Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Mauro Niso"'
Autor:
Alisa A. Nevskaya, Rosa Purgatorio, Tatiana N. Borisova, Alexey V. Varlamov, Lada V. Anikina, Arina Yu. Obydennik, Elena Yu. Nevskaya, Mauro Niso, Nicola A. Colabufo, Antonio Carrieri, Marco Catto, Modesto de Candia, Leonid G. Voskressensky, Cosimo D. Altomare
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 539 (2024)
Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in some tumor cells and may
Externí odkaz:
https://doaj.org/article/2d6fcacd9a5e4820a808bb200d14b6c9
Autor:
Bashar M. Thejer, Vittoria Infantino, Anna Santarsiero, Ilaria Pappalardo, Francesca S. Abatematteo, Sarah Teakel, Ashleigh Van Oosterum, Robert H. Mach, Nunzio Denora, Byung Chul Lee, Nicoletta Resta, Rosanna Bagnulo, Mauro Niso, Marialessandra Contino, Bianca Montsch, Petra Heffeter, Carmen Abate, Michael A. Cahill
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6381 (2023)
Sigma-2 receptor (S2R) is a S2R ligand-binding site historically associated with reportedly 21.5 kDa proteins that have been linked to several diseases, such as cancer, Alzheimer’s disease, and schizophrenia. The S2R is highly expressed in various
Externí odkaz:
https://doaj.org/article/62c9cbd125aa40c5bb0a69a3f26b203b
Autor:
Carmen Abate, Mauro Niso, Francesca Serena Abatematteo, Marialessandra Contino, Nicola Antonio Colabufo, Francesco Berardi
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
These unprecedented times have forced the scientific community to gather to face the COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team has focused on the identification of the host (human) proteins interacting w
Externí odkaz:
https://doaj.org/article/b9551cfc337641e990698ea4339ee08a
Autor:
Dario P. Anobile, Mauro Niso, Adrian Puerta, Stephanie M. Fraga Rodrigues, Francesca S. Abatematteo, Amir Avan, Carmen Abate, Chiara Riganti, Elisa Giovannetti
Publikováno v:
Molecules, Vol 27, Iss 5, p 1682 (2022)
A new sigma-2 (σ2) receptor ligand (FA4) was efficiently synthesized and evaluated for cytotoxic, proapoptotic, and antimigratory activity on pancreatic ductal adenocarcinoma (PDAC) primary cell cultures, which restrained the aggressive and chemores
Externí odkaz:
https://doaj.org/article/77d58d0d3450434baa4df90017374e7e
Autor:
Margherita Mastromarino, Mauro Niso, Carmen Abate, Ewgenij Proschak, Mariam Dubiel, Holger Stark, Marián Castro, Enza Lacivita, Marcello Leopoldo
Publikováno v:
Molecules, Vol 27, Iss 4, p 1297 (2022)
Long-chain arylpiperazine scaffold is a versatile template to design central nervous system (CNS) drugs that target serotonin and dopamine receptors. Here we describe the synthesis and biological evaluation of ten new arylpiperazine derivatives desig
Externí odkaz:
https://doaj.org/article/e03fb4ce8fd04f57bd7789c1a958706f
Autor:
Francesca Serena Abatematteo, Mauro Niso, Marialessandra Contino, Marcello Leopoldo, Carmen Abate
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6359 (2021)
The sigma-1 (σ1) receptor is a ‘pluripotent chaperone’ protein mainly expressed at the mitochondria–endoplasmic reticulum membrane interfaces where it interacts with several client proteins. This feature renders the σ1 receptor an ideal targe
Externí odkaz:
https://doaj.org/article/300a3fd8d98d451f834f21f8594c3d9d
Publikováno v:
Molecules, Vol 26, Iss 12, p 3743 (2021)
Sigma-2 (σ2) is an endoplasmic receptor identified as the Endoplasmic Reticulum (ER) transmembrane protein TMEM97. Despite its controversial identity, which was only recently solved, this protein has gained scientific interest because of its role in
Externí odkaz:
https://doaj.org/article/3b452d9c54d34a8fbbf2b27ce596c96a
Autor:
Alessandra Tempio, Mauro Niso, Luna Laera, Lucia Trisolini, Maria Favia, Lucia Ciranna, Domenico Marzulli, Giuseppe Petrosillo, Ciro Leonardo Pierri, Enza Lacivita, Marcello Leopoldo
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9629 (2020)
Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT)
Externí odkaz:
https://doaj.org/article/7081d6abe1c84f379d02e5cccade3cea
Autor:
Nicola A. Colabufo, Francesco Berardi, Marialessandra Contino, Mauro Niso, Roberto Perrone, Vincenzo Tortorella
Publikováno v:
ARKIVOC, Vol 2006, Iss 8, Pp 95-101 (2006)
Externí odkaz:
https://doaj.org/article/59cf1948668f4724af2a7fab1e7e7459
Autor:
Francesca Serena Abatematteo, Maria Majellaro, Bianca Montsch, Rubén Prieto-Díaz, Mauro Niso, Marialessandra Contino, Angela Stefanachi, Chiara Riganti, Giuseppe Felice Mangiatordi, Pietro Delre, Petra Heffeter, Eddy Sotelo, Carmen Abate
Publikováno v:
Journal of Medicinal Chemistry. 66:3798-3817