Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Mauro Salvi"'
Autor:
Christian Borgo, Claudio D’Amore, Valeria Capurro, Valeria Tomati, Nicoletta Pedemonte, Valentina Bosello Travain, Mauro Salvi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2302 (2024)
Cystic fibrosis (CF) is a genetic disorder caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), a selective anion channel expressed in the epithelium of various organs. The most frequent mutation is
Externí odkaz:
https://doaj.org/article/702d8d2bfd5f432b8c99090e87508a7b
Autor:
Christian Borgo, Luca Cesaro, Tsuyoshi Hirota, Keiko Kuwata, Claudio D'Amore, Thomas Ruppert, Renata Blatnik, Mauro Salvi, Lorenzo A. Pinna
Publikováno v:
Open Biology, Vol 13, Iss 2 (2023)
CK2 is a Ser/Thr protein kinase composed of two catalytic (α/α′) subunits and a non-catalytic β-subunit dimer, whose activity is often abnormally high in cancer cells. The concept that CK2 may be dispensable for cell survival has been challenged
Externí odkaz:
https://doaj.org/article/e36dc2babf134a15b5e287ca10ab20e3
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-5 (2021)
Abstract CK2 is a protein kinase involved in several human diseases (ranging from neurological and cardiovascular diseases to autoimmune disorders, diabetes, and infections, including COVID-19), but its best-known implications are in cancer, where it
Externí odkaz:
https://doaj.org/article/1c83afc10fd14c62b2aade8c5b174e0c
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-20 (2021)
Abstract CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regul
Externí odkaz:
https://doaj.org/article/4e2233794ece4f208ef8e20378e774a9
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9612 (2022)
Cystic fibrosis (CF) is caused by mutations in the gene encoding of the cystic fibrosis transmembrane conductance regulator (CFTR), an anion-selective plasma membrane channel that mainly regulates chloride transport in a variety of epithelia. More th
Externí odkaz:
https://doaj.org/article/b521b2330b8b4cd5a812321aa9db6762
Autor:
Estefania Alcaraz, Jordi Vilardell, Christian Borgo, Eduard Sarró, Maria Plana, Oriano Marin, Lorenzo A Pinna, José R Bayascas, Anna Meseguer, Mauro Salvi, Emilio Itarte, Maria Ruzzene
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227340 (2020)
The PI3K/Akt pathway is interconnected to protein kinase CK2, which directly phosphorylates Akt1 at S129. We have previously found that, in HK-2 renal cells, downregulation of the CK2 regulatory subunit β (shCK2β cells) reduces S129 Akt phosphoryla
Externí odkaz:
https://doaj.org/article/69543d1d78a64740811782633ddbd0bf
Autor:
Rikke H. Kofoed, Jin Zheng, Nelson Ferreira, Søren Lykke-Andersen, Mauro Salvi, Cristine Betzer, Lasse Reimer, Torben Heick Jensen, Karina Fog, Poul H. Jensen
Publikováno v:
Neurobiology of Disease, Vol 106, Iss , Pp 49-62 (2017)
Variations in the α-synuclein-encoding SNCA gene represent the greatest genetic risk factor for Parkinson's disease (PD), and duplications/triplications of SNCA cause autosomal dominant familial PD. These facts closely link brain levels of α-synucl
Externí odkaz:
https://doaj.org/article/bfab553617ee493ba6b5df1c23f583c4
Autor:
Alla Piirsoo, Marko Piirsoo, Martin Kala, Eve Sankovski, Elina Lototskaja, Viktor Levin, Mauro Salvi, Mart Ustav
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007788 (2019)
Inhibition of human papillomavirus (HPV) replication is a promising therapeutic approach for intervening with HPV-related pathologies. Primary targets for interference are two viral proteins, E1 and E2, which are required for HPV replication. Both E1
Externí odkaz:
https://doaj.org/article/ffc92dc25ef8413e99a27cf3c913a069
Autor:
Claudio D’Amore, Mauro Salvi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2232 (2021)
The making of a protein is based on the combination of 20 different monomers (22 considering selenocysteine and pyrrolysine, the latest present only in some archaea and bacteria) giving the possibility of building a variety of structures from the sim
Externí odkaz:
https://doaj.org/article/37425ab181044d30b4874e951f15a5ab
Autor:
Francesca Zonta, Christian Borgo, Camila Paz Quezada Meza, Ionica Masgras, Andrea Rasola, Mauro Salvi, Lorenzo A. Pinna, Maria Ruzzene
Publikováno v:
Cells, Vol 10, Iss 1, p 181 (2021)
CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α’) and two regulatory (β) subunits, but it is active also in its monomeric form, and the speci
Externí odkaz:
https://doaj.org/article/25324a922bfd41e3bf4eb655bf940954