Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Max D. Wellenstein"'
Autor:
Olga S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. Isaeva, Hannah Garner, Max D. Wellenstein, Noor Bakker, Danique E.M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A.M. Raeven, Kim Vrijland, Marleen Kok, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the sys
Externí odkaz:
https://doaj.org/article/b656e036ddb5458b8a3bb50ca339a61b
Autor:
Dario Zimmerli, Chiara S. Brambillasca, Francien Talens, Jinhyuk Bhin, Renske Linstra, Lou Romanens, Arkajyoti Bhattacharya, Stacey E. P. Joosten, Ana Moises Da Silva, Nuno Padrao, Max D. Wellenstein, Kelly Kersten, Mart de Boo, Maurits Roorda, Linda Henneman, Roebi de Bruijn, Stefano Annunziato, Eline van der Burg, Anne Paulien Drenth, Catrin Lutz, Theresa Endres, Marieke van de Ven, Martin Eilers, Lodewyk Wessels, Karin E. de Visser, Wilbert Zwart, Rudolf S. N. Fehrmann, Marcel A. T. M. van Vugt, Jos Jonkers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Tripe-negative breast cancers poorly respond to immune checkpoint inhibition therapy, due to their immune-hostile tumour microenvironment. Authors here show that the oncogene MYC plays a pivotal role in suppressing anti-tumour immunity via directly r
Externí odkaz:
https://doaj.org/article/07f7321be51a4bf993332239abb08b2b
Autor:
Kevin Kos, Camilla Salvagno, Max D. Wellenstein, Muhammad A. Aslam, Denize A. Meijer, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A.M. Raeven, Martina Schmittnaegel, Carola H. Ries, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
While regulatory T cells (Tregs) and macrophages have been recognized as key orchestrators of cancer-associated immunosuppression, their cellular crosstalk within tumors has been poorly characterized. Here, using spontaneous models for breast cancer,
Externí odkaz:
https://doaj.org/article/6e040c8634824418819d91cace555fe4
Autor:
Stefan Prekovic, Karianne Schuurman, Isabel Mayayo-Peralta, Anna G. Manjón, Mark Buijs, Selçuk Yavuz, Max D. Wellenstein, Alejandro Barrera, Kim Monkhorst, Anne Huber, Ben Morris, Cor Lieftink, Theofilos Chalkiadakis, Ferhat Alkan, Joana Silva, Balázs Győrffy, Liesbeth Hoekman, Bram van den Broek, Hans Teunissen, Donna O. Debets, Tesa Severson, Jos Jonkers, Timothy Reddy, Karin E. de Visser, William Faller, Roderick Beijersbergen, Maarten Altelaar, Elzo de Wit, Rene Medema, Wilbert Zwart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Glucocorticoids (GC) are reported to block cancer cell proliferation, but the mode of action is unclear. Here the authors show that glucocorticoid receptor activation induces cancer cell dormancy in lung cancer by regulating CDKN1C expression through
Externí odkaz:
https://doaj.org/article/e4c712e9c2534821b3dbea828efb9470
Autor:
Marcin Stawowczyk, Max D. Wellenstein, Sharrell B. Lee, Shira Yomtoubian, Anna Durrans, Hyejin Choi, Navneet Narula, Nasser K. Altorki, Dingcheng Gao, Vivek Mittal
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 2, Pp 55-64 (2017)
Molecularly targeted therapies benefit approximately 15–20% of non-small cell lung cancer (NSCLC) patients carrying specific drug-sensitive mutations. Thus, there is a clinically unmet need for the identification of novel targets for drug developme
Externí odkaz:
https://doaj.org/article/97075bf7c3e04161aaec3dbf287501d4
Autor:
Kelly Kersten, Seth B. Coffelt, Marlous Hoogstraat, Niels J.M. Verstegen, Kim Vrijland, Metamia Ciampricotti, Chris W. Doornebal, Cheei-Sing Hau, Max D. Wellenstein, Camilla Salvagno, Parul Doshi, Esther H. Lips, Lodewyk F.A. Wessels, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 6, Iss 8 (2017)
Patients with primary solid malignancies frequently exhibit signs of systemic inflammation. Notably, elevated levels of neutrophils and their associated soluble mediators are regularly observed in cancer patients, and correlate with reduced survival
Externí odkaz:
https://doaj.org/article/caf49ccdba7f4bf4a3af322e5ee3f07c
Autor:
Jake Yeung, Maria Florescu, Peter Zeller, Buys Anton de Barbanson, Max D. Wellenstein, Alexander van Oudenaarden
Publikováno v:
Nature Biotechnology
Regulation of chromatin states involves the dynamic interplay between different histone modifications to control gene expression. Recent advances have enabled mapping of histone marks in single cells, but most methods are constrained to profile only
Autor:
Kevin Kos, Muhammad A. Aslam, Rieneke van de Ven, Max D. Wellenstein, Wietske Pieters, Antoinette van Weverwijk, Danique E.M. Duits, Kim van Pul, Cheei-Sing Hau, Kim Vrijland, Daphne Kaldenbach, Elisabeth A.M. Raeven, Sergio A. Quezada, Rudi Beyaert, Heinz Jacobs, Tanja D. de Gruijl, Karin E. de Visser
Publikováno v:
CELL REPORTS
Cell Reports, 38(9):110447. Cell Press
Kos, K, Aslam, M A, van de Ven, R, Wellenstein, M D, Pieters, W, van Weverwijk, A, Duits, D E M, van Pul, K, Hau, C-S, Vrijland, K, Kaldenbach, D, Raeven, E A M, Quezada, S A, Beyaert, R, Jacobs, H, de Gruijl, T D & de Visser, K E 2022, ' Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche ', Cell Reports, vol. 38, no. 9, 110447 . https://doi.org/10.1016/j.celrep.2022.110447
Cell Reports, 38(9):110447. Cell Press
Kos, K, Aslam, M A, van de Ven, R, Wellenstein, M D, Pieters, W, van Weverwijk, A, Duits, D E M, van Pul, K, Hau, C-S, Vrijland, K, Kaldenbach, D, Raeven, E A M, Quezada, S A, Beyaert, R, Jacobs, H, de Gruijl, T D & de Visser, K E 2022, ' Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche ', Cell Reports, vol. 38, no. 9, 110447 . https://doi.org/10.1016/j.celrep.2022.110447
Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly understood. Here, we investigate the impact of mammary tumorigenesis on regulatory T cells (
Autor:
Lodewyk F. A. Wessels, Seth B. Coffelt, Karin E. de Visser, Iris de Rink, Linda Henneman, Ingrid van der Heijden, Eva Schut, Kim Vrijland, Cheei-Sing Hau, Renske de Korte-Grimmerink, Danique E.M. Duits, Anne Paulien Drenth, Ton N. Schumacher, Jos Jonkers, Sjors M. Kas, Max D. Wellenstein, Maarten Slagter, Stefan Prekovic, Martine H. van Miltenburg, Wilbert Zwart
Publikováno v:
Nature
Cancer-associated systemic inflammation is strongly linked to poor disease outcome in patients with cancer1,2. For most human epithelial tumour types, high systemic neutrophil-to-lymphocyte ratios are associated with poor overall survival3, and exper
Autor:
Kevin, Kos, Muhammad A, Aslam, Rieneke, van de Ven, Max D, Wellenstein, Wietske, Pieters, Antoinette, van Weverwijk, Danique E M, Duits, Kim, van Pul, Cheei-Sing, Hau, Kim, Vrijland, Daphne, Kaldenbach, Elisabeth A M, Raeven, Sergio A, Quezada, Rudi, Beyaert, Heinz, Jacobs, Tanja D, de Gruijl, Karin E, de Visser
Publikováno v:
Cell reports. 38(9)
Breast cancer is accompanied by systemic immunosuppression, which facilitates metastasis formation, but how this shapes organotropism of metastasis is poorly understood. Here, we investigate the impact of mammary tumorigenesis on regulatory T cells (