Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mauro D. Locati"'
Autor:
Luan Nguyen, Myrthe Jager, Ruby Lieshout, Petra E. de Ruiter, Mauro D. Locati, Nicolle Besselink, Bastiaan van der Roest, Roel Janssen, Sander Boymans, Jeroen de Jonge, Jan N. M. IJzermans, Michail Doukas, Monique M. A. Verstegen, Ruben van Boxtel, Luc J. W. van der Laan, Edwin Cuppen, Ewart Kuijk
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Nguyen et al. used liver organoid cultures to identify all somatic mutations in individual stem cells from patients with common liver diseases that confer risk of cancer. The authors report that, compared to healthy liver, these precancerous liver di
Externí odkaz:
https://doaj.org/article/96839cce3bec43feb376e5547a803268
Autor:
Ewart Kuijk, Myrthe Jager, Bastiaan van der Roest, Mauro D. Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Genetic changes acquired during in vitro culture pose a challenge to application of stem cells. Here the authors use whole genome sequencing to show that cultured human adult and pluripotent stem cells have a high mutational load caused by oxidative
Externí odkaz:
https://doaj.org/article/1f6a475491464666a79c0e3f7512c41e
Autor:
Ewart Kuijk, Myrthe Jager, Bastiaan van der Roest, Mauro D. Locati, Arne Van Hoeck, Jerome Korzelius, Roel Janssen, Nicolle Besselink, Sander Boymans, Ruben van Boxtel, Edwin Cuppen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/ed8e577e7e504584b8fd4c8ae2098f00
Autor:
Ruben van Boxtel, Nicolle Besselink, Mauro D. Locati, Sander Boymans, Ruby Lieshout, Roel Janssen, Luan Nguyen, Michail Doukas, Myrthe Jager, Ewart W. Kuijk, Edwin Cuppen, Luc J. W. van der Laan, Jeroen de Jonge, Bastiaan van der Roest, Jan N. M. IJzermans, Petra E. de Ruiter, Monique M A Verstegen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology, 4(1):1301. Springer Nature
Communications Biology
Communications Biology, 4(1):1301. Springer Nature
Communications Biology
Inflammatory liver disease increases the risk of developing primary liver cancer. The mechanism through which liver disease induces tumorigenesis remains unclear, but is thought to occur via increased mutagenesis. Here, we performed whole-genome sequ
Autor:
Arne Van Hoeck, Ruben van Boxtel, Sander Boymans, Roel Janssen, Mauro D. Locati, Jerome Korzelius, Edwin Cuppen, Nicolle Besselink, Myrthe Jager, Ewart W. Kuijk, Bastiaan van der Roest
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Genetic changes acquired during in vitro culture pose a risk for the successful application of stem cells in regenerative medicine. To assess the genetic risks induced by culturing, we determined all mutations in individual human stem cells by whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f115a6e2847bdbd69309515e0713bfa
https://kar.kent.ac.uk/81480/1/s41467-020-16323-4.pdf
https://kar.kent.ac.uk/81480/1/s41467-020-16323-4.pdf
Autor:
Ruben van Boxtel, Jeroen de Jonge, Michael Doukas, Nicolle Besselink, Luc J. W. van der Laan, Myrthe Jager, Roel Janssen, Jan N. M. IJzermans, Mauro D. Locati, Sander Boymans, Edwin Cuppen, Ruby Lieshout, Ewart W. Kuijk, Monique M A Verstegen, Bastiaan van der Roest
Excessive alcohol consumption increases the risk of developing liver cancer, but the mechanism through which alcohol drives carcinogenesis is as yet unknown. Here, we determined the mutational consequences of chronic alcohol use on the genome of huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa08f5b4d1fc1a816f2cc07580dc07d6
https://doi.org/10.1101/698894
https://doi.org/10.1101/698894
Autor:
Arne Van Hoeck, Edwin Cuppen, Myrthe Jager, Roel Janssen, Nicolle Besselink, Bastiaan van der Roest, Ewart W. Kuijk, Jerome Korzelius, Mauro D. Locati, Ruben van Boxtel, Sander Boymans
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications
Nature Communications
Genetic changes acquired during in vitro culture pose a risk for the successful application of stem cells in regenerative medicine. To assess the genetic risks induced by culturing, we determined all mutations in individual human stem cells by whole
Autor:
Mauro D. Locati, Ruben van Boxtel, Myrthe Jager, Sander Boymans, Bastiaan van der Roest, Roel Janssen, Edwin Cuppen, Arne Van Hoeck, Nicolle Besselink, Jerome Korzelius, Ewart W. Kuijk
Publikováno v:
BioRxiv (pre-print server)
Genetic changes acquired during in vitro culture pose a potential risk for the successful application of stem cells in regenerative medicine. To assess mutation accumulation risks induced by culturing, we determined genetic aberrations in individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d741b3bf19f3f0d1316f5a94b12fc8
Autor:
Martijs J. Jonker, Mauro D. Locati, Rob J. Dekker, Timo M. Breit, Ulrike Nehrdich, Herman P. Spaink, Johanna F.B. Pagano, Marina van Olst, Han Rauwerda, Selina van Leeuwen, Wim A. Ensink, Farah Abdullah
Publikováno v:
Genome, 61(5), 371-378. National Research Council of Canada
Genome, 61(5), 371-378
Genome
Genome, 61(5), 371-378
Genome
rRNAs are non-coding RNAs present in all prokaryotes and eukaryotes. In eukaryotes there are four rRNAs: 18S, 5.8S, 28S, originating from a common precursor (45S), and 5S. We have recently discovered the existence of two distinct developmental types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8483b9e1fa69a3de8f1210ea480c6d40
https://dare.uva.nl/personal/pure/en/publications/identifying-small-rnas-derived-from-maternal-and-somatictype-rrnas-in-zebrafish-development(e52cdacc-84c5-4b23-9e10-c23ed1f3beec).html
https://dare.uva.nl/personal/pure/en/publications/identifying-small-rnas-derived-from-maternal-and-somatictype-rrnas-in-zebrafish-development(e52cdacc-84c5-4b23-9e10-c23ed1f3beec).html
Autor:
Selina van Leeuwen, Mauro D. Locati, Martijs J. Jonker, Johanna F.B. Pagano, Marina van Olst, Wim A. Ensink, Rob J. Dekker, Ulrike Nehrdich, Timo M. Breit, Geneviève Girard, Herman P. Spaink, Han Rauwerda
Publikováno v:
RNA, 23(8), 1188-1199. Cold Spring Harbor Laboratory Press
RNA, 23, 1188-1199
RNA
RNA, 23, 1188-1199
RNA
There is mounting evidence that the ribosome is not a static translation machinery, but a cell-specific, adaptive system. Ribosomal variations have mostly been studied at the protein level, even though the essential transcriptional functions are prim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed372d259b2bcd2f144ad2f02972ed9
https://dare.uva.nl/personal/pure/en/publications/expression-of-distinct-maternal-and-somatic-58s-18s-and-28s-rrna-types-during-zebrafish-development(da86a2e4-5d61-4d58-862e-f8adc527373f).html
https://dare.uva.nl/personal/pure/en/publications/expression-of-distinct-maternal-and-somatic-58s-18s-and-28s-rrna-types-during-zebrafish-development(da86a2e4-5d61-4d58-862e-f8adc527373f).html