Computer-Aided Design of Orally Bioavailable Pyrrolidine Carboxamide Inhibitors of Enoyl-Acyl Carrier Protein Reductase of Mycobacterium tuberculosis with Favorable Pharmacokinetic Profiles

Autor: Vladimir Frecer, Yao Thomas N'Guessan, Mawa Kone, Akori Esmel, Melalie Keita, Eugene Megnassan, Affiba Florance Kouassi, Stanislav Miertus

Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 12, Pp 29744-29771 (2015)
International Journal of Molecular Sciences
Volume 16
Issue 12
Pages 29744-29771
International Journal of Molecular Sciences; Volume 16; Issue 12; Pages: 29744-29771

We have carried out a computational structure-based design of new potent pyrrolidine carboxamide (PCAMs) inhibitors of enoyl-acyl carrier protein reductase (InhA) of Mycobacterium tuberculosis (MTb). Three-dimensional (3D) models of InhA-PCAMx comple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b535e43107e629ba99a605827a7c33e
https://doi.org/10.3390/ijms161226196