Using deep long-read RNAseq in Alzheimer's disease brain to assess medical relevance of RNA isoform diversity.

Autor: Heberle BA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY.; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY., Brandon JA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY., Page ML; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY., Nations KA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY., Dikobe KI; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY., White BJ; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY., Gordon LA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY., Fox GA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY.; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY., Wadsworth ME; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY., Doyle PH; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY.; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY., Williams BA; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY., Fox EJ; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Shantaraman A; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Ryten M; Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK., Goodwin S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States., Ghiban E; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States., Wappel R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States., Mavruk-Eskipehlivan S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, United States., Miller JB; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY.; Division of Biomedical Informatics, Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY.; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA.; Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Nelson PT; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY., Fryer JD; Department of Neuroscience, Mayo Clinic, Scottsdale, Arizona., Ebbert MTW; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY.; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY.; Division of Biomedical Informatics, Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 11. Date of Electronic Publication: 2023 Dec 11.