Adult mouse fibroblasts retain organ-specific transcriptomic identity

Autor: Elvira Forte, Mirana Ramialison, Hieu T Nim, Madison Mara, Jacky Y Li, Rachel Cohn, Sandra L Daigle, Sarah Boyd, Edouard G Stanley, Andrew G Elefanty, John Travis Hinson, Mauro W Costa, Nadia A Rosenthal, Milena B Furtado

Publikováno v: eLife, Vol 11 (2022)

Organ fibroblasts are essential components of homeostatic and diseased tissues. They participate in sculpting the extracellular matrix, sensing the microenvironment, and communicating with other resident cells. Recent studies have revealed transcript

Externí odkaz: https://doaj.org/article/fdff1021c46d4d60aff391d8030addd1

Deletion of Nkx2-5 in trabecular myocardium reveals the developmental origins of pathological heterogeneity associated with ventricular non-compaction cardiomyopathy.

Autor: Caroline Choquet, Thi Hong Minh Nguyen, Pierre Sicard, Emeline Buttigieg, Thi Thom Tran, Frank Kober, Isabelle Varlet, Rachel Sturny, Mauro W Costa, Richard P Harvey, Catherine Nguyen, Pascal Rihet, Sylvain Richard, Monique Bernard, Robert G Kelly, Nathalie Lalevée, Lucile Miquerol

Publikováno v: PLoS Genetics, Vol 14, Iss 7, p e1007502 (2018)

Left ventricular non-compaction (LVNC) is a rare cardiomyopathy associated with a hypertrabeculated phenotype and a large spectrum of symptoms. It is still unclear whether LVNC results from a defect of ventricular trabeculae development and the mecha

Externí odkaz: https://doaj.org/article/becc5cd19dcf4db3b6b091f6db77aec0

Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5.

Autor: Mauro W Costa, Stella Lee, Milena B Furtado, Li Xin, Duncan B Sparrow, Camila G Martinez, Sally L Dunwoodie, Eleonora Kurtenbach, Tim Mohun, Nadia Rosenthal, Richard P Harvey

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24812 (2011)

Reversible post-translational protein modifications such as SUMOylation add complexity to cardiac transcriptional regulation. The homeodomain transcription factor Nkx2-5/Csx is essential for heart specification and morphogenesis. It has been previous

Externí odkaz: https://doaj.org/article/1c2b37b85f354a28911b6ff82f1e0128

Single Cell Epigenetics Reveal Cell-Cell Communication Networks in Normal and Abnormal Cardiac Morphogenesis

Autor: Sanjeev S. Ranade, Sean Whalen, Ivana Zlatanova, Tomohiro Nishino, Benjamin van Soldt, Lin Ye, Angelo Pelonero, Langley Grace Wallace, Yu Huang, Michael Alexanian, Arun Padmanabhan, Barbara Gonzalez-Teran, Pawel Przytycki, Mauro W. Costa, Casey A. Gifford, Brian L. Black, Katherine S. Pollard, Deepak Srivastava

Communication between myriad cell types during organ formation underlies proper morphogenesis1. In cardiac development, reciprocal signaling between mesoderm progenitors and neural crest cells is essential, and its disruption leads to congenital hear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::643e949c5df7fd1acbf53c7827855649
https://doi.org/10.1101/2022.07.25.501458

Transcription factor protein interactomes reveal genetic determinants in heart disease

Autor: Barbara Gonzalez-Teran, Maureen Pittman, Franco Felix, Reuben Thomas, Desmond Richmond-Buccola, Ruth Hüttenhain, Krishna Choudhary, Elisabetta Moroni, Mauro W. Costa, Yu Huang, Arun Padmanabhan, Michael Alexanian, Clara Youngna Lee, Bonnie E.J. Maven, Kaitlen Samse-Knapp, Sarah U. Morton, Michael McGregor, Casey A. Gifford, J.G. Seidman, Christine E. Seidman, Bruce D. Gelb, Giorgio Colombo, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Nevan J. Krogan, Katherine S. Pollard, Deepak Srivastava

Publikováno v: Cell, vol 185, iss 5
Cell
Cell (Cambridge) 185 (2022): 794–814.e30. doi:10.1016/j.cell.2022.01.021
info:cnr-pdr/source/autori:Gonzalez-Teran B.; Pittman M.; Felix F.; Thomas R.; Richmond-Buccola D.; Huttenhain R.; Choudhary K.; Moroni E.; Costa M.W.; Huang Y.; Padmanabhan A.; Alexanian M.; Lee C.Y.; Maven B.E.J.; Samse-Knapp K.; Morton S.U.; McGregor M.; Gifford C.A.; Seidman J.G.; Seidman C.E.; Gelb B.D.; Colombo G.; Conklin B.R.; Black B.L.; Bruneau B.G.; Krogan N.J.; Pollard K.S.; Srivastava D./titolo:Transcription factor protein interactomes reveal genetic determinants in heart disease/doi:10.1016%2Fj.cell.2022.01.021/rivista:Cell (Cambridge)/anno:2022/pagina_da:794/pagina_a:814.e30/intervallo_pagine:794–814.e30/volume:185

Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains challenging. We hypothesized that genetic determinants for CHDs may lie in the protein interactomes of transcription factors whose mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bcdf4435eb5987a378294012ffb20d0
https://escholarship.org/uc/item/00m1b8f0