Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mausumee Guha"'
Autor:
Mausumee Guha, Zhanna Sobol, Mathew Martin, Michelle Hemkens, Tae Sung, Elizabeth Rubitski, Richard Spellman, Martin Finkelstein, Nasir Khan, Wenyue Hu
Publikováno v:
International journal of toxicology. 41(6)
Poly(ADP-ribose) polymerase inhibitors (PARPi) are approved as monotherapies in BRCA1/2-mutated (m BRCA1/2) metastatic breast and ovarian cancers, and in advanced pancreatic and metastatic castration-resistant prostate cancers. Differential safety pr
Autor:
Brahmam Pujala, Sreekanth A. Ramachandran, Mukesh Sonawane, Maruti M. Kamble, Dayanand Panpatil, Swati Adhikari, Sanjeev Soni, Venkata Subbareddy, Bharat U. Shinde, Anjan K. Nayak, Chandni Bansal, Ashu Gupta, Kakoli Mukherjee, Anil K. Agarwal, Javier Guerrero, Francisco J. Herrera, Sebastian Bernales, Mausumee Guha, Sarvajit Chakravarty, Son M. Pham, Roopa Rai
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
Compound 1 is a potent TGF-β receptor type-1 (TGFβR1 or ALK5) inhibitor but is metabolically unstable. A solvent-exposed part of this molecule was used to analogue and modulate cell activity, liver microsome stability and mouse pharmacokinetics. Th
Publikováno v:
International Journal of Toxicology. 36:207-219
Salt forms of pharmaceutical compounds can have unique pharmacokinetic and toxicity properties. MDV1634 was evaluated for neurology indication and also demonstrated blood pressure (BP)-lowering effects in nonclinical studies. During the chemistry man
Autor:
R. Scott Obach, Ellen Evans, Nasir K. Khan, Jessica Whritenour, Changhua Ji, Susanna Tse, Xu Zhu, Michelle Hemkens, Gregory S. Walker, Martin Finkelstein, Mausumee Guha, Ernesto Callegari
Publikováno v:
Chemical research in toxicology. 33(1)
Enzalutamide and apalutamide are two androgen receptor inhibitors approved for the treatment of castration-resistant prostate cancer (CRPC) and nonmetastatic castration-resistant prostate cancer (nmCRPC), respectively. Apalutamide is associated with
Autor:
Harrison W. Farber, Nicola Wallis, Daniele Mattei, Andrew Peacock, Delphine Rea, Mausumee Guha, Neil P. Shah, Michael J. Mauro, Robert Wolf
Publikováno v:
American Journal of Hematology. 90:1060-1064
The prognosis of most leukemia patients treated with BCR-ABL tyrosine kinase inhibitors (TKIs) is favorable, and a more precise understanding of serious and potentially irreversible treatment-related toxicities is essential to properly inform treatme
Autor:
Jorge E. Cortes, Jane F. Apperley, Mausumee Guha, Nicola Wallis, Elisabetta Abruzzese, Ekaterina Chelysheva
Publikováno v:
American Journal of Hematology. 90:1111-1115
Prolonged survival in patients with chronic myeloid leukemia treated with BCR-ABL1-targeted tyrosine kinase inhibitors allows consideration of parenthood for patients on chronic therapy, but there are limited data about the effects of dasatinib on pr
Autor:
Michael J. Graziano, Mausumee Guha, Julia Li, Nicola Wallis, Damir Simic, James Hennan, Bethany R. Baumgart, Jochen Woicke, Thomas P. Sanderson, Roderick T. Bunch
Publikováno v:
Cancer chemotherapy and pharmacology. 79(4)
Pulmonary arterial hypertension (PAH) results from occlusion or vasoconstriction of pulmonary vessels, leading to progressive right ventricular failure. Dasatinib, a BCR-ABL1 tyrosine kinase inhibitor (TKI) approved for the treatment of chronic myelo
Autor:
Mausumee Guha, Long Yuan, Yifei Liu, Dara Hawthorne, Guowen Liu, Jim X Shen, Anne Aubry, Yue Zhao
Publikováno v:
Rapid Communications in Mass Spectrometry. 27:481-488
RATIONALE Nucleotide analogs are highly polar and ionic, which impose great challenges on bioanalysis. Ion-pairing liquid chromatography/tandem mass spectrometry (LC/MS/MS) is the predominant reported approach for such compounds. Assay ruggedness of
Autor:
Cathie York-Defalco, Brianna Bender, Mausumee Guha, Doreen A. Miller, Jeffrey R. Crosby, Susan Gregory, Thomas P. Condon, Brett P. Monia, Richard S. Geary, James G. Karras, David Tung
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:938-946
The B7-family molecule CD86, expressed on the surface of pulmonary and thoracic lymph node antigen-presenting cells, delivers essential costimulatory signals for T-cell activation in response to inhaled allergens. CD86-CD28 signaling is involved in p
Autor:
Neil P, Shah, Nicola, Wallis, Harrison W, Farber, Michael J, Mauro, Robert A, Wolf, Daniele, Mattei, Mausumee, Guha, Delphine, Rea, Andrew, Peacock
Publikováno v:
American journal of hematology. 90(11)
The prognosis of most leukemia patients treated with BCR-ABL tyrosine kinase inhibitors (TKIs) is favorable, and a more precise understanding of serious and potentially irreversible treatment-related toxicities is essential to properly inform treatme