Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Max E. Royer"'
Publikováno v:
Journal of clinical pharmacology. 31(12)
Cefpodoxime proxetil, a third generation, broad-spectrum, oral cephalosporin, was administered in single doses of 100, 200, 400, 600, and 800 mg (dose expressed as cefpodoxime equivalents) and multiple doses of 100, 200, and 400 mg twice daily to hea
Autor:
Howard Ko, Max E. Royer
Publikováno v:
Journal of Pharmaceutical Sciences. 63:1914-1920
The in vitro binding of drugs by colestipol hydrochloride depended not only upon ionic strength, pH, and type of competing ion but also upon whether association could occur with other molecules. Where feasible, the initial input ratio of drug to bind
Publikováno v:
Analytical Letters. 7:243-255
A gas chromatographic-mass spectrometric (GC-MS) method for measuring dopamine levels in brain tissue has been developed. Deuterated dopamine was prepared by exchange of the aromatic hydrogens with deuterium. The method involves adding a known amount
Publikováno v:
Analytical Letters. 10:1019-1040
Two radioimmunoassay (RIA) assay methods (I, II) have been developed for triazolam (T, U-33,030) in serum and plasma. The parameters of equilibration time, serum blank, antibody specificity, extraction efficiency, and drug-binding to glass were studi
Radioimmunoassay for medroxyprogesterone acetate (Provera®) using the 11α-hydroxy succinyl conjugate
Publikováno v:
Steroids. 23:713-730
A radioimmunoassay was developed for medroxyprogesterone acetate (MPA; Provera®) employing rabbit antibodies made against a bovine serum albumin (BSA) conjugate of the hemisuccinate ester of 11α-hydroxy MPA. The 11α-hydroxyl group was introduced i
Autor:
Max E. Royer, Edward R. Garrett
Publikováno v:
Journal of Pharmaceutical Sciences. 51:451-455
Since alkyl substitution on the mono-esterified dicarboxylic acid of 21-steroid hemi-esters decreases the rate of specific hydroxyl ion catalyzed hydrolysis, the kinetics of aqueous hydrolysis of prednisolone and 6α-methylprednisolone hemi-β,β′-
Autor:
Howard Ko, Max E. Royer
Publikováno v:
Analytical Biochemistry. 20:205-214
A simple titrimetric assay, requiring about a third less time than that required for the Dole procedure (2), has been developed for determining submicromolar amounts of nonpolar acids (e.g., long-chain fatty acids) in depot fat and plasma. The method
Publikováno v:
Analytical Biochemistry. 19:556-560
During the synthesis of a series of dinucleoside phosphates, nucleotides, and simple esters of these nucleotides (1), product separations were carried out by ion-exchange chromatography on Dowex 1X2 when 2′ → 5′ and 3′ → 5′ isomers had to
Autor:
Howard Ko, Max E. Royer
Publikováno v:
Analytical Biochemistry. 26:18-33
Two automated fluorometric procedures using the Technicon Auto-Analyzer, one for plasma (Method I) and the second for plasma (or solutions) deproteinized by perchloric acid (Method II), have been developed. In Method I, the amount of glycerol in plas
Autor:
Karen T. Johnston, Max E. Royer, Terry J. Gilbertson, Ronald P. Stryd, John M. McCall, Howard Ko
Publikováno v:
Journal of pharmaceutical sciences. 66(9)
A simple, sensitive, and specific radioimmunoassay for determining minoxidil was developed. Antiserums to two minoxidil haptens were compared for cross-reactivity and assay levels on human serums. One antiserum had little cross-reactivity with minoxi