Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Maurizio Giustetto"'
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Autor:
Clara Alice Musi, Anna Maria Castaldo, Anna Elisa Valsecchi, Sara Cimini, Noemi Morello, Riccardo Pizzo, Alessandra Renieri, Ilaria Meloni, Maurizio Bonati, Maurizio Giustetto, Tiziana Borsello
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-20 (2021)
Abstract Background Rett syndrome (RTT) is a monogenic X-linked neurodevelopmental disorder characterized by loss-of-function mutations in the MECP2 gene, which lead to structural and functional changes in synapse communication, and impairments of ne
Externí odkaz:
https://doaj.org/article/b64d30a035a640dca4549373d8eafe05
Autor:
Carla Liaci, Mattia Camera, Valentina Zamboni, Gabriella Sarò, Alessandra Ammoni, Elena Parmigiani, Luisa Ponzoni, Enis Hidisoglu, Giuseppe Chiantia, Andrea Marcantoni, Maurizio Giustetto, Giulia Tomagra, Valentina Carabelli, Federico Torelli, Mariaelvina Sala, Yuchio Yanagawa, Kunihiko Obata, Emilio Hirsch, Giorgio R. Merlo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
GTPases of the Rho family are components of signaling pathways linking extracellular signals to the control of cytoskeleton dynamics. Among these, RAC1 plays key roles during brain development, ranging from neuronal migration to neuritogenesis, synap
Externí odkaz:
https://doaj.org/article/7f6ab99d484c4bf587fe50b38a8dbf72
Autor:
Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali, Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani
Publikováno v:
Neurobiology of Disease, Vol 153, Iss , Pp 105304- (2021)
CDKL5 (cyclin-dependent kinase-like 5) deficiency disorder (CDD) is a severe neurodevelopmental encephalopathy characterized by early-onset epilepsy and intellectual disability. Studies in mouse models have linked CDKL5 deficiency to defects in neuro
Externí odkaz:
https://doaj.org/article/3f1b1ea45f95440d9995c30bfaff2f22
Autor:
Yassine Ait bali, Nour-eddine Kaikai, Saadia Ba-M’hamed, Marco Sassoè-Pognetto, Maurizio Giustetto, Mohamed Bennis
Publikováno v:
Toxics, Vol 10, Iss 5, p 226 (2022)
Growing evidence demonstrates that serotonin (5-HT) depletion increases activity in the amygdala and medial prefrontal cortex (mPFC), ultimately leading to anxiety behavior. Previously, we showed that glyphosate-based herbicides (GBHs) increased anxi
Externí odkaz:
https://doaj.org/article/b2cb163216754aaf93799d88641755a0
Autor:
Noemi Morello, Ornella Plicato, Maria Antonietta Piludu, Laura Poddighe, Maria Pina Serra, Marina Quartu, Maria Giuseppa Corda, Osvaldo Giorgi, Maurizio Giustetto
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170093 (2017)
Stressful events evoke molecular adaptations of neural circuits through chromatin remodeling and regulation of gene expression. However, the identity of the molecular pathways activated by stress in experimental models of depression is not fully unde
Externí odkaz:
https://doaj.org/article/9344d61db5b34e1093fece6807421a3c
Autor:
Ana I Arroyo, Paola G Camoletto, Laura Morando, Marco Sassoe‐Pognetto, Maurizio Giustetto, Paul P Van Veldhoven, Edward H Schuchman, Maria D Ledesma
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 3, Pp 398-413 (2014)
Abstract Understanding the role of lipids in synapses and the aberrant molecular mechanisms causing the cognitive deficits that characterize most lipidosis is necessary to develop therapies for these diseases. Here we describe sphingomyelin (SM) as a
Externí odkaz:
https://doaj.org/article/d9cfd6c1aba447d89b9dc036289ee51f
Autor:
Riccardo Pizzo, Enrico Castroflorio, Antonia Gurgone, Elena Amendola, Cornelius Gross, Marco Sassoè-Pognetto, Maurizio Giustetto
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 10 (2016)
CDKL5 (cyclin-dependent kinase-like 5) mutations are found in severe neurodevelopmental disorders, including the Hanefeld variant of Rett syndrome (CDKL5 disorder). CDKL5 loss-of-function murine models recapitulate pathological signs of the human dis
Externí odkaz:
https://doaj.org/article/c77dfc00ce094bdcb03eca6e0399d9a7
Autor:
David M. Katz, Joanne E. Berger-Sweeney, James H. Eubanks, Monica J. Justice, Jeffrey L. Neul, Lucas Pozzo-Miller, Mary E. Blue, Diana Christian, Jacqueline N. Crawley, Maurizio Giustetto, Jacky Guy, C. James Howell, Miriam Kron, Sacha B. Nelson, Rodney C. Samaco, Laura R. Schaevitz, Coryse St. Hillaire-Clarke, Juan L. Young, Huda Y. Zoghbi, Laura A. Mamounas
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 6, Pp 733-745 (2012)
In September of 2011, the National Institute of Neurological Disorders and Stroke (NINDS), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the International Rett Syndrome Foundation (IRSF) and the Rett Syn
Externí odkaz:
https://doaj.org/article/e47f996a0ef64ccab86e468a2e1e40e3
Autor:
Elena Amendola, Yang Zhan, Camilla Mattucci, Enrico Castroflorio, Eleonora Calcagno, Claudia Fuchs, Giuseppina Lonetti, Davide Silingardi, Alexei L Vyssotski, Dominika Farley, Elisabetta Ciani, Tommaso Pizzorusso, Maurizio Giustetto, Cornelius T Gross
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e91613 (2014)
Mutations in cyclin-dependent kinase-like 5 (CDKL5) cause early-onset epileptic encephalopathy, a neurodevelopmental disorder with similarities to Rett Syndrome. Here we describe the physiological, molecular, and behavioral phenotyping of a Cdkl5 con
Externí odkaz:
https://doaj.org/article/d45b19ecb62749ff9f027ee1b74272dc