Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Max G. Parkki"'
Publikováno v:
Toxicology and Applied Pharmacology. 47:55-60
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (20 μg/kg) was administered to homozygous Gunn and Wistar as well as heterozygous rats, and the activity of UDP-glucuronosyltransferase determined in the liver and kidney toward o-aminophenol, p-nitrophenol
Autor:
C. Harvengt, F. Rengo, Patricia A. Glenwright, Luigi Saccà, Margherita Gaiardi, Mario Condorelli, Hahn Ef, Itiro Shirakawa, Reinaldo N. Takahashi, F.F. Foldes, Richard E. Musty, J.P. Desager, J. Fishman, Hani Vainio, A. Kolodej, G. Perez, Massimo Chiariello, I G Karniol, M. Babbini, B.I. Norton, G. Zetler, Maria Bartoletti, Elias Knobel, Bruno Trimarco, Jukka Marniemi, Elliot S. Vesell, A. Rona, Max G. Parkki, K. Kowalewski, Thomas Passananti, M. Vanderbist, L. De Caprio
Publikováno v:
Pharmacology. 13:I-VI
Publikováno v:
Toxicology and Applied Pharmacology. 38:59-70
The effects of the administration of styrene and its metabolites, styrene oxide and styrene glycol, on drug metabolizing enzymes of rat liver were studied. Styrene (three or six daily doses of 500 g/kg) doubled the activities of microsomal p -nitroan
Autor:
Max G Parkki
Publikováno v:
Scandinavian Journal of Work, Environment & Health. 4:53-59
The role of glutathione in the toxicity of styrene has been proposed based on the observations that glutathione inhibits the covalent binding of styrene and styrene oxide in vitro and that the administration of these compounds to animals decreases th
Publikováno v:
Toxicology. 13:233-236
Summary A dose of 20 μg/kg of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) was given to adult male rats intragastrically and the metabolism of [4- 14 C]-testosterone by liver homogenate was examined 1 week later. The overall catabolism of testostero
Publikováno v:
Pharmacology. 13:492-501
Glucuronyl, glucosyl, glutathione, glycine conjugations and epoxide hydration were studied in livers of Wistar and Gunn rats. The activities of bilirubin UDP-glucuronosyl transferase and UDP-glucosyl transferase were reduced in microsomes of homozygo
Autor:
Hahn Ef, F. Rengo, Luigi Saccà, Itiro Shirakawa, B.I. Norton, Jukka Marniemi, M. Vanderbist, Margherita Gaiardi, Bruno Trimarco, G. Zetler, C. Harvengt, M. Babbini, L. De Caprio, F.F. Foldes, Reinaldo N. Takahashi, Patricia A. Glenwright, J.P. Desager, Maria Bartoletti, Thomas Passananti, J. Fishman, Hani Vainio, A. Kolodej, K. Kowalewski, Richard E. Musty, I G Karniol, G. Perez, Massimo Chiariello, A. Rona, Elias Knobel, Mario Condorelli, Elliot S. Vesell, Max G. Parkki
Publikováno v:
Pharmacology. 13:566-570
Publikováno v:
Toxicology and Applied Pharmacology. 46:671-683
Intragastric treatment of rats with 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) dramatically increased the metabolism of benzo( a )pyrene in the liver of Wistar and Gunn rats. The formation of both ethyl acetate and water-soluble metabolites increas
Autor:
Jukka Marniemi, Max G. Parkki
Publikováno v:
Biochemical Pharmacology. 24:1569-1572
A rapid and sensitive assay of glutathione S -epoxide transferase was developed using tritium-labeled styrene oxide as the epoxide substrate. The method is based on the separation of unreacted styrene oxide from the glutathione conjugate formed after
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 614:625-628
The kinetics of the inhibition by cadmium of styrene oxide and benzo (a) pyrene-4,5-oxide hydration were studied in a microsomal preparation from rat liver. Cadmium inhibited the hydration of styrene oxide in an apparently noncompetitive manner, wher