Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mauro Angiolini"'
Autor:
Mauro Angiolini
Publikováno v:
Structural Biology in Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c0abc80b02cdd6f14539adc412dd49e
https://doi.org/10.1002/9781118681121.ch16
https://doi.org/10.1002/9781118681121.ch16
Autor:
Christian Orrenius, Arturo Galvani, Peter K. Jackson, Paola Magnaghi, Mauro Angiolini, Steven Magnuson, Thomas O'Brien, Liviana Cozzi, Daniele Donati, Nuvoloni Stefano, Alessandra Badari, Elena Casale, Simona Rizzi, Nilla Avanzi, Laura Riceputi, Federico Riccardi Sirtori, Roberto D'Alessio, Yichin Liu, Alessandra Cirla, Silvia Cauteruccio, Beatrice Trucchi, Antonella Isacchi, Paolo Polucci, Daniela Asa, J.A. Bertrand, Malgesini Ms Beatrice
Publikováno v:
Journal of Medicinal Chemistry. 56:437-450
Valosine containing protein (VCP), also known as p97, is a member of AAA ATPase family that is involved in several biological processes and plays a central role in the ubiquitin-mediated degradation of misfolded proteins. VCP is an ubiquitously expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fc6656434a58389f909d5ad7802fe9
https://doi.org/10.1021/jm3013213
https://doi.org/10.1021/jm3013213
Autor:
Adam Hughes, Jonathan B. Baell, Paolo Pevarello, Orn Almarsson, Andrew Ingham, Robert D. Sindelar, Mauro Angiolini, Giuseppe Giardina
Publikováno v:
Pharmaceutical Patent Analyst. 1:129-135
Patents are clearly one of the main drivers of innovation in pharmaceutical and medical R&D. It is increasingly important for researchers at the sharp end to be familiar with the ins and outs of the patenting process. In this feature a panel of exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8346d92ff1e4a484abda2b71332b883
https://doi.org/10.4155/ppa.12.15
https://doi.org/10.4155/ppa.12.15
Publikováno v:
Tetrahedron Letters. 46:8749-8752
A novel solid-phase method for the synthesis of 4-methyl-pyrido[2,3- d ]pyrimidin-7-one compounds with two diversity points is described. The polymer supported methylsulfonyl derivatives A 3 , achieved by coupling compound G with different resin-boun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dbeb2fc48e2ea21f99412beb35d82f9
https://doi.org/10.1016/j.tetlet.2005.10.030
https://doi.org/10.1016/j.tetlet.2005.10.030
Autor:
Marco Beretta, Gianluca Papeo, Stephen Hanessian, Kamal Fettis, Mauro Angiolini, Alexander Munro
Publikováno v:
Scopus-Elsevier
Alkylation of the monoenolate of N-Boc-l-pyroglutamic acid methyl ester with a variety of benzylic halides and their homologues gave the corresponding anti-C-4-alkylated products as major products. Formation of the N-Boc-iminium ion and Friedel-Craft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cfbb8c45a22602e8986441b9ebda6c
https://doi.org/10.1021/jo0301447
https://doi.org/10.1021/jo0301447
Publikováno v:
Tetrahedron Letters. 44:519-522
In this Letter a fast and useful parallel synthesis approach to 4-amino-2,6-dialkylamino-pyridines is described starting from commercially available 2,6-difluoro-3,5-dichloro-pyridine. Both symmetrical and unsymmetrical derivatives have been synthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2bf191b29f49e4be2a400dfd2840bd
https://doi.org/10.1016/s0040-4039(02)02585-6
https://doi.org/10.1016/s0040-4039(02)02585-6
Conformationally Stable and Constrained Macrocarbocyclic Pseudopeptide Mimics ofβ-Hairpin Structures
Autor:
Stephen Hanessian, Mauro Angiolini
Publikováno v:
Chemistry - A European Journal. 8:111-117
Subjecting a D-Pro-L-Pro template harboring N- and C-terminal omega-alkenyl amino acids to a ring-closure metathesis reaction afforded the corresponding macrocyclic alkenes. A cis-alkene analogue crystallized with one molecule each of water and chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b8d54c86739c2d75d91a165d890b2aa
https://doi.org/10.1002/1521-3765(20020104)8:1<111::aid-chem111>3.0.co
https://doi.org/10.1002/1521-3765(20020104)8:1<111::aid-chem111>3.0.co
Autor:
Mauro Angiolini, Carlo Scolastico, Leonardo Manzoni, Edoardo Cesarotti, L Crippa, Laura Belvisi, S. Araneo, Anna Checchia
Publikováno v:
ResearcherID
In an effort to design dipeptide structural mimics of protein and peptide reverse-turns, a series of 5,5-, 6,5-, and 7,5-fused 2-oxo-1-azabicycloalkane amino acids has been synthesized. A new and convenient synthetic route utilizing a Horner−Emmons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6bdd262760cdab9864df832f1d4d21
https://doi.org/10.1002/1099-0690(200007)2000:14<2571::aid-ejoc2571>3.0.co
https://doi.org/10.1002/1099-0690(200007)2000:14<2571::aid-ejoc2571>3.0.co
Publikováno v:
Tetrahedron Letters. 50:5156-5158
In this Letter the synthetic pathway adopted for the preparation of a new functionalized tricyclic scaffold containing the 7-azaindole moiety is presented. An intramolecular palladium-mediated reaction is described as the crucial step for a condensed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa5fef12944e26baa6a34b0486baacaf
https://doi.org/10.1016/j.tetlet.2009.06.126
https://doi.org/10.1016/j.tetlet.2009.06.126
Autor:
Mauro Angiolini, Carlo Scolastico, Aldo Salimbeni, Nunzio Sciammetta, Laura Belvisi, Davide Poma
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:2013-2027
Extensive molecular modelling studies, including conformational analysis and the comparison of molecular electrostatic potential distributions, wee used to evaluate structural parameters of new antagonists containing acyclic replacements of the N = C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6532e89f10c35d76dfdb079d282ee332
https://doi.org/10.1016/s0968-0896(98)00160-6
https://doi.org/10.1016/s0968-0896(98)00160-6