Herpes Simplex Virus-type1 (HSV-1) Impairs DNA Repair in Cortical Neurons

Autor: Giovanna De Chiara, Mauro Racaniello, Cristiana Mollinari, Maria Elena Marcocci, Giorgia Aversa, Alessio Cardinale, Anna Giovanetti, Enrico Garaci, Anna Teresa Palamara, Daniela Merlo

Publikováno v: Frontiers in Aging Neuroscience, Vol 8 (2016)

Several findings suggest that HSV-1 infection plays a role in the neurodegenerative processes that characterize Alzheimer’s disease, but the underlying mechanisms have yet to be fully elucidated. Here we show that HSV-1 productive infection in cort

Externí odkaz: https://doaj.org/article/dadbfb689b744248b3b6f89f553c736d

Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response

Autor: Enrico Garaci, Maria Chiara de Stefano, Cristiana Mollinari, Alessio Cardinale, Mauro Racaniello, Daniela Merlo

Publikováno v: Neurochemical research (2015). doi:10.1007/s11064-014-1465-1
info:cnr-pdr/source/autori:Cardinale A.; De Stefano M.C.; Mollinari C.; Racaniello M.; Garaci E.; Merlo D./titolo:Biochemical Characterization of Sirtuin 6 in the Brain and Its Involvement in Oxidative Stress Response/doi:10.1007%2Fs11064-014-1465-1/rivista:Neurochemical research/anno:2015/pagina_da:/pagina_a:/intervallo_pagine:/volume

Sirtuin 6 (SIRT6) is a member of nicotinamide adenine dinucleotide-dependent deacetylase protein family and has been implicated in the control of glucose and lipid metabolism, cancer, genomic stability and DNA repair. Moreover, SIRT6 regulates the ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8748102759e6b975ba07441cd435c8
https://doi.org/10.1007/s11064-014-1465-1

The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease

Autor: Eugenia Dogliotti, Daniela Merlo, Valeria Simonelli, Mauro Racaniello, Alessio Cardinale, Eleonora Parlanti, Laura Narciso

Publikováno v: Neural Plasticity, Vol 2016 (2016)
Neural Plasticity

There is a growing body of evidence indicating that the mechanisms that control genome stability are of key importance in the development and function of the nervous system. The major threat for neurons is oxidative DNA damage, which is repaired by t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e3df5b1188aa60e3c63a6fbab78e1b
https://doaj.org/article/40a674375f734c83a4f7dda741815143

DNA Double Strand Breaks: A Common Theme in Neurodegenerative Diseases

Autor: Cristiana Mollinari, Alessio Cardinale, Daniela Merlo, Mauro Racaniello, Enrico Garaci

Publikováno v: Current Alzheimer research. 13(11)

Accumulation of DNA damage and impairment of DNA repair systems are involved in the pathogenesis of different neurodegenerative diseases. Whenever DNA damage is too extensive, the DNA damage response pathway provides for triggering cellular senescenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b13cfedbae3d66f831b28282abbe04
https://pubmed.ncbi.nlm.nih.gov/27033054

Phosphorylation changes of CaMKII, ERK1/2, PKB/Akt kinases and CREB activation during early long-term potentiation at Schaffer collateral-CA1 mouse hippocampal synapses

Autor: Virginia Tancredi, Daniela Merlo, Cristiana Mollinari, Alessio Cardinale, Margherita D'Antuono, Giovanna De Chiara, Mauro Racaniello

Publikováno v: Neurochemical research 35 (2010): 239–246. doi:10.1007/s11064-009-0047-0
info:cnr-pdr/source/autori:Racaniello M.1,2; Cardinale A.1; Mollinari C.3,4; D'Antuono M.2; De Chiara G.3; Tancredi V.2; Merlo D.1,3/titolo:Phosphorylation changes of CaMKII, ERK1%2F2, PKB%2FAkt kinases and CREB activation during early long-term potentiation at Schaffer collateral-CA1 mouse hippocampal synapses/doi:10.1007%2Fs11064-009-0047-0/rivista:Neurochemical research/anno:2010/pagina_da:239/pagina_a:246/intervallo_pagine:239–246/volume:35

Protein phosphorylation is the main signaling system known to trigger synaptic changes underlying long-term potentiation (LTP). The timing of these phosphorylations plays an essential role to maintain the potentiated state of synapses. However, in mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c57efccd73add1bc4cfeed41e783374
https://publications.cnr.it/doc/166916