Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine.

Autor: Manuel van Gijsel-Bonnello, Kévin Baranger, Philippe Benech, Santiago Rivera, Michel Khrestchatisky, Max de Reggi, Bouchra Gharib

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175369 (2017)

Astrocytes play critical roles in central nervous system homeostasis and support of neuronal function. A better knowledge of their response may both help understand the pathophysiology of Alzheimer's disease (AD) and implement new therapeutic strateg

Externí odkaz: https://doaj.org/article/a1366b9dd1474a049497a19d32c84036

Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse Model

Autor: Santiago Rivera, Max de Reggi, Wassila Carpentier, Delphine Stephan, Kévin Baranger, Bouchra Gharib, Manuel van Gijsel-Bonnello, Michel Khrestchatisky, Philippe Benech

Publikováno v: Neurotherapeutics
Neurotherapeutics, 2019, ⟨10.1007/s13311-019-00754-z⟩
Neurotherapeutics, Springer Verlag, 2019, ⟨10.1007/s13311-019-00754-z⟩

The low-molecular weight thiol pantethine, known as a hypolipidemic and hypocholesterolemic agent, is the major precursor of co-enzyme A. We have previously shown that pantethine treatment reduces amyloid-β (Aβ)-induced IL-1β release and alleviate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816d9d8dd461de7cc8a2ae198fc05d4d
https://hal.science/hal-02339537

Pantethine Down-Regulates Leukocyte Recruitment and Inflammatory Parameters in a Mouse Model of Allergic Airway Inflammation

Autor: Mhamad, Abou-Hamdan, Bouchra, Gharib, Marc, Bajenoff, Valérie, Julia, Max, de Reggi

Publikováno v: Medical Science Monitor Basic Research

BACKGROUND Migration of leukocytes into airways is the hallmark of allergic asthma. The aim of this study was to target the pathological process using pantethine, a pleiotropic natural compound which has been recently shown to down-regulate chemokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c56c9da7712043f8b0120f10f92a2467
https://pubmed.ncbi.nlm.nih.gov/29176546

Hyaluronate levels and markers of oxidative stress in the serum of Sudanese subjects at risk of infection with Schistosoma mansoni

Autor: Max De Reggi, Nasr Eldin Elwali, Ould M.S. Abdallahi, Mohamed-Ali Qurashi, Marion Pascal, Bouchra Gharib, Adil Mergani, Mubarak M.A. Magzoub

Publikováno v: Transactions of the Royal Society of Tropical Medicine and Hygiene. 94:66-70

We showed previously that infection by Schistosoma mansoni not only triggers the production of reactive oxygen species in mouse liver but also leads to the alteration of antioxidant defences. To determine whether such events occur in humans, we measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e259e633e3eb7ecb59dd77e5f0bb97f
https://doi.org/10.1016/s0035-9203(00)90443-7

Lithostathine, the Presumed Pancreatic Stone Inhibitor, Does Not Interact Specifically with Calcium Carbonate Crystals

Autor: Max De Reggi, Véronique Stoven, Louis Patard, Bouchra Gharib

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1998, 273 (9), pp.4967-4971. ⟨10.1074/jbc.273.9.4967⟩

Lithostathine (pancreatic stone protein, Reg protein) is, in addition to albumin, the major nonenzymatic protein of the pancreatic juice. It has been assumed to inhibit calcium carbonate precipitation and therefore to prevent stone formation in the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7aa2be45b89df813938ebd3d707dd1
https://doi.org/10.1074/jbc.273.9.4967