Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Max, Kotlyar"'
Autor:
Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 2, Pp 1-23 (2022)
Abstract Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and bicarbonate channel in secretory epithelia with a critical role in maintaining fluid homeostasis. Mutations in CFTR are associated with Cystic Fibrosis (CF), the mo
Externí odkaz:
https://doaj.org/article/2333634eb31448bfa35a483208141fd8
Autor:
Shivanthy Pathmanathan, Zhong Yao, Paula Coelho, Robert Valla, Luka Drecun, Caroline Benz, Jamie Snider, Punit Saraon, Ingrid Grozavu, Max Kotlyar, Igor Jurisica, Morag Park, Igor Stagljar
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105419- (2022)
Summary: Met is an oncogene aberrantly activated in multiple cancers. Therefore, to better understand Met biology and its role in disease we applied the Mammalian Membrane Two-Hybrid (MaMTH) to generate a targeted interactome map of its interactions
Externí odkaz:
https://doaj.org/article/0a92c71625da4b51b6403321021367f4
Autor:
Pablo Porras, Elisabet Barrera, Alan Bridge, Noemi del-Toro, Gianni Cesareni, Margaret Duesbury, Henning Hermjakob, Marta Iannuccelli, Igor Jurisica, Max Kotlyar, Luana Licata, Ruth C. Lovering, David J. Lynn, Birgit Meldal, Bindu Nanduri, Kalpana Paneerselvam, Simona Panni, Chiara Pastrello, Matteo Pellegrini, Livia Perfetto, Negin Rahimzadeh, Prashansa Ratan, Sylvie Ricard-Blum, Lukasz Salwinski, Gautam Shirodkar, Anjalia Shrivastava, Sandra Orchard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The IMEx consortium provides one of the largest resources of curated, experimentally verified molecular interaction data. Here, the authors review how IMEx evolved into a fundamental resource for life scientists and describe how IMEx data can support
Externí odkaz:
https://doaj.org/article/1dcc4fce40a042d9b98ea3d25e21c5d2
Autor:
Chiara Pastrello, Mark Abovsky, Richard Lu, Zuhaib Ahmed, Max Kotlyar, Christian Veillette, Igor Jurisica
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 1, Pp 100237- (2022)
Objective: OsteoDIP aims to collect and provide, in a simple searchable format, curated high throughput RNA expression data related to osteoarthritis. Design: Datasets are collected annually by searching “osteoarthritis gene expression profile” i
Externí odkaz:
https://doaj.org/article/138b4f8a505840538cbdd75604aee003
Autor:
Zhong Yao, Farzaneh Aboualizadeh, Jason Kroll, Indira Akula, Jamie Snider, Anna Lyakisheva, Priscilla Tang, Max Kotlyar, Igor Jurisica, Mike Boxem, Igor Stagljar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Protein-protein interactions are fundamental to the regulation of protein activity and cellular phyisology. Here the authors present Split Intein-Mediated Protein Ligation, which uses bait and prey proteins fused to intein fragments to generate singl
Externí odkaz:
https://doaj.org/article/d7c200701845452a9c8b0403041b6f6f
Autor:
Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re
Externí odkaz:
https://doaj.org/article/9d3d9f430d2e481298f1f134583ff8b6
Autor:
Mamatha Bhat, Elisa Pasini, Chiara Pastrello, Marc Angeli, Cristina Baciu, Mark Abovsky, Angella Coffee, Oyedele Adeyi, Max Kotlyar, Igor Jurisica
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundHepatocellular Carcinoma (HCC) is a sexually dimorphic cancer, with female sex being independently protective against HCC incidence and progression. The aim of our study was to understand the mechanism of estrogen receptor signaling in driv
Externí odkaz:
https://doaj.org/article/bcad94a7b6a3471bb30f1db3e5daad2f
Autor:
Sergi Clotet-Freixas, PhD, Max Kotlyar, PhD, Caitriona M. McEvoy, MD, PhD, Chiara Pastrello, PhD, Sonia Rodríguez-Ramírez, MD, Sofia Farkona, PhD, Heloise Cardinal, MD, PhD, Mélanie Dieudé, PhD, Marie-Josée Hébert, MD, PhD, Yanhong Li, BSc, Olusegun Famure, MPH, MEd,, Peixuen Chen, HBSc, BScN, S. Joseph Kim, MD, PhD, Emilie Chan, MD, Igor Jurisica, PhD, Rohan John, MD, Andrzej Chruscinski, MD, PhD, Ana Konvalinka, MD, PhD
Publikováno v:
Transplantation Direct, Vol 7, Iss 10, p e768 (2021)
Background. Antibody-mediated rejection (AMR) causes more than 50% of late kidney graft losses. In addition to anti-human leukocyte antigen (HLA) donor-specific antibodies, antibodies against non-HLA antigens are also linked to AMR. Identifying key n
Externí odkaz:
https://doaj.org/article/ad1e0b13d49a4debb40ec96a023a64d7
Autor:
Mainak Chakraborty, Kevin Chu, Annie Shrestha, Xavier S. Revelo, Xiangyue Zhang, Matthew J. Gold, Saad Khan, Megan Lee, Camille Huang, Masoud Akbari, Fanta Barrow, Yi Tao Chan, Helena Lei, Nicholas K. Kotoulas, Juan Jovel, Chiara Pastrello, Max Kotlyar, Cynthia Goh, Evangelos Michelakis, Xavier Clemente-Casares, Pamela S. Ohashi, Edgar G. Engleman, Shawn Winer, Igor Jurisica, Sue Tsai, Daniel A. Winer
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108609- (2021)
Summary: Stiffness in the tissue microenvironment changes in most diseases and immunological conditions, but its direct influence on the immune system is poorly understood. Here, we show that static tension impacts immune cell function, maturation, a
Externí odkaz:
https://doaj.org/article/2bdc05ee448647c1a7a0d51fb5a28476
Autor:
Anne-Christin Hauschild, Chiara Pastrello, Gitta Kirana Anindya Ekaputeri, Dylan Bethune-Waddell, Mark Abovsky, Zuhaib Ahmed, Max Kotlyar, Richard Lu, Igor Jurisica
Publikováno v:
Nucleic Acids Research. 51:D217-D225
MirDIP is a well-established database that aggregates microRNA-gene human interactions from multiple databases to increase coverage, reduce bias, and improve usability by providing an integrated score proportional to the probability of the interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773323ee9bcdce72ad2f67e882b22b63
https://doi.org/10.1093/nar/gkac1070
https://doi.org/10.1093/nar/gkac1070