Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Max A. Seibold"'
Autor:
Jamie L. Everman, Satria P. Sajuthi, Maude A. Liegeois, Nathan D. Jackson, Erik H. Collet, Michael C. Peters, Maurizio Chioccioli, Camille M. Moore, Bhavika B. Patel, Nathan Dyjack, Roger Powell, Cydney Rios, Michael T. Montgomery, Celeste Eng, Jennifer R. Elhawary, Angel C. Y. Mak, Donglei Hu, Scott Huntsman, Sandra Salazar, Luigi Feriani, Ana Fairbanks-Mahnke, Gianna L. Zinnen, Cole R. Michel, Joe Gomez, Xing Zhang, Vivian Medina, Hong Wei Chu, Pietro Cicuta, Erin D. Gordon, Pamela Zeitlin, Victor E. Ortega, Nichole Reisdorph, Eleanor M. Dunican, Monica Tang, Brett M. Elicker, Travis S. Henry, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Elliot Israel, Bruce D. Levy, David T. Mauger, Deborah A. Meyers, Kaharu Sumino, David S. Gierada, Annette T. Hastie, Wendy C. Moore, Loren C. Denlinger, Nizar N. Jarjour, Mark L. Schiebler, Sally E. Wenzel, Prescott G. Woodruff, Jose Rodriguez-Santana, Chad G. Pearson, Esteban G. Burchard, John V. Fahy, Max A. Seibold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical si
Externí odkaz:
https://doaj.org/article/e5fbd453726447a6a3e42371a05beeb5
Autor:
Nathan D. Jackson, Nathan Dyjack, Elena Goleva, Lianghua Bin, Michael T. Montgomery, Cydney Rios, Jamie L. Everman, Patricia Taylor, Caroline Bronchick, Brittany N. Richers, Donald Y.M. Leung, Max A. Seibold
Publikováno v:
JID Innovations, Vol 4, Iss 4, Pp 100279- (2024)
A subgroup of patients with atopic dermatitis (AD) suffers from recurrent, disseminated herpes simplex virus skin infection, termed eczema herpeticum. To determine the transcriptional mechanisms of the skin and immune system pathobiology that underli
Externí odkaz:
https://doaj.org/article/5ac4c762010240c089e6706b050cde60
Autor:
Matthew T. Walker, Jeffrey C. Bloodworth, Timothy S. Kountz, Samantha L. McCarty, Jeremy E. Green, Ryan P. Ferrie, Jackson A. Campbell, Samantha H. Averill, Kenneth B. Beckman, Leslie C. Grammer, Celeste Eng, Pedro C. Avila, Harold J. Farber, William Rodriguez-Cintron, Jose R. Rodriguez-Santana, Denise Serebrisky, Shannon M. Thyne, Max A. Seibold, Esteban G. Burchard, Rajesh Kumar, Joan M. Cook-Mills
Publikováno v:
Frontiers in Allergy, Vol 5 (2024)
BackgroundPrevious research showed that 5-hydroxytryptophan (5HTP), a metabolic precursor of serotonin, reduces allergic lung inflammation by inhibiting eosinophil migration across endothelial monolayers.ObjectiveIt is unknown if serotonin receptors
Externí odkaz:
https://doaj.org/article/ad1b012df26e431ba67b4e2f8672355d
Autor:
Javier Perez-Garcia, Maria Pino-Yanes, Elizabeth G. Plender, Jamie L. Everman, Celeste Eng, Nathan D. Jackson, Camille M. Moore, Kenneth B. Beckman, Vivian Medina, Sunita Sharma, Daniel Efrain Winnica, Fernando Holguin, José Rodríguez-Santana, Jesús Villar, Elad Ziv, Max A. Seibold, Esteban G. Burchard
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has assessed whether albuter
Externí odkaz:
https://doaj.org/article/dd94221e29c147b18ed997f3b41be0f7
Autor:
Satria P. Sajuthi, Jamie L. Everman, Nathan D. Jackson, Benjamin Saef, Cydney L. Rios, Camille M. Moore, Angel C. Y. Mak, Celeste Eng, Ana Fairbanks–Mahnke, Sandra Salazar, Jennifer Elhawary, Scott Huntsman, Vivian Medina, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Gonçalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Noah A. Zaitlen, Sam Oh, NHLBI Trans–Omics for Precision Medicine (TOPMed) Consortium, José Rodríguez–Santana, Esteban G. Burchard, Max A. Seibold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Externí odkaz:
https://doaj.org/article/2becd8c53e824b738a9f10d4fbec7c85
Autor:
Jaehyun Joo, Angel C. Y. Mak, Shujie Xiao, Patrick M. Sleiman, Donglei Hu, Scott Huntsman, Celeste Eng, Mengyuan Kan, Avantika R. Diwakar, Jessica A. Lasky-Su, Scott T. Weiss, Joanne E. Sordillo, Ann C. Wu, Michelle Cloutier, Glorisa Canino, Erick Forno, Juan C. Celedón, Max A. Seibold, Hakon Hakonarson, L. Keoki Williams, Esteban G. Burchard, Blanca E. Himes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Variability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator r
Externí odkaz:
https://doaj.org/article/808f2b5b81bf46269caaa117e076f965
Autor:
Satria P. Sajuthi, Jamie L. Everman, Nathan D. Jackson, Benjamin Saef, Cydney L. Rios, Camille M. Moore, Angel C. Y. Mak, Celeste Eng, Ana Fairbanks-Mahnke, Sandra Salazar, Jennifer Elhawary, Scott Huntsman, Vivian Medina, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Gonçalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Noah A. Zaitlen, Sam Oh, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, José Rodríguez-Santana, Esteban G. Burchard, Max A. Seibold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Understanding regulation of genes associated to disease can reveal insights into disease mechanisms. Here, the authors perform an airway epithelial transcriptome-wide association analysis to elucidate genetic determinants of airway dysfunction in ast
Externí odkaz:
https://doaj.org/article/f0bfdc317fbf49d288c90aff61c49c7f
Autor:
Maya E. Kotas, Camille M. Moore, Jose G. Gurrola II, Steven D. Pletcher, Andrew N. Goldberg, Raquel Alvarez, Sheyla Yamato, Preston E. Bratcher, Ciaran A. Shaughnessy, Pamela L. Zeitlin, Irene H. Zhang, Yingchun Li, Michael T. Montgomery, Keehoon Lee, Emily K. Cope, Richard M. Locksley, Max A. Seibold, Erin D. Gordon
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common epithelial cell types (mucus secretory an
Externí odkaz:
https://doaj.org/article/6f5341174d7842269c992904cbd03de8
Autor:
Mari Numata, Satria Sajuthi, Yury A. Bochkov, Jessica Loeffler, Jamie Everman, Eszter K. Vladar, Riley A. Cooney, Richard Lee Reinhardt, Andrew H. Liu, Max A. Seibold, Dennis R. Voelker
Publikováno v:
Viruses, Vol 15, Iss 3, p 747 (2023)
Rhinoviruses (RVs) are major instigators of acute exacerbations of asthma, COPD, and other respiratory diseases. RVs are categorized into three species (RV-A, RV-B, and RV-C), which comprise more than 160 serotypes, making it difficult to develop an
Externí odkaz:
https://doaj.org/article/0ee3e5c3b3924c77b05a74178c0a5d80
Autor:
Satria P. Sajuthi, Peter DeFord, Yingchun Li, Nathan D. Jackson, Michael T. Montgomery, Jamie L. Everman, Cydney L. Rios, Elmar Pruesse, James D. Nolin, Elizabeth G. Plender, Michael E. Wechsler, Angel C. Y. Mak, Celeste Eng, Sandra Salazar, Vivian Medina, Eric M. Wohlford, Scott Huntsman, Deborah A. Nickerson, Soren Germer, Michael C. Zody, Gonçalo Abecasis, Hyun Min Kang, Kenneth M. Rice, Rajesh Kumar, Sam Oh, Jose Rodriguez-Santana, Esteban G. Burchard, Max A. Seibold
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
ACE2 and TMPRSS2 have received recent attention as entry factors for SARS-CoV-2. Here the authors analyze nasal airway transcriptome data from 695 children determining ACE2 and TMPRSS2 expression is induced by viral and type2 inflammation, respective
Externí odkaz:
https://doaj.org/article/5998991851af4757adcf82673111f6e4