Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Max Goebel"'
1
Akademický článek
Western diet triggers cardiac dysfunction in heterozygous Mybpc3-targeted knock-in mice: A two-hit model of hypertrophic cardiomyopathy
Autor: Edgar E. Nollet, Sila Algül, Max Goebel, Saskia Schlossarek, Nicole N. van der Wel, Judith J.M. Jans, Mark A. van de Wiel, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Richard de Goeij-de Haas, Jill Hermans, Jan Bert van Klinken, Michel van Weeghel, Riekelt H. Houtkooper, Lucie Carrier, Connie R. Jimenez, Diederik W.D. Kuster, Jolanda van der Velden
Publikováno v: Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100050- (2023)
Background and aim: Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet (WD) feeding is sufficient to trigger cardiac hypertrophy and dysfunct
Externí odkaz: https://doaj.org/article/a35423357cb242d7a31ba3d7bed60292
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2
Akademický článek
Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
Autor: Rio P. Juni, PhD, Diederik W.D. Kuster, PhD, Max Goebel, MSc, Michiel Helmes, PhD, René J.P. Musters, PhD, Jolanda van der Velden, PhD, Pieter Koolwijk, PhD, Walter J. Paulus, MD, PhD, Victor W.M. van Hinsbergh, PhD
Publikováno v: JACC: Basic to Translational Science, Vol 4, Iss 5, Pp 575-591 (2019)
Summary: The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients with type 2 diabetes mellitus suggest a direct effect of empaglifloz
Externí odkaz: https://doaj.org/article/3ed290af219b4583a9eb3ca67de459dc
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3
Akademický článek
Large-Scale Contractility Measurements Reveal Large Atrioventricular and Subtle Interventricular Differences in Cultured Unloaded Rat Cardiomyocytes
Autor: Edgar E. Nollet, Emmy M. Manders, Max Goebel, Valentijn Jansen, Cord Brockmann, Jorrit Osinga, Jolanda van der Velden, Michiel Helmes, Diederik W. D. Kuster
Publikováno v: Frontiers in Physiology, Vol 11 (2020)
The chambers of the heart fulfill different hemodynamic functions, which are reflected in their structural and contractile properties. While the atria are highly elastic to allow filling from the venous system, the ventricles need to be able to produ
Externí odkaz: https://doaj.org/article/828eff94062f4859ba1a8aa52304554c
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5
Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin
Autor: Michiel Helmes, Walter Paulus, Diederik W. D. Kuster, René J. P. Musters, Victor W.M. van Hinsbergh, Pieter Koolwijk, Rio P. Juni, Jolanda van der Velden, Max Goebel
Publikováno v: Juni, R P, Kuster, D W D, Goebel, M, Helmes, M, Musters, R J P, van der Velden, J, Koolwijk, P, Paulus, W J & van Hinsbergh, V W M 2019, ' Cardiac Microvascular Endothelial Enhancement of Cardiomyocyte Function Is Impaired by Inflammation and Restored by Empagliflozin ', JACC: Basic to Translational Science, vol. 4, no. 5, pp. 575-591 . https://doi.org/10.1016/j.jacbts.2019.04.003
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 5, Pp 575-591 (2019)
JACC: Basic to Translational Science, 4(5), 575-591. Elsevier Inc.
Visual Abstract
Highlights • CMECs exert a direct positive effect on cardiomyocyte contraction and relaxation, which is mainly mediated by endothelial-derived NO. • Pro-inflammatory stimulation of CMECs by pre-incubation with TNF-α or inter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab528a167ca17203cf1e82065e3af5b
https://doi.org/10.1016/j.jacbts.2019.04.003
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6
In vitro model to study the effects of matrix stiffening on Ca2+ handling and myofilament function in isolated adult rat cardiomyocytes
Autor: Elza D. van Deel, Kim Kardux, Inês Falcão-Pires, Dulce Fontoura, Max Goebel, Jolanda van der Velden, Aref Najafi, Erik T. Valent
Publikováno v: The Journal of Physiology. 595:4597-4610
Key points This paper describes a novel model that allows exploration of matrix-induced cardiomyocyte adaptations independent of the passive effect of matrix rigidity on cardiomyocyte function. Detachment of adult cardiomyocytes from the matrix enabl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13ebc1b2eff2950ba2a4a90dcaacb6c2
https://doi.org/10.1113/jp274460
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8
Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice
Autor: Aref Najafi, Lucie Carrier, Ahmet Güçlü, Diederik W. D. Kuster, Elza D. van Deel, Jolanda van der Velden, Max Goebel, Saskia Schlossarek, Nikki van den Heuvel
Publikováno v: Pflugers Archiv-European Journal of Physiology, 467(6), 1303-1317. Springer-Verlag
Pflügers Archiv European Journal of Physiology, 467(6), 1303-1317. Springer Verlag
Najafi, A, Schlossarek, S, van Deel, E D, van den Heuvel, N, Guclu, A, Goebel, M, Kuster, D W D, Carrier, L & van der Velden, J 2015, ' Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice ', Pflügers Archiv European Journal of Physiology, vol. 467, no. 6, pp. 1303-1317 . https://doi.org/10.1007/s00424-014-1570-7
Hypertrophic cardiomyopathy (HCM), the most common genetic cardiac disorder, is frequently caused by mutations in MYBPC3, encoding cardiac myosin-binding protein C (cMyBP-C). Moreover, HCM is the leading cause of sudden cardiac death (SCD) in young a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::debe3fc09033d2b993e2247d6c5530ab
https://doi.org/10.1007/s00424-014-1570-7
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10
Selective phosphorylation of PKA targets after beta-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model
Autor: Vasco Sequeira, Aref Najafi, Lucie Carrier, Jolanda van der Velden, Ilse A. E. Bollen, Max Goebel, Michiel Helmes, Jessica A. Regan, Diederik W.D. Kuster
Publikováno v: Cardiovascular Research, 110(2), 200-214. Oxford University Press
Najafi, A, Sequeira Oliveira, V, Helmes, M, Bollen, I A E, Goebel, M, Regan, J A, Carrier, L, Kuster, D W D & Van der Velden, J 2016, ' Selective phosphorylation of PKA targets after beta-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model ', Cardiovascular Research, vol. 110, no. 2, pp. 200-214 . https://doi.org/10.1093/cvr/cvw026
Aims Hypertrophic cardiomyopathy (HCM) has been associated with reduced β-adrenergic receptor (β-AR) signalling, leading downstream to a low protein kinase A (PKA)-mediated phosphorylation. It remained undefined whether all PKA targets will be affe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e323bd4ef1a8dbfe4e8cc715edf741
https://research.vumc.nl/en/publications/9f7b2285-b3ca-4a20-b198-0d496177adb3
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