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Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin.

Autor: Chan TS; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA. tom.chan@boehringer-ingelheim.com., Byer-Alcorace AJ; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA., Latli B; Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA., Liu P; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA., Maw HH; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA., Raymond KG; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA., Scaringella YS; Department of Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA., Teitelbaum AM; Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany., Wang T; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA., Whitcher-Johnstone A; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.; DMPK Oncology, AstraZeneca Inc., 35 Gatehouse Dr., Waltham, MA, 02451, USA., Taub ME; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.

Publikováno v: Pharmaceutical research [Pharm Res] 2023 Aug; Vol. 40 (8), pp. 1901-1913. Date of Electronic Publication: 2023 Jun 06.

Bioactivation and reactivity research advances - 2021 year in review.

Autor: Jackson KD; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA., Argikar UA; Non-Clinical Development, Bill & Melinda Gates Medical Research Institute, Cambridge, MA, USA., Cho S; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Crouch RD; Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, TN, USA., Driscoll JP; Department of Drug Metabolism and Pharmacokinetics, Bristol Myers Squibb, Brisbane, CA, USA., Heck CJS; Medicine Design, Pfizer Worldwide Research, Development and Medical, Groton, CT, USA., King L; Department of DMPK, UCB Biopharma UK, Slough, UK., Maw HH; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, USA., Miller GP; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Seneviratne HK; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wang S; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Wei C; Drug Metabolism & Pharmacokinetics, Biogen Inc., Cambridge, MA, USA., Zhang D; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA., Khojasteh SC; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA, USA.

Publikováno v: Drug metabolism reviews [Drug Metab Rev] 2022 Aug; Vol. 54 (3), pp. 246-281. Date of Electronic Publication: 2022 Aug 05.

N -Methylation of BI 187004 by Thiol S -Methyltransferase.

Autor: Maw HH; Drug Metabolism and Pharmacokinetics (H.H.M., M.E.T., A.M.T.), Chemical Development (X.Z.), and Material and Analytical Sciences (S.C.), Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut hlaing.maw@boehringer-ingelheim.com., Zeng X; Drug Metabolism and Pharmacokinetics (H.H.M., M.E.T., A.M.T.), Chemical Development (X.Z.), and Material and Analytical Sciences (S.C.), Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut., Campbell S; Drug Metabolism and Pharmacokinetics (H.H.M., M.E.T., A.M.T.), Chemical Development (X.Z.), and Material and Analytical Sciences (S.C.), Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut., Taub ME; Drug Metabolism and Pharmacokinetics (H.H.M., M.E.T., A.M.T.), Chemical Development (X.Z.), and Material and Analytical Sciences (S.C.), Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut., Teitelbaum AM; Drug Metabolism and Pharmacokinetics (H.H.M., M.E.T., A.M.T.), Chemical Development (X.Z.), and Material and Analytical Sciences (S.C.), Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut.

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2018 Jun; Vol. 46 (6), pp. 770-778. Date of Electronic Publication: 2018 Mar 07.