Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Max Amoss"'
Publikováno v:
Biochemical and Biophysical Research Communications. 48:1093-1099
The tetrapeptide pGlu-Tyr-Arg-Trp-NH2 was synthesized by solid phase methodology; its characterization by nuclear magnetic resonance and mass spectrometry is demonstrated. Contrary to earlier claims in the literature, pGlu-Tyr-Arg-Trp-NH2 stimulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7961e01236f9b4d856caa4803ed48002
https://doi.org/10.1016/0006-291x(72)90821-2
https://doi.org/10.1016/0006-291x(72)90821-2
Autor:
Frederick Naftolin, Roger Guillemin, Robert W. Rebar, S. S. C. Yen, Kenneth J. Ryan, Y. Ehara, G. VadenBerg, Jean Rivier, Kurt Benirschke, Max Amoss, S. Engblom
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 34:1108-1111
Synthetic LRF (single IV 150 μg dose) elicited a prompt increase in circulating LH in all 7 male subjects tested. The mean maximal rise to greater than 8-fold basal levels was reached within 20–30 min. A concomitant but quantitatively smaller FSH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee0eaf9ecd687aecb819fc1f305dc48
https://doi.org/10.1210/jcem-34-6-1108
https://doi.org/10.1210/jcem-34-6-1108
Publikováno v:
Biochemical and Biophysical Research Communications. 44:205-210
Summary A purification sequence for the ovine hypothalamic LH-releasing factor is reported. From 300,000 sheep brains, ca. 200 μg have been obtained of a material containing ⪯ 56% peptide, of which 94% can be accounted for by the amino acids His 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b4037f4b3ace7eaf4224fb9cadb794a
https://doi.org/10.1016/s0006-291x(71)80179-1
https://doi.org/10.1016/s0006-291x(71)80179-1
Publikováno v:
The Journal of clinical endocrinology and metabolism. 35(1)
The oral administration to rats of synthetic LRF or of the (amidated) N-terminal tripeptide-fragment of LRF is capable of eliciting a statistically significant increase in plasma LH, the highest dose of LRF also elevating plasma FSH. The highest dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be1093449d913c5c457ea6ebc6661a1
https://pubmed.ncbi.nlm.nih.gov/4555782
https://pubmed.ncbi.nlm.nih.gov/4555782
Publikováno v:
Endocrinology. 91(2)
A method for preparing short—term enzymatically dispersed pituitary cell cultures is described. It has been used to assay hypothalamic releasing factors. The cells secrete TSH or LH and FSH in amounts directly related to the dose of TRF or LRF resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59056a8f0b7dfba5f260d7ce3237d49c
https://pubmed.ncbi.nlm.nih.gov/4630101
https://pubmed.ncbi.nlm.nih.gov/4630101
Autor:
Roger Guillemin, Jean Rivier, Nicholas Ling, Geoffrey Grant, M. Monahan, Max Amoss, Roger Burgus, Wylie Vale
Publisher Summary This chapter reviews the status of knowledge regarding the chemical structures of the hypothalamic releasing factors in general and to survey some of the recent studies on structure-function relationships of the two hormones, TRF (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6c330b6cc8462af815b1f1505815b93
https://doi.org/10.1016/s0079-6123(08)64065-0
https://doi.org/10.1016/s0079-6123(08)64065-0
Publikováno v:
The Journal of clinical endocrinology. 34
Results in previous experiments led to the assumption that if electr ical stimulation of the hypothalamus in the rabbit stimulates the release of LH-releasing factor (LRF), which in turn induces the secretion of LH and FSH leading to ovulation in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602bb41cc9724ab52f43d16203e35ec3
https://pubmed.ncbi.nlm.nih.gov/12256596
https://pubmed.ncbi.nlm.nih.gov/12256596
Autor:
Roger Guillemin, Wylie Vale, Roger Burgus, Richard Blackwell, M. Monahan, Geoffrey Grant, Jean Rivier, Max Amoss
Publikováno v:
Science. 176:933-934
Two analogs of the hypothalamic luteinizing hormone releasing factor modified at the histidine-2 position were tested for biological activity (secretion of luteinizing hormone) in cultures of dispersed rat anterior pituitary cells. The analog in whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2cf9278bb519b2ecbf66ee73c93075
https://doi.org/10.1126/science.176.4037.933
https://doi.org/10.1126/science.176.4037.933