Melatonin-Induced Temporal Up-Regulation of Gene Expression Related to Ubiquitin/Proteasome System (UPS) in the Human Malaria Parasite Plasmodium falciparum

Autor: Fernanda C. Koyama, Mauro F. Azevedo, Alexandre Budu, Debopam Chakrabarti, Célia R. S. Garcia

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22320-22330 (2014)

There is an increasing understanding that melatonin and the ubiquitin/ proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes,

Externí odkaz: https://doaj.org/article/00debcdc03944fd3985afac1793ea463

Exploring Ubiquinone Biosynthesis Inhibition as a Strategy for Improving Atovaquone Efficacy in Malaria

Autor: Rodrigo A.C. Sussmann, Fernando G. de Almeida, Mauro F Azevedo, Emilia A. Kimura, H R Melo, Marcell Crispim, C A Zafra, Ignasi Bofill Verdaguer, Alejandro M. Katzin, N L Buriticá

Publikováno v: Antimicrob Agents Chemother

Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH(2)) for its union to the mitochondrial bc(1) complex, preventing the ubiquinone-8 and ubiquinone-9 (UQ-8 and UQ-9) redox recycling, which is a necessary step in pyrimidine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be3ad2bf42c03fd69cd8aa66e00d376
https://doi.org/10.1128/aac.01516-20

Overexpression of Plasmodium falciparum M1 Aminopeptidase Promotes an Increase in Intracellular Proteolysis and Modifies the Asexual Erythrocytic Cycle Development

Autor: Pollyana M.S. Melo, Marcos L. Gazarini, Adriana B Thurler, Mauro F Azevedo, Jorge González-Bacerio, Sarah El Chamy Maluf, Adriana K. Carmona, Alexandre Budu, Carolina Caldas Hoff, Maday Alonso del Rivero

Publikováno v: Pathogens
Volume 10
Issue 11
Pathogens, Vol 10, Iss 1452, p 1452 (2021)

Plasmodium falciparum, the most virulent of the human malaria parasite, is responsible for high mortality rates worldwide. We studied the M1 alanyl-aminopeptidase of this protozoan (PfA-M1), which is involved in the final stages of hemoglobin cleavag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aadb9879f3ec998c8b3dc3770050d5
https://doi.org/10.3390/pathogens10111452

Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate

Autor: Alejandro M. Katzin, Mauro F Azevedo, Emilia A. Kimura, Heloisa B. Gabriel

Publikováno v: Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 10 (2018)
Memórias do Instituto Oswaldo Cruz, Volume: 113, Issue: 10, Article number: e180174, Published: 13 AUG 2018

Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e785027fe6cba0746106c4e8277630e
https://doi.org/10.1590/0074-02760180174

Knockdown of the Plasmodium falciparum SURFIN4.1 antigen leads to an increase of its cognate transcript

Autor: Tatiane Macedo-Silva, Wesley Luzetti Fotoran, Mauro F Azevedo, Gerhard Wunderlich, Kamila Anna Meissner, Márcia Melo Medeiros, Rosana Beatriz Duque Araujo

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 8, p e0183129 (2017)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The genome of the malaria parasite Plasmodium falciparum contains the surf gene family which encodes large transmembrane proteins of unknown function. While some surf alleles appear to be expressed in sexual stages, others occur in asexual blood stag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e669c0c9b0de48ab9c7af58b6f7418
http://europepmc.org/articles/PMC5553854