Whole-body MRI-based long-term evaluation of pediatric NF1 patients without initial tumor burden with evidence of newly developed peripheral nerve sheath tumors.

Autor: Schmalhofer ML; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. m.schmalhofer@uke.de., Farschtschi S; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Kluwe L; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Mautner VF; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Adam G; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Well L; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany., Ristow I; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Publikováno v: Orphanet journal of rare diseases [Orphanet J Rare Dis] 2024 Nov 04; Vol. 19 (1), pp. 412. Date of Electronic Publication: 2024 Nov 04.

Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation.

Autor: Neyazi S; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Yamazawa E; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Hack K; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Tanaka S; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Nagae G; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Kresbach C; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Umeda T; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Eckhardt A; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.; Department of Radiotherapy and Radiation Oncology, Hubertus Wald Tumor Center, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Tatsuno K; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Pohl L; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany., Hana T; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Bockmayr M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kim P; Utsunomiya Neurospine Center, Symphony Clinic, Utsunomiya, Japan., Dorostkar MM; Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany., Takami T; Department of Neurosurgery, Osaka Medical and Pharmaceutical University, Osaka, Japan., Obrecht D; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Takai K; Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Suwala AK; Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany., Komori T; Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Godbole S; Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wefers AK; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Otani R; Department of Neurosurgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan., Neumann JE; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Higuchi F; Department of Neurosurgery, University of Teikyo Hospital, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan., Schweizer L; Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt Am Main, Germany.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt Am Main, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt Am Main, Germany., Nakanishi Y; Department of Neurosurgery, Osaka Metropolitan City University Graduate School of Medicine, Osaka, Japan., Monoranu CM; Department of Neuropathology, Institute of Pathology, University of Würzburg, Würzburg, Germany., Takami H; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Engertsberger L; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Yamada K; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Ruf V; Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany., Nomura M; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Mohme T; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mukasa A; Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Herms J; Center for Neuropathology and Prion Research, Faculty of Medicine, Ludwig-Maximilians-Universität Munich, Munich, Germany., Takayanagi S; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Mynarek M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Matsuura R; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Lamszus K; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ishii K; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kluwe L; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Imai H; Department of Neurosurgery, Japan Community Health Care Organization Tokyo Shinjuku Medical Center, Tokyo, Japan., von Deimling A; Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany., Koike T; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Benesch M; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Kushihara Y; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Snuderl M; Department of Pathology, NYU Langone Health, New York City, USA., Nambu S; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Frank S; Division of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland., Omura T; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Hagel C; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kugasawa K; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Mautner VF; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ichimura K; Department of Brain Disease Translational Research, Juntendo University Graduate School of Medicine, Bunkyo-Ku, Tokyo, Japan., Rutkowski S; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Aburatani H; Genome Science and Medicine Laboratory, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Saito N; Department of Neurosurgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.; Research Institute Children's Cancer Center Hamburg, Hamburg, Germany. u.schueller@uke.de.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. u.schueller@uke.de.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2024 Jan 24; Vol. 147 (1), pp. 22. Date of Electronic Publication: 2024 Jan 24.

Atypical neurofibromas reveal distinct epigenetic features with proximity to benign peripheral nerve sheath tumor entities.

Autor: Kresbach C; Department of Diagnostics, Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg- Eppendorf, Hamburg, Germany., Dottermusch M; Department of Diagnostics, Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Germany., Eckhardt A; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany.; Lab of Radiobiology & Experimental Radiation Oncology, Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ristow I; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Paplomatas P; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany., Altendorf L; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany., Wefers AK; Department of Diagnostics, Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg- Eppendorf, Hamburg, Germany., Bockmayr M; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg- Eppendorf, Hamburg, Germany.; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Pathology, Berlin, Germany., Belakhoua S; Department of Pathology, NYU Langone Health and School of Medicine, New York, New York, USA., Tran I; Department of Pathology, NYU Langone Health and School of Medicine, New York, New York, USA., Pohl L; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany., Neyazi S; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany., Bode H; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany., Farschtschi S; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Well L; Department of Diagnostic and Interventional Radiology and Nuclear Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Friedrich RE; Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Reuss D; Department of Neuropathology, University of Heidelberg, Heidelberg, Germany., Snuderl M; Department of Pathology, NYU Langone Health and School of Medicine, New York, New York, USA., Hagel C; Department of Diagnostics, Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Germany., Mautner VF; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schüller U; Department of Diagnostics, Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Germany.; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany.

Publikováno v: Neuro-oncology [Neuro Oncol] 2023 Sep 05; Vol. 25 (9), pp. 1644-1655.

Mortality in neurofibromatosis type 2 – a multi-centre retrospective study

Autor: Lawson McLean, AC, Weigert, L, Mautner, VF, Gugel, I, Schuhmann, MU, Rosahl, S

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; 20210606-20210609; sine loco [digital]; DOCV263 /20210604/

Objective: Neurofibromatosis type 2 (NF2) is an autosomal-dominant hereditary disease characterized by multiple tumours of the central and peripheral nervous system. NF2 is associated with a considerable morbidity and mortality. However, little data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc84f4b9ac4a7fbd430ad4a3831a94d

Surgical management of peripheral nerve sheath tumours in children, with special consideration of neurofibromatoses.

Autor: Zipfel J; Division of Paediatric Neurosurgery, Department of Neurosurgery, University Hospital of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany. julian.zipfel@med.uni-tuebingen.de.; Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany. julian.zipfel@med.uni-tuebingen.de.; Centre for Neurofibromatosis at the Centre of Rare Diseases, University Hospital and University of Tübingen, Tübingen, Germany. julian.zipfel@med.uni-tuebingen.de., Al-Hariri M; Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany., Gugel I; Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany.; Centre for Neurofibromatosis at the Centre of Rare Diseases, University Hospital and University of Tübingen, Tübingen, Germany., Haas-Lude K; Centre for Neurofibromatosis at the Centre of Rare Diseases, University Hospital and University of Tübingen, Tübingen, Germany.; Department of Paediatric Neurology, University Children's Hospital Tübingen, Tübingen, Germany., Grimm A; Department of Neurology, University Hospital Tübingen, Tübingen, Germany., Warmann S; Department of Paediatric Surgery, University Children's Hospital Tübingen, Tübingen, Germany., Krimmel M; Department of Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany., Mautner VF; Neurofibromatosis Centre Hamburg, Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Tatagiba M; Division of Paediatric Neurosurgery, Department of Neurosurgery, University Hospital of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.; Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany.; Centre for Neurofibromatosis at the Centre of Rare Diseases, University Hospital and University of Tübingen, Tübingen, Germany., Schuhmann MU; Division of Paediatric Neurosurgery, Department of Neurosurgery, University Hospital of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.; Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany.; Centre for Neurofibromatosis at the Centre of Rare Diseases, University Hospital and University of Tübingen, Tübingen, Germany.

Publikováno v: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2020 Oct; Vol. 36 (10), pp. 2433-2442. Date of Electronic Publication: 2020 Jun 06.