Synthesis of dicarba-cyclooctapeptide Somatostatin analogs by conventional and MW-assisted RCM: A study about the impact of the configuration at C α of selected amino acids

Autor: Alfonso Carotenuto, Anna Maria Papini, Diego Brancaccio, Giuseppina Sabatino, Samuele Stazzoni, Marco Chinol, Mauro Ginanneschi, Paolo Rovero, Marco Lumini, Alessandro Pratesi, Ettore Novellino

Publikováno v: Chemical engineering and processing
122 (2017): 365–372. doi:10.1016/j.cep.2017.02.005
info:cnr-pdr/source/autori:Pratesi A.; Stazzoni S.; Lumini M.; Sabatino G.; Carotenuto A.; Brancaccio D.; Novellino E.; Chinol M.; Rovero P.; Ginanneschi M.; Papini A.M./titolo:Synthesis of dicarba-cyclooctapeptide Somatostatin analogs by conventional and MW-assisted RCM: A study about the impact of the configuration at C? of selected amino acids/doi:10.1016%2Fj.cep.2017.02.005/rivista:Chemical engineering and processing (Print)/anno:2017/pagina_da:365/pagina_a:372/intervallo_pagine:365–372/volume:122

This work describes the synthesis of thirteen cyclooctapeptides dicarba-analogues of Somatostatin, containing l- or d-allylglycine (Agl) residues at the termini of the peptide chain, through on resin Ring Closing Metathesis (RCM) of the linear octape

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7379a30f423e837c8a6c3d550c178220
https://doi.org/10.1016/j.cep.2017.02.005

Novel Octreotide Dicarba-analogues with High Affinity and Different Selectivity for Somatostatin Receptors

Autor: Alessandra Di Cianni, Anna Maria Papini, Diego Brancaccio, Jean Claude Reubi, Mauro Ginanneschi, Karin Beetschen, Alfonso Carotenuto, Ettore Novellino

Publikováno v: Journal of Medicinal Chemistry. 53:6188-6197

A limited set of novel octreotide dicarba-analogues with non-native aromatic side chains in positions 7 and/or 10 were synthesized. Their affinity toward the ssts1-5 was determined. Derivative 4 exhibited a pan-somatostatin activity, except sst4, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ce6c1952f2ead13e03b864ecee2c24
https://doi.org/10.1021/jm1005868

Short-chain oligopeptides with copper(II) binding properties: The impact of specific structural modifications on the copper(II) coordination abilities

Autor: Mauro Ginanneschi, Jolanta Świątek-Kozłowska, Agnieszka Matera-Witkiewicz, Justyna Brasuń, Luigi Messori, Alessandro Pratesi

Publikováno v: Journal of Inorganic Biochemistry. 103:678-688

A series of linear tetrapeptides containing two histidyl residues in position 2 and 4, namely DHGH, DHGdH, KHGH, KHGdH, Ac-DHGH-NH(2), Ac-DHGdH-NH(2), Ac-KHGH-NH(2), and Ac-KHGdH-NH(2), were synthesized and characterised. Their copper(II) binding pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f259441fc35c3c981771c5cda91e2d
https://doi.org/10.1016/j.jinorgbio.2009.01.001

Synthesis of a Dicarba-Analog of Octreotide Keeping the Type II β -Turn of the Pharmacophore in Water Solution

Autor: Alfonso Carotenuto, Paolo Rovero, Debora D 'Addona, Anna Maria Papini, Mauro Ginanneschi, Eleonora Rivalta, Mario Chelli

Publikováno v: Letters in Organic Chemistry. 2:274-279

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e080206f16b03593f73051a6896f0798
https://doi.org/10.2174/1570178053765276

Synthesis of lipopeptides of the immunodominant epitope hMBP(83–99) containing amide or C-C bond linked hydrophobic chains for the study of T cell response

Autor: G. Rapi, Luca Massacesi, Marco Vergelli, Mario Chelli, Elena Nardi, Anna Maria Papini, Luigi Amaducci, Benedetta Mazzanti, Silvia Mazzucco, Mauro Ginanneschi

Publikováno v: Letters in Peptide Science. 6:51-59

We previously demonstrated that the lipopeptide of the myelin basic protein (MBP) immunodominant epitope in Lewis rat Palm-GpMBP(74-85) (Gp: guinea pig), which induced experimental autoimmune encephalomyelitisin vivo strongly increased the T cell pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59b1457d46178e4756826c858c38a7a6
https://doi.org/10.1007/bf02443618