Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mauro Gobbini"'
Autor:
Giuseppe Marazzi, Giulio Carzana, Silvia Armaroli, Giuseppe Giacalone, Zappavigna Maria Pia, Patrizia Ferrari, Simona Sputore, Alessandra Benicchio, Alberto Cerri, Banfi Leonardo, Mauro Gobbini, Barbara Moro, R. Micheletti, Marco Torri
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:4275-4299
We report the synthesis and biological properties of novel analogues of Istaroxime acting as positive inotropic compounds through the inhibition of the Na(+),K(+)-ATPase. We explored the chemical space around the position 6 of the steroidal scaffold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74eee182ce07b88913258785b0d8658
https://doi.org/10.1016/j.bmc.2010.04.095
https://doi.org/10.1016/j.bmc.2010.04.095
Autor:
Alessandra Benicchio, Banfi Leonardo, Giulio Carzana, Marco Pozzi, Giorgio Fedrizzi, Patrizia Ferrari, Giuseppe Marazzi, Barbara Moro, Mauro Gobbini, Michele Giubileo, R. Micheletti, Silvia Armaroli, Giuseppe Giacalone, Alberto Cerri, Piero Enrico Scotti, Marco Torri
Publikováno v:
Journal of Medicinal Chemistry. 51:4601-4608
We report the synthesis and biological properties of novel inhibitors of the Na(+),K(+)-ATPase as positive inotropic compounds. Following our previously described model from which Istaroxime was generated, the 5alpha,14alpha-androstane skeleton was u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c6708c430a42be68b2fa9e3d26d19f
https://doi.org/10.1021/jm800257s
https://doi.org/10.1021/jm800257s
Autor:
Paolo Barassi, Marco Santagostino, Mauro Gobbini, Giorgio Fedrizzi, Marco Torri, Antonio Schiavone, Piero Melloni, Alberto Cerri, De Munari S
Publikováno v:
Journal of Medicinal Chemistry. 44:3821-3830
The synthesis and binding affinities to the digitalis Na(+),K(+)-ATPase receptor of a series of 3 beta,14 beta-dihydroxy-5 beta-androstane and 3 beta-hydroxy-14-oxoseco-D-5 beta-androstane derivatives bearing a 17 alpha-(aminoalkoxy)imino chain are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4db64296162e95df3fe1d2feccd0b3
https://doi.org/10.1021/jm0109208
https://doi.org/10.1021/jm0109208
Autor:
Gloria Padoani, Luisa Quadri, Zappavigna Maria Pia, Loredana Valentino, Piero Melloni, Mauro Gobbini, Giuseppe Marazzi
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:1889-1894
The four stereoisomers of the 2-hydroxy derivatives of digitoxigenin and 3-epidigitoxigenin have been synthesized, their structures established by NMR, and their binding affinity for the digitalis receptor on Na + , K + -ATPase evaluated. These deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06a56a99a3d949ca054a3bd18cdbf866
https://doi.org/10.1016/s0968-0896(98)00119-9
https://doi.org/10.1016/s0968-0896(98)00119-9
Publikováno v:
Molecules
Volume 3
Issue 1
Pages 20-25
Molecules, Vol 3, Iss 1, Pp 20-25 (1998)
Volume 3
Issue 1
Pages 20-25
Molecules, Vol 3, Iss 1, Pp 20-25 (1998)
M. Gobbini,** N. Almirante, A. Cerri, G. Padoani and P. MelloniPrassis Istituto di Ricerche Sigma-Tau, Via Forlanini, 3, 20019 Settimo Milanese (MI), Italy. Tel +39 2 33500388, Fax +392 33500408, Email: MC3405@mclink.itReceived: 11 November 1997 / Ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612bc52b2754a4ac805111cffaf4bc6e
https://doi.org/10.3390/30100020
https://doi.org/10.3390/30100020
Autor:
Patrizia Ferrari, Luisa Quadri, Giorgio Fedrizzi, Mauro Gobbini, P. Melloni, Alberto Cerri, Giuseppe Bianchi, Marco Torri, Simona Sputore
Publikováno v:
Journal of Medicinal Chemistry. 40:1561-1564
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87ee19e2d8d865532539254b80627116
https://doi.org/10.1021/jm970162e
https://doi.org/10.1021/jm970162e
Autor:
Mauro Gobbini, Marco Torri
Publikováno v:
Synthetic Communications. 27:1115-1122
An efficient and practical synthesis of 3β,14β-dihydroxy-5β-androstane-17β-carboxaldehyde is described. The key oxidative cleavage of the unsaturated lactone of 3-acetyldigitoxigenin 1 utilises RuO4 as catalytic and NaIO4 as stoichiometric oxidan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::409edd34ed3c9ff0d530b73477167305
https://doi.org/10.1080/00397919708003058
https://doi.org/10.1080/00397919708003058
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:469-472
The synthesis and the binding affinities to the digitalis receptor on the Na+,K+-ATPase of a series of 3β-(aminoalkylthio) digitalis derivatives are described. In most cases these derivatives showed a higher binding affinity than that of the corresp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20699fe78c446454244e5e10ac189854
https://doi.org/10.1016/s0960-894x(97)00039-5
https://doi.org/10.1016/s0960-894x(97)00039-5
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4a0418035a49d3228ef6e7cf29d249e
https://doi.org/10.1002/chin.199724197
https://doi.org/10.1002/chin.199724197
Autor:
Marco Torri, Mauro Gobbini
Publikováno v:
ChemInform. 28
An efficient and practical synthesis of 3β,14β-dihydroxy-5β-androstane-17β-carboxaldehyde is described. The key oxidative cleavage of the unsaturated lactone of 3-acetyldigitoxigenin 1 utilises RuO4 as catalytic and NaIO4 as stoichiometric oxidan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c841acdc20141a066f03268e9d50981
https://doi.org/10.1002/chin.199727201
https://doi.org/10.1002/chin.199727201