Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Max Frimmer"'
Publikováno v:
International Journal of Peptide and Protein Research. 32:183-193
Cyclic hexapeptide analogues representing the modified retro sequence of the amino acid residues 7-11 of natural somatostatin are known to protect liver cells from phalloidin poisoning. To determine the influence of steric, lipophilic, and charge eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39736cae3130ff873fb1b739764a28d6
https://doi.org/10.1111/j.1399-3011.1988.tb00933.x
https://doi.org/10.1111/j.1399-3011.1988.tb00933.x
Publikováno v:
International Journal of Peptide and Protein Research. 29:621-628
Cyclic somatostatin analogues containing the modified retro sequence of the amino acids Phe7 to Phe11 of the natural compound have been found to exhibit high activity for cytoprotection of rat hepatocytes against cell poisons such as phallotoxins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356c9a68e5f3456fc27bcb9674dc1152
https://doi.org/10.1111/j.1399-3011.1987.tb02292.x
https://doi.org/10.1111/j.1399-3011.1987.tb02292.x
Publikováno v:
Journal of Biological Chemistry. 265:3270-3277
The immunosuppressive and nephrotoxic agent cyclosporin binds to a renal polypeptide with an apparent molecular weight of 75,000 which has been identified as a component of the renal Na(+)-D-glucose cotransporter (Neeb, M., Kunz, U., and Koepsell, H.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0bbf083dfa20c6f81f2b1834b61753
https://doi.org/10.1016/s0021-9258(19)39763-7
https://doi.org/10.1016/s0021-9258(19)39763-7
Publikováno v:
Biochimica et biophysica acta. 1061(2)
The uptake of the cyclopeptide c(Phe-Thr-Lys-Trp-Phe-D-Pro) (008), an analog of somatostatin with retro sequence, was studied in isolated hepatocytes. 008 is taken up by hepatocytes in a concentration-, time-, energy- and temperature- dependent manne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bfc6c69df97269798d77e42fd246c9
https://pubmed.ncbi.nlm.nih.gov/1705441
https://pubmed.ncbi.nlm.nih.gov/1705441
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 284:395-398
Suspensions of rat liver cells were treated in vitro with 25 μg phalloidin per ml cell suspension. After an incubation time of 10 min marked deformations of cell surfaces were observed in scanning electron micrographs. The effect is discussed within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267d9a2e51f39a8368909976a5fdd842
https://doi.org/10.1007/bf00504708
https://doi.org/10.1007/bf00504708
Autor:
Max Frimmer
Publikováno v:
Biologie in unserer Zeit. 12:168-172
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7e033fa73e05159ba4754741b92f6b5
https://doi.org/10.1002/biuz.19820120605
https://doi.org/10.1002/biuz.19820120605
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 301:245-251
The development of typical protrusions in isolated hepatocytes after incubation with phalloidin was prevented by phospholipase A (from bee venom). When cells were preincubated with low concentrations of phospholipase A and the enzyme was removed by w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47e7f9dc36a16b5c65a7aca528cf3fd
https://doi.org/10.1007/bf00507044
https://doi.org/10.1007/bf00507044
Autor:
Kornelia Ziegler, Max Frimmer
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 805:174-180
Cyclosporin A at concentrations of more than 10 nM protects isolated hepatocytes against the action of phalloidin. Cyclosporin A at 100 nM inhibits the uptake of demethyl[ 3 H]phalloin by 50%, and at 5 μM also that of [ 14 C]cholate. This inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74a8b21652b3dc3fd866fe167a5d50de
https://doi.org/10.1016/0167-4889(84)90165-4
https://doi.org/10.1016/0167-4889(84)90165-4
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 307:275-281
3H-Demethylphalloin (3H-DMP) a cyclopeptide very similar to phalloidin is taken up by isolated hepatocytes in vitro. Hepatocytes prepared from newborn animals are less sensitive to phalloidin. Their uptake of 3H-DMP is about one tenth of that of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4910a210104daf67464fd64ca7cabe2d
https://doi.org/10.1007/bf00505944
https://doi.org/10.1007/bf00505944
Autor:
Max Frimmer
Publikováno v:
Toxicology Letters. 35:169-182
In contrast to popular opinion phallotoxins do not play a role in poisoning with Amanita phalloides when the fungi are ingested orally. All toxic properties of this mushroom are due to amatoxins which, in contrast to the phallotoxins, are absorbed up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2e0c1aa3ab8d8e45dc9fa81394098a
https://doi.org/10.1016/0378-4274(87)90204-9
https://doi.org/10.1016/0378-4274(87)90204-9