Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Max Gerecke"'
Publikováno v:
HETEROCYCLES. 39:693
Publikováno v:
Helvetica Chimica Acta. 58:185-189
The oxidation product obtained by treatment of bulbocapnine methyl ether (2a) with iodine in ethanol/water is not the tetradehydroaporphinium salt 4 as assigned by Gadamer & Kuntze, but a dimer of structure 3. Reduction of 3 with zinc in dilute sulfu
Publikováno v:
Helvetica Chimica Acta. 59:2551-2557
Bulbocapnine methyl ether (2), on treatment with boron halides, affords the aporphine-1,2-diol (3), the novel aporphines 5 and 6 or the phenanthrene derivative 11 depending on the reaction conditions. 3 can be further transformed into corydine methyl
Autor:
Max Gerecke, Arnold Brossi
Publikováno v:
Helvetica Chimica Acta. 62:1549-1558
rac-1,2,10-Trimethoxy-aporphine (14) and rac-2-ethoxy-10,11-dimethoxyaporphine (27) have been synthesized from the 3-phenylphenethylamines 9 and 22 by a new route. The 8-phenyl-3,4-dihydroisoquinolines 11 and 24, the oxo-aporphines 12 and 25 and the
Autor:
Arnold Brossi, Max Gerecke
Publikováno v:
Helvetica Chimica Acta. 47:1117-1123
Trisdehydro-emetinium salts of type IVa were prepared from rac. 2-Dehydroisoemetine (IIa) by oxidation with mercury(II)-acetate. IVa was reduced with sodium borohydride to a mixture of rac. 2-dehydro-emetine (IIIa) and IIa. The same sequence of react
Publikováno v:
Helvetica Chimica Acta. 43:1444-1447
A total synthesis of the antibiotic griseofulvin is described. Starting from phloroglucinol, rac. epi-griseofulvin could be synthesized. The latter was isomerized to rac. griseofulvin and hydrolysed to rac. griseofulvic acid by way of rac. iso-grisro
Publikováno v:
Helvetica Chimica Acta. 53:991-999
A modification of the biotin synthesis of Goldberg & Sternbach is described, enantiomers being separated in the first steps and wrong isomers recyclised. The conversion of the lactone 15 to the thiolactone 16 is done by a new method using potassium t
Publikováno v:
Helvetica Chimica Acta. 43:2071-2082
The total synthesis of griseofulvin, recently announced in a preliminary communication, is described in detail.
Publikováno v:
Helvetica Chimica Acta. 45:2241-2256
Nous decrivons la synthese de quelques derives de la dechlorogriseofulvine et de la dechloro-demethyl-griseofulvine substitues dans le noyau A. Les spectres de resonance magnetique nucleaire se sont reveles tres utiles par la determination des struct
Publikováno v:
Helvetica Chimica Acta. 44:955-960
The preparation of meso- and rac.-2,3-dimercaptosuccinic acid (III a resp. III b) is described. Their configuration has been established by chemical methods and by isolating both optically active isomers of III b.