Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Max Brenner"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Human milk fat globule epidermal growth factor-factor VIII (MFG-E8) functions as a bridging molecule to promote the removal of dying cells by professional phagocytes. E. coli-expressed histidine-tagged recombinant human MFG-E8 (rhMFG-E8) is
Externí odkaz:
https://doaj.org/article/0a5e77939b8c4804b6cd01f2b9042996
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The heightened risk of ionizing radiation exposure, stemming from radiation accidents and potential acts of terrorism, has spurred growing interests in devising effective countermeasures against radiation injury. High-dose ionizing radiation exposure
Externí odkaz:
https://doaj.org/article/2303c3d29bae4f6b94d9ff513aa56cec
Autor:
Hui Jin, Monowar Aziz, Atsushi Murao, Molly Kobritz, Andrew J. Shih, Robert P. Adelson, Max Brenner, Ping Wang
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Extracellular cold-inducible RNA-binding protein (eCIRP) is a key mediator of severity and mortality in sepsis. We found that stimulation of mouse bone marrow–derived neutrophils (BMDNs) with eCIRP generated a distinct neutrophil subpopulation, cha
Externí odkaz:
https://doaj.org/article/1d20bd816f2a45939583bbeed84b5bba
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionExposure to high-dose ionizing radiation causes tissue injury, infections and even death due to immune dysfunction. The triggering receptor expressed on myeloid cells-1 (TREM-1) has been demonstrated to critically amplify and dysregulate
Externí odkaz:
https://doaj.org/article/84742775f26d4f0b89e9f4366f9c78d5
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Introduction: Acute kidney injury is associated with elevated serum levels of extracellular cold-inducible RNA-binding protein (eCIRP), a damage-associated molecular pattern released during ischemia/reperfusion injury, hemorrhagic shock, and sepsis.
Externí odkaz:
https://doaj.org/article/cb4073837d3240e2ad071de132457efa
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a pattern recognition receptor, which can be upregulated in inflammatory diseases as an amplifier of immune responses. Once activated, TREM-1 induces the production and release of pro-i
Externí odkaz:
https://doaj.org/article/1be9d76bbc08462a935952d715725120
Autor:
Xiaoling Qiang, Jianhua Li, Shu Zhu, Mingzhu He, Weiqiang Chen, Yousef Al-Abed, Max Brenner, Kevin J. Tracey, Ping Wang, Haichao Wang
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
BackgroundHepatic ischemia and reperfusion (I/R) injury is commonly associated with surgical liver resection or transplantation, and represents a major cause of liver damage and graft failure. Currently, there are no effective therapies to prevent he
Externí odkaz:
https://doaj.org/article/76d352771b9b479f8c7f8de6ce95e2fc
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266163 (2022)
Objective and designWe examined the role of eCIRP in the pathogenesis of bleomycin-induced pulmonary fibrosis (PF).Material and methodsPublicly available gene expression omnibus datasets were analyzed for the expression of CIRP in lung samples from p
Externí odkaz:
https://doaj.org/article/a20aac2ee5c34d7399514bc8003ca677
Publikováno v:
Molecular Medicine, Vol 25, Iss 1, Pp 1-12 (2019)
Abstract Background Alcohol intake predisposes to infections and sepsis. Alcohol and sepsis inhibit the expression of milk fat globule epidermal growth factor-factor VIII (MFG-E8), a glycoprotein essential for optimal efferocytosis, resulting in the
Externí odkaz:
https://doaj.org/article/9194c6deca684e01ba3e1f6f635cd6ca
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Stimulator of IFN genes (STING) activates TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) to produce type I IFNs. Extracellular cold-inducible RNA-binding protein (eCIRP) is released from cells during hemorrhagic shock (HS). We hypoth
Externí odkaz:
https://doaj.org/article/2f6409490dd4418cbe9fcf263240583e