Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Mauro Santibanez‐Koref"'
Autor:
Richard Gallon, Patricia Herrero-Belmonte, Rachel Phelps, Christine Hayes, Elizabeth Sollars, Daniel Egan, Helena Spiewak, Sam Nalty, Sarah Mills, Peh Sun Loo, Gillian M. Borthwick, Mauro Santibanez-Koref, John Burn, Ciaron McAnulty, Michael S. Jackson
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-11 (2024)
Abstract Background Lynch syndrome (LS) is under-diagnosed. UK National Institute for Health and Care Excellence guidelines recommend multistep molecular testing of all colorectal cancers (CRCs) to screen for LS. However, the complexity of the pathwa
Externí odkaz:
https://doaj.org/article/a83bafbb709a45cea3903a4046c1df92
Autor:
Benjamin J. Whittle, Osagie G. Izuogu, Hannah Lowes, Dasha Deen, Angela Pyle, Jon Coxhead, Rachael A. Lawson, Alison J. Yarnall, Michael S. Jackson, Mauro Santibanez-Koref, Gavin Hudson
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Neurodegeneration in Parkinson’s disease (PD) precedes diagnosis by years. Early neurodegeneration may be reflected in RNA levels and measurable as a biomarker. Here, we present the largest quantification of whole blood linear and circular
Externí odkaz:
https://doaj.org/article/755bcb8608f34a71b0ad793489ea3d40
Autor:
Maria Rasmussen, Peter Sowter, Richard Gallon, Jon Ambæk Durhuus, Christine Hayes, Ove Andersen, Mef Nilbert, Lone Schejbel, Estrid Høgdall, Mauro Santibanez-Koref, Michael S. Jackson, John Burn, Christina Therkildsen
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionLynch syndrome-associated cancer develops due to germline pathogenic variants in one of the mismatch repair (MMR) genes, MLH1, MSH2, MSH6 or PMS2. Somatic second hits in tumors cause MMR deficiency, testing for which is used to screen for
Externí odkaz:
https://doaj.org/article/aefb11b3469d4b6386bfbc662f64a362
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-8 (2020)
Abstract Several studies have linked circulating cell-free mitochondrial DNA (ccf-mtDNA) to human disease. In particular, reduced ccf-mtDNA levels in the cerebrospinal fluid (CSF) of both Alzheimer’s and Parkinson’s disease (PD) patients have rai
Externí odkaz:
https://doaj.org/article/47e90a277f284219945fbc748d27d99f
Autor:
Osagie G. Izuogu, Abd A. Alhasan, Carla Mellough, Joseph Collin, Richard Gallon, Jonathon Hyslop, Francesco K. Mastrorosa, Ingrid Ehrmann, Majlinda Lako, David J. Elliott, Mauro Santibanez-Koref, Michael S. Jackson
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-18 (2018)
Abstract Background Circular RNAs (circRNAs) are predominantly derived from protein coding genes, and some can act as microRNA sponges or transcriptional regulators. Changes in circRNA levels have been identified during human development which may be
Externí odkaz:
https://doaj.org/article/8c87499476a8408397e9f43c2b37692e
Autor:
Ingrid Ehrmann, Matthew R. Gazzara, Vittoria Pagliarini, Caroline Dalgliesh, Mahsa Kheirollahi-Chadegani, Yaobo Xu, Eleonora Cesari, Marina Danilenko, Marie Maclennan, Kate Lowdon, Tanja Vogel, Piia Keskivali-Bond, Sara Wells, Heather Cater, Philippe Fort, Mauro Santibanez-Koref, Silvia Middei, Claudio Sette, Gavin J. Clowry, Yoseph Barash, Mark O. Cunningham, David J. Elliott
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3269-3280 (2016)
The brain is made up of trillions of synaptic connections that together form neural networks needed for normal brain function and behavior. SLM2 is a member of a conserved family of RNA binding proteins, including Sam68 and SLM1, that control splicin
Externí odkaz:
https://doaj.org/article/f0ae21a2845440f5b5bb4825a77a395e
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218878 (2019)
Prescription of direct oral anticoagulants (DOAC) compared to warfarin for treating atrial fibrillation patients have increased substantially since their introduction in the England's National Health Service. Assessment of the risk of strokes and ble
Externí odkaz:
https://doaj.org/article/87171517c12544bb96ff4461e4f424e3
Autor:
Rachael E. Redgrave, Simon Tual-Chalot, Benjamin J. Davison, Elizabeth Greally, Mauro Santibanez-Koref, Jurgen E. Schneider, Andrew M. Blamire, Helen M. Arthur
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 11, Iss C, Pp 29-34 (2016)
Background: Mice are frequently used in research to examine outcomes of myocardial infarction (MI) and to investigate therapeutic interventions at an early pre-clinical stage. The MI model is generated by surgically occluding a major coronary artery,
Externí odkaz:
https://doaj.org/article/f3a4dcba75044e52891034366c23532c
Autor:
Lisa Redford, Ghanim Alhilal, Stephanie Needham, Ottie O'Brien, Julie Coaker, John Tyson, Leonardo Maldaner Amorim, Iona Middleton, Osagi Izuogu, Mark Arends, Anca Oniscu, Ángel Miguel Alonso, Sira Moreno Laguna, Richard Gallon, Harsh Sheth, Mauro Santibanez-Koref, Michael S Jackson, John Burn
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203052 (2018)
Somatic mutations in mononucleotide repeats are commonly used to assess the mismatch repair status of tumours. Current tests focus on repeats with a length above 15bp, which tend to be somatically more unstable than shorter ones. These longer repeats
Externí odkaz:
https://doaj.org/article/3e880ba13c9140f9962856f4f8dc8fd2
Autor:
Harsh Sheth, Emma Northwood, Cornelia M Ulrich, Dominique Scherer, Faye Elliott, Jennifer H Barrett, David Forman, C Roland Wolf, Gillian Smith, Michael S Jackson, Mauro Santibanez-Koref, Robert Haile, Graham Casey, Mark Jenkins, Aung Ko Win, John L Hopper, Loic Le Marchand, Noralane M Lindor, Stephen N Thibodeau, John D Potter, John Burn, D Timothy Bishop
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192223 (2018)
Regular aspirin use is associated with reduced risk of colorectal cancer (CRC). Variation in aspirin's chemoprevention efficacy has been attributed to the presence of single nucleotide polymorphisms (SNPs). We conducted a meta-analysis using two larg
Externí odkaz:
https://doaj.org/article/25cf25e0d3334bcf89715c62ab971db7