cell Reports. 35:109279

Neurons have the capacity to adapt to environmental stimuli, a phenomenon termed cellular plasticity. The underlying processes are controlled by a network of RNA-binding proteins (RBPs). Their precise impact, however, is largely unknown. To address t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f277cdf3326e73785222bada6d3a573
https://doi.org/10.1016/j.celrep.2021.109279

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Analysis of Yeast Mitochondria by Electron Microscopy

Autor: Ann-Katrin, Unger, Stefan, Geimer, Max, Harner, Walter, Neupert, Benedikt, Westermann

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1567

Budding yeast Saccharomyces cerevisiae represents a widely used model organism for the study of mitochondrial biogenesis and architecture. Electron microscopy is an essential tool in the analysis of cellular ultrastructure and the precise localizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdbb29c9f83b03637d0660067e43345a
https://pubmed.ncbi.nlm.nih.gov/28276026

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Isolation of Contact Sites Between Inner and Outer Mitochondrial Membranes

Autor: Max, Harner

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1567

Mitochondria are essential organelles of all eukaryotic cells. They perform a plethora of important metabolic functions and have a highly complex architecture that differs drastically between different cells and tissues. Mitochondria are delimited fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b1e5594623070741bc21576ef1eaca3
https://pubmed.ncbi.nlm.nih.gov/28276012

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