Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Mauro Freccero"'
Autor:
Valentina Pirota, Enrico Lunghi, Alessandra Benassi, Emmanuele Crespan, Mauro Freccero, Filippo Doria
Publikováno v:
Molecules, Vol 26, Iss 16, p 5025 (2021)
G-quadruplexes (G4s) are higher-order supramolecular structures, biologically important in the regulation of many key processes. Among all, the recent discoveries relating to RNA-G4s, including their potential involvement as antiviral targets against
Externí odkaz:
https://doaj.org/article/c8a0fe8cd7f548619ee1dc9f9ca1239b
Autor:
Ana Miljkovic, Sonia La Cognata, Greta Bergamaschi, Mauro Freccero, Antonio Poggi, Valeria Amendola
Publikováno v:
Molecules, Vol 25, Iss 7, p 1733 (2020)
In this work, we report the synthesis of a new bis(tris(2-aminoethyl)amine) azacryptand L with triphenyl spacers. The binding properties of its dicopper complex for aromatic dicarboxylate anions (as TBA salts) were investigated, with the aim to obtai
Externí odkaz:
https://doaj.org/article/3f3e4bee42754626a862049ae9caf2c1
Autor:
Chiara Platella, Valentina Pirota, Domenica Musumeci, Federica Rizzi, Sara Iachettini, Pasquale Zizza, Annamaria Biroccio, Mauro Freccero, Daniela Montesarchio, Filippo Doria
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1964 (2020)
A focused library of newly designed monomeric and dimeric naphthalene diimides (NDIs) was analyzed in its ability to recognize specific G-quadruplex (G4) structures discriminating duplex DNA. The best G4 ligands—according to an affinity chromatogra
Externí odkaz:
https://doaj.org/article/959436172dfc438399c8b2c2d8faf52f
Autor:
Ilda D’Annessa, Naama Hurwitz, Valentina Pirota, Giovanni Luca Beretta, Stella Tinelli, Mark Woodford, Mauro Freccero, Mehdi Mollapour, Nadia Zaffaroni, Haim Wolfson, Giorgio Colombo
Publikováno v:
Molecules, Vol 25, Iss 2, p 360 (2020)
The molecular chaperone Hsp90 is a ubiquitous ATPase-directed protein responsible for the activation and structural stabilization of a large clientele of proteins. As such, Hsp90 has emerged as a suitable candidate for the treatment of a diverse set
Externí odkaz:
https://doaj.org/article/5c05d11695af4b328f06b21e505acc77
Autor:
Marta Recagni, Martina Tassinari, Filippo Doria, Graziella Cimino-Reale, Nadia Zaffaroni, Mauro Freccero, Marco Folini, Sara N. Richter
Publikováno v:
Cells, Vol 8, Iss 10, p 1274 (2019)
Melanoma is the most aggressive and deadly type of skin cancer. Despite the advent of targeted therapies directed against specific oncogene mutations, melanoma remains a tumor that is very difficult to treat, and ultimately remains incurable. In the
Externí odkaz:
https://doaj.org/article/e0f8297700c44f0f884ee03a444f0fc8
Autor:
Filippo Doria, Valentina Pirota, Michele Petenzi, Marie-Paule Teulade-Fichou, Daniela Verga, Mauro Freccero
Publikováno v:
Molecules, Vol 23, Iss 9, p 2162 (2018)
Non-macrocyclic heteroaryls represent a valuable class of ligands for nucleic acid recognition. In this regard, non-macrocyclic pyridyl polyoxazoles and polyoxadiazoles were recently identified as selective G-quadruplex stabilizing compounds with hig
Externí odkaz:
https://doaj.org/article/cbe4c53f58154394bd955ecd5829c816
Autor:
Martina Tassinari, Alberto Lena, Elena Butovskaya, Valentina Pirota, Matteo Nadai, Mauro Freccero, Filippo Doria, Sara N. Richter
Publikováno v:
Molecules, Vol 23, Iss 8, p 1874 (2018)
G-quadruplex (G4) nucleic acid structures have been reported to be involved in several human pathologies, including cancer, neurodegenerative disorders and infectious diseases; however, G4 targeting compounds still need implementation in terms of dru
Externí odkaz:
https://doaj.org/article/ebd6831e26a443638228e5c849ece70b
Publikováno v:
Journal of Chemical Theory and Computation. 18:4515-4528
Molecular dynamics (MD) simulations are coming of age in the study of nucleic acids, including specific tertiary structures such as G-quadruplexes. While being precious for providing structural and dynamic information inaccessible to experiments at t
Autor:
Rubén Cebrián, Efres Belmonte-Reche, Valentina Pirota, Anne de Jong, Juan Carlos Morales, Mauro Freccero, Filippo Doria, Oscar P. Kuipers
Publikováno v:
Journal of Medicinal Chemistry, 65(6), 4752-4766. AMER CHEMICAL SOC
Guanidine DNA quadruplex (G4-DNA) structures convey a distinctive layer of epigenetic information that is critical for regulating key biological activities and processes as transcription, replication, and repair in living cells. The information regar
Autor:
Alakbar E. Huseynzada, Christian Jelch, Haji Vahid N. Akhundzada, Sarra Soudani, Cherif Ben Nasr, Aygun Israyilova, Filippo Doria, Ulviyya A. Hasanova, Rana F. Khankishiyeva, Mauro Freccero
Publikováno v:
RSC Advances
RSC Advances, Royal Society of Chemistry, 2021, pp.6312-6329. ⟨10.1039/D0RA10255E⟩
RSC Advances, Royal Society of Chemistry, 2021, pp.6312-6329. ⟨10.1039/D0RA10255E⟩
The syntheses and investigations of new biologically active derivatives of dihydropyrimidines by Biginelli reaction in the presence of copper triflate are reported. Due to the fact that salicylaldehyde and its derivatives under Biginelli reaction con