Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mauro Sbroggiò"'
Autor:
María Castejón-Griñán, Eliene Albers, Lucía Simón-Carrasco, Paula Aguilera, Mauro Sbroggio, David Pladevall-Morera, Andreas Ingham, Ernest Lim, Alba Guillen-Benitez, Elena Pietrini, Michael Lisby, Ian D. Hickson, Andres J. Lopez-Contreras
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Plk1-interacting checkpoint helicase (PICH) is a DNA translocase involved in resolving ultrafine anaphase DNA bridges and, therefore, is important to safeguard chromosome segregation and stability. PICH is overexpressed in various human canc
Externí odkaz:
https://doaj.org/article/7de1b99b4f8b44b9b87279d3104a6ec4
Autor:
Eliene Albers, Mauro Sbroggiò, David Pladevall-Morera, Anna H. Bizard, Alexandra Avram, Patricia Gonzalez, Javier Martin-Gonzalez, Ian D. Hickson, Andres J. Lopez-Contreras
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3274-3284 (2018)
Summary: PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investiga
Externí odkaz:
https://doaj.org/article/149a3d169b514d959965752a637b3358
Autor:
Eliene Albers, Alexandra Avram, Andrés J. López-Contreras, Mauro Sbroggiò, Oscar Fernandez-Capetillo
Publikováno v:
Aging (Albany NY)
Albers, E, Avram, A, Sbroggio, M, Fernandez-Capetillo, O & Lopez-Contreras, A J 2020, ' Supraphysiological protection from replication stress does not extend mammalian lifespan ', Aging, vol. 12, no. 7, pp. 5612-5624 . https://doi.org/10.18632/aging.103039
Albers, E, Avram, A, Sbroggio, M, Fernandez-Capetillo, O & Lopez-Contreras, A J 2020, ' Supraphysiological protection from replication stress does not extend mammalian lifespan ', Aging, vol. 12, no. 7, pp. 5612-5624 . https://doi.org/10.18632/aging.103039
Replication Stress (RS) is a type of DNA damage generated at the replication fork, characterized by single-stranded DNA (ssDNA) accumulation, and which can be caused by a variety of factors. Previous studies have reported elevated RS levels in aged c
Autor:
Matteo Sorge, Andrea Gallo, Cristina Rubinetto, Mauro Sbroggiò, Alexandra Haute, Enrico Moiso, Saveria Femminò, Federica Zamporlini, Miriam Martini, Alessandra Ghigo, Nadia Raffaelli, Claudia Penna, Pasquale Pagliaro, Chiara Riganti, Guido Tarone, Mara Brancaccio
Publikováno v:
Vascular Pharmacology. 146:107081
Autor:
Mauro Sbroggiò, Ian D. Hickson, Patricia Gonzalez, Eliene Albers, Anna H. Bizard, David Pladevall-Morera, Alexandra Avram, Andrés J. López-Contreras, Javier Martin-Gonzalez
Publikováno v:
Albers, E, Sbroggiò, M, Pladevall-Morera, D, Bizard, A H, Avram, A, Gonzalez, P, Martin-Gonzalez, J, Hickson, I D & Lopez-Contreras, A J 2018, ' Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality ', Cell Reports, vol. 24, no. 12, pp. 3274-3284 . https://doi.org/10.1016/j.celrep.2018.08.071
Cell Reports
Cell Reports, Vol 24, Iss 12, Pp 3274-3284 (2018)
Cell Reports
Cell Reports, Vol 24, Iss 12, Pp 3274-3284 (2018)
Summary PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investigat
Autor:
Mauro Sbroggiò, Eliene Albers, Stephanie Munk, Andrés J. López-Contreras, Javier Martin-Gonzalez, Alexandra Avram
Publikováno v:
Transgenic Research. 26:429-434
The generation of genetically engineered mouse models (GEMMs), including knock-out (KO) and knock-in (KI) models, often requires genomic screening of many mouse ES cell (mESC) clones by Southern blot. The use of large targeting constructs facilitates
Autor:
Mauro Sbroggiò, Tania Papoutsi, Vanesa Bou, Gaetano D'Amato, Luis Jesús Jiménez-Borreguero, Beatriz Martínez-Poveda, Stanislao Igor Travisano, José Luis de la Pompa, Gonzalo del Monte-Nieto, Juan Miguel Redondo, Donal MacGrogan, Bin Zhou, Pablo Gómez-del Arco, Manuel Gómez, Guillermo Luxán
Publikováno v:
Circulation Research. 118:1480-1497
Rationale: The Notch signaling pathway is crucial for primitive cardiac valve formation by epithelial–mesenchymal transition, and NOTCH1 mutations cause bicuspid aortic valve; however, the temporal requirement for the various Notch ligands and rece
Autor:
Enrico Moiso, Matteo Sorge, Chiara Riganti, Saveria Femminò, Emilio Hirsch, Pasquale Pagliaro, Alessandra Ghigo, Mauro Sbroggiò, Giuseppe Digilio, Claudia Penna, Alexandra Haute, Eleonora Cavallari, Mara Brancaccio, Cristina Rubinetto, Guido Tarone, Carlo Tacchetti, James Cimino, Andrea Gallo, Andrea Raimondi
Publikováno v:
Vascular Pharmacology. 132:106749
Publikováno v:
Cellular and Molecular Life Sciences. 70:4047-4054
The ability of cardiomyocytes to detect mechanical and humoral stimuli is critical for adaptation of the myocardium in response to new conditions and for sustaining the increased workload during stress. While certain stimuli mediate a beneficial adap
Autor:
Donal MacGrogan, Beatriz Martínez-Poveda, José Luis de la Pompa, Mauro Sbroggiò, José Martínez-González, Cristina Rodríguez, Vicente Andrés, Meritxell Nus, Andrés Hidalgo, Gaetano D'Amato, Rafael Chevre
Publikováno v:
Cardiovascular research. 112(2)
Aim To determine the role of NOTCH during the arterial injury response and the subsequent chronic arterial-wall inflammation underlying atherosclerosis. Methods and results We have generated a mouse model of endothelial-specific ( Cdh5 -driven) deple