Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Max, Levy"'
Autor:
Chey Loveday, Kevin Litchfield, Paula Z. Proszek, Alex J. Cornish, Flavia Santo, Max Levy, Geoff Macintyre, Amy Holryod, Peter Broderick, Darshna Dudakia, Barbara Benton, Maise Al Bakir, Crispin Hiley, Emily Grist, Charles Swanton, Robert Huddart, Tom Powles, Simon Chowdhury, Janet Shipley, Simon O’Connor, James D. Brenton, Alison Reid, David Gonzalez de Castro, Richard S. Houlston, Clare Turnbull
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Most testicular germ-cell tumours are exquisitely sensitive to platinum-based chemotherapies, but little is known about why 10% are resistant. Here, the authors explore the potential underlying mechanisms by probing the genomic landscape of platinum-
Externí odkaz:
https://doaj.org/article/fd830b167ba2414b9bc17a0f92cc02a5
Publikováno v:
Journal of Biological Engineering, Vol 13, Iss 1, Pp 1-12 (2019)
Abstract Traditional therapeutics and vaccines represent the bedrock of modern medicine, where isolated biochemical molecules or designed proteins have led to success in treating and preventing diseases. However, several adaptive pathogens, such as m
Externí odkaz:
https://doaj.org/article/14ee35bafcbb4acaa231eea5b1e6e0b1
Autor:
Kristen A. Eller, Dana F. Stamo, Colleen R. McCollum, Jocelyn K. Campos, Max Levy, Prashant Nagpal, Anushree Chatterjee
Publikováno v:
Nanoscale Advances. 5:1910-1918
Superoxide-producing CdTe-2.4 eV nanoparticles treat an intracellular infection of Salmonella in a 2D preosteoblast bone infection model.
Autor:
Kevin Litchfield, Max Levy, Darshna Dudakia, Paula Proszek, Claire Shipley, Sander Basten, Elizabeth Rapley, D. Timothy Bishop, Alison Reid, Robert Huddart, Peter Broderick, David Gonzalez de Castro, Simon O'Connor, Rachel H. Giles, Richard S. Houlston, Clare Turnbull
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
There is some evidence of a hereditary risk for developing testicular germ cell tumours. Here, the authors use whole-exome sequencing and identify a risk variant for the disease in DNAAF1, a gene involved in microtubule-based cilia.
Externí odkaz:
https://doaj.org/article/5514be44ed294c9ca7423b116df904dc
Autor:
Samuel M. Goodman, Max Levy, Fei-Fei Li, Yuchen Ding, Colleen M. Courtney, Partha P. Chowdhury, Annette Erbse, Anushree Chatterjee, Prashant Nagpal
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
The rapid emergence of superbugs, or multi-drug resistant (MDR) organisms, has prompted a search for novel antibiotics, beyond traditional small-molecule therapies. Nanotherapeutics are being investigated as alternatives, and recently superoxide-gene
Externí odkaz:
https://doaj.org/article/db167e27f83e4f1a93d0c04c18f5b7e1
Publikováno v:
ACS Biomaterials Science & Engineering. 7:1863-1875
Drug-resistant bacterial infections are a growing cause of illness and death globally. Current methods of treatment are not only proving less effective but also perpetuate evolution of new resistance. Here we propose, through an in vivo model, a new
Autor:
Alex J. Cornish, Barbara Benton, Chey Loveday, Robert Huddart, James D. Brenton, Paula Proszek, Max Levy, Clare Turnbull, Peter Broderick, Charles Swanton, Richard S. Houlston, Janet Shipley, Maise Al Bakir, Kevin Litchfield, Emily Grist, Simon Chowdhury, Flavia Santo, Amy Holryod, Crispin T. Hiley, Alison Reid, Thomas Powles, Simon O'Connor, Geoff Macintyre, David Gonzalez de Castro, Darshna Dudakia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Loveday, C, Litchfield, K, Proszek, P Z, Cornish, A J, Santo, F, Levy, M, Macintyre, G, Holryod, A, Broderick, P, Dudakia, D, Benton, B, Bakir, M A, Hiley, C, Grist, E, Swanton, C, Huddart, R, Powles, T, Chowdhury, S, Shipley, J, O'Connor, S, Brenton, J D, Reid, A, de Castro, D G, Houlston, R S & Turnbull, C 2020, ' Genomic landscape of platinum resistant and sensitive testicular cancers ', Nature Communications, vol. 11, no. 1, pp. 2189 . https://doi.org/10.1038/s41467-020-15768-x
Nature Communications
Loveday, C, Litchfield, K, Proszek, P Z, Cornish, A J, Santo, F, Levy, M, Macintyre, G, Holryod, A, Broderick, P, Dudakia, D, Benton, B, Bakir, M A, Hiley, C, Grist, E, Swanton, C, Huddart, R, Powles, T, Chowdhury, S, Shipley, J, O'Connor, S, Brenton, J D, Reid, A, de Castro, D G, Houlston, R S & Turnbull, C 2020, ' Genomic landscape of platinum resistant and sensitive testicular cancers ', Nature Communications, vol. 11, no. 1, pp. 2189 . https://doi.org/10.1038/s41467-020-15768-x
Nature Communications
While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and copy number analysis in 40 tu
Autor:
Colleen M. Courtney, Thomas R. Aunins, Samuel M. Goodman, Kristen A. Eller, Anushree Chatterjee, Max Levy, Prashant Nagpal
Publikováno v:
ACS Biomaterials Science & Engineering. 5:4206-4218
Nanomaterials have been extensively used in the biomedical field and have recently garnered attention as potential antimicrobial agents. Cadmium telluride quantum dots (QDs) with a bandgap of 2.4 eV (CdTe-2.4) were previously shown to inhibit multidr
Publikováno v:
ACS Biomaterials Science & Engineering. 5:3111-3118
Quantum-confined states of semiconductor nanocrystals offer unique opportunities for selective light-activated photochemistry and generation of specific reactive oxygen (ROS) and nitrogen (RNS) spe...
Autor:
Thomas R, Aunins, Kristen A, Eller, Colleen M, Courtney, Max, Levy, Samuel M, Goodman, Prashant, Nagpal, Anushree, Chatterjee
Publikováno v:
ACS biomaterials scienceengineering. 5(9)
Nanomaterials have been extensively used in the biomedical field and have recently garnered attention as potential antimicrobial agents. Cadmium telluride quantum dots (QDs) with a bandgap of 2.4 eV (CdTe-2.4) were previously shown to inhibit multidr