Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mauro F, Azevedo"'
Autor:
Carolina C. Hoff, Mauro F. Azevedo, Adriana B. Thurler, Sarah El Chamy Maluf, Pollyana M. S. Melo, Maday Alonso del Rivero, Jorge González-Bacerio, Adriana K. Carmona, Alexandre Budu, Marcos L. Gazarini
Publikováno v:
Pathogens, Vol 10, Iss 11, p 1452 (2021)
Plasmodium falciparum, the most virulent of the human malaria parasite, is responsible for high mortality rates worldwide. We studied the M1 alanyl-aminopeptidase of this protozoan (PfA-M1), which is involved in the final stages of hemoglobin cleavag
Externí odkaz:
https://doaj.org/article/a0d20a6310e044c2a2d8837dadf331db
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 113, Iss 10 (2018)
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we s
Externí odkaz:
https://doaj.org/article/070f78d6ac6e47c78c42ae26b0270cfd
Autor:
Carolina C, Hoff, Mauro F, Azevedo, Adriana B, Thurler, Sarah El Chamy, Maluf, Pollyana M S, Melo, Maday Alonso, Del Rivero, Jorge, González-Bacerio, Adriana K, Carmona, Alexandre, Budu, Marcos L, Gazarini
Publikováno v:
Pathogens
Plasmodium falciparum, the most virulent of the human malaria parasite, is responsible for high mortality rates worldwide. We studied the M1 alanyl-aminopeptidase of this protozoan (PfA-M1), which is involved in the final stages of hemoglobin cleavag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5776111638b225106e2acc873201cc63
https://pubmed.ncbi.nlm.nih.gov/34832608
https://pubmed.ncbi.nlm.nih.gov/34832608
Autor:
Mauro F Azevedo, Catherine Q Nie, Brendan Elsworth, Sarah C Charnaud, Paul R Sanders, Brendan S Crabb, Paul R Gilson
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112571 (2014)
Drug discovery is a key part of malaria control and eradication strategies, and could benefit from sensitive and affordable assays to quantify parasite growth and to help identify the targets of potential anti-malarial compounds. Bioluminescence, ach
Externí odkaz:
https://doaj.org/article/e22dc4da0f204f41a369e9e8435d12dc
Autor:
Rodrigo A.C. Sussmann, Fernando G. de Almeida, Mauro F Azevedo, Emilia A. Kimura, H R Melo, Marcell Crispim, C A Zafra, Ignasi Bofill Verdaguer, Alejandro M. Katzin, N L Buriticá
Publikováno v:
Antimicrob Agents Chemother
Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH(2)) for its union to the mitochondrial bc(1) complex, preventing the ubiquinone-8 and ubiquinone-9 (UQ-8 and UQ-9) redox recycling, which is a necessary step in pyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be3ad2bf42c03fd69cd8aa66e00d376
https://doi.org/10.1128/aac.01516-20
https://doi.org/10.1128/aac.01516-20
Autor:
Andrea Soares-Costa, Thaysa Paschoalin, Alexandre Budu, Mauro F Azevedo, Sarah El Chamy Maluf, Pollyana M.S. Melo, Piero Bagnaresi, Marcos L. Gazarini, Flávio Henrique-Silva, Adriana K. Carmona
Publikováno v:
Parasitology International. 67:233-236
Malaria is a disease caused by Plasmodium parasites that affects hundreds of millions of people. Plasmodium proteases are involved in invasion, erythrocyte egress and degradation of host proteins. Falcipains are well-studied cysteine peptidases locat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ccfece094de8ffc60480d03e71e888
https://doi.org/10.1016/j.parint.2017.12.005
https://doi.org/10.1016/j.parint.2017.12.005
Autor:
Luciana Madeira, Pedro A F Galante, Alexandre Budu, Mauro F Azevedo, Bettina Malnic, Célia R S Garcia
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1889 (2008)
Serpentine receptors comprise a large family of membrane receptors distributed over diverse organisms, such as bacteria, fungi, plants and all metazoans. However, the presence of serpentine receptors in protozoan parasites is largely unknown so far.
Externí odkaz:
https://doaj.org/article/fa095ccf5c40465c92b8727b36fe972b
Autor:
Pollyana M.S. Melo, Marcos L. Gazarini, Adriana B Thurler, Mauro F Azevedo, Jorge González-Bacerio, Sarah El Chamy Maluf, Adriana K. Carmona, Alexandre Budu, Carolina Caldas Hoff, Maday Alonso del Rivero
Publikováno v:
Pathogens
Volume 10
Issue 11
Pathogens, Vol 10, Iss 1452, p 1452 (2021)
Volume 10
Issue 11
Pathogens, Vol 10, Iss 1452, p 1452 (2021)
Plasmodium falciparum, the most virulent of the human malaria parasite, is responsible for high mortality rates worldwide. We studied the M1 alanyl-aminopeptidase of this protozoan (PfA-M1), which is involved in the final stages of hemoglobin cleavag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33aadb9879f3ec998c8b3dc3770050d5
https://doi.org/10.3390/pathogens10111452
https://doi.org/10.3390/pathogens10111452
Autor:
Claudia Banchio, Ignasi Bofill Verdaguer, Exequiel O. J. Porta, Guillermo R. Labadie, Alejandro M. Katzin, Consuelo Perez, Mauro F Azevedo
Publikováno v:
Medchemcomm
Malaria is a serious tropical disease that kills thousands of people every year, mainly in Africa, due to Plasmodium falciparum infections. Salirasib is a promising cancer drug candidate that interferes with the post-translational modification of Ras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f51e969236dcc4b9c7bbdc0bd44500e
https://pubmed.ncbi.nlm.nih.gov/31803400
https://pubmed.ncbi.nlm.nih.gov/31803400
Publikováno v:
Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 10 (2018)
Memórias do Instituto Oswaldo Cruz, Volume: 113, Issue: 10, Article number: e180174, Published: 13 AUG 2018
Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 10 (2018)
Memórias do Instituto Oswaldo Cruz, Volume: 113, Issue: 10, Article number: e180174, Published: 13 AUG 2018
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e785027fe6cba0746106c4e8277630e
https://doi.org/10.1590/0074-02760180174
https://doi.org/10.1590/0074-02760180174