Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Maurizio Federico"'
Autor:
Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti, Maurizio Federico
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Induction of effective immunity in the lungs should be a requisite for any vaccine designed to control the severe pathogenic effects generated by respiratory infectious agents. We recently provided evidence that the generation of endogenous
Externí odkaz:
https://doaj.org/article/eb081687f21442b483c9c02222fd9bdc
Autor:
Maurizio Federico
Publikováno v:
Vaccines, Vol 11, Iss 12, p 1847 (2023)
The emergence of tumors associated with defects in immune surveillance often involve the impairment of key functions of T lymphocytes. Therefore, several anticancer immunotherapies have focused on the induction/strengthening of the tumor-specific act
Externí odkaz:
https://doaj.org/article/8f2f0e66c4db41de9f2db38308d273ed
Autor:
Flavia Ferrantelli, Francesco Manfredi, Chiara Chiozzini, Patrizia Leone, Katherina Pugliese, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Mauro Valeri, Andrea Cara, Zuleika Michelini, Mauro Andreotti, Maurizio Federico
Publikováno v:
Vaccines, Vol 11, Iss 9, p 1433 (2023)
Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 enters the host by infecting nasal ciliated cells. Then, the virus can spread towards the oropharyngeal cavity and the pulmonary tissues. The antiviral adaptive immunity is promptly induced i
Externí odkaz:
https://doaj.org/article/7d872f04b65d4f41b4649aa68b4a65b0
Autor:
Maurizio Federico
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
Several vaccine strategies are now available to fight the current SARS-CoV-2 pandemic. Those based on the administration of lipid-complexed messenger(m)RNA molecules represent the last frontiers in terms of technology innovation. mRNA molecules codin
Externí odkaz:
https://doaj.org/article/d49899193bd04a09851b2addc1a38a3e
Autor:
Alessandro Ascione, Claudia Arenaccio, Alessandra Mallano, Michela Flego, Mara Gellini, Mauro Andreotti, Craig Fenwick, Giuseppe Pantaleo, Stefano Vella, Maurizio Federico
Publikováno v:
BMC Biotechnology, Vol 19, Iss 1, Pp 1-15 (2019)
Abstract Background Lymphocyte-activation gene (LAG)3 is a 498 aa transmembrane type I protein acting as an immune inhibitory receptor. It is expressed on activated lymphocytes, natural killer cells and plasmacytoid dendritic cells. In activated lymp
Externí odkaz:
https://doaj.org/article/ea888644d8434b0da4411f120e225ee5
Autor:
Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Massimo Sanchez, Maurizio Federico
Publikováno v:
Vaccines, Vol 10, Iss 7, p 1060 (2022)
We propose an innovative anti-SARS-CoV-2 immune strategy based on extracellular vesicles (EVs) inducing an anti-SARS-CoV-2 N CD8+ T cytotoxic lymphocyte (CTL) immune response. We previously reported that the SARS-CoV-2 N protein can be uploaded at hi
Externí odkaz:
https://doaj.org/article/27a49e3cb82f43e88afcf14b2be30919
Autor:
Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Patrizia Leone, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Massimo Sanchez, Andrea Cara, Zuleika Michelini, Maurizio Federico
Publikováno v:
Viruses, Vol 14, Iss 2, p 329 (2022)
SARS-CoV-2-specific CD8+ T cell immunity is expected to counteract viral variants in both efficient and durable ways. We recently described a way to induce a potent SARS-CoV-2 CD8+ T immune response through the generation of engineered extracellular
Externí odkaz:
https://doaj.org/article/bd34405a3e554f2eb1d238514b8fc0c3
Autor:
Maurizio Federico
Publikováno v:
Vaccines, Vol 9, Iss 8, p 922 (2021)
The current battle against Severe Acute Respiratory Syndrome (SARS)-Coronavirus-2 benefits from the worldwide distribution of different vaccine formulations. All anti-SARS-CoV-2 vaccines in use are conceived to induce anti-Spike neutralizing antibodi
Externí odkaz:
https://doaj.org/article/3e79fc6b50b44ba4813ca6940d57328a
Autor:
Chiara Chiozzini, Francesco Manfredi, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Eleonora Olivetta, Maurizio Federico
Publikováno v:
Vaccines, Vol 9, Iss 4, p 373 (2021)
Intramuscular injection of DNA vectors expressing the extracellular vesicle (EV)-anchoring protein Nefmut fused at its C-terminus to viral and tumor antigens elicit a potent, effective, and anti-tolerogenic CD8+ T cell immunity against the heterologo
Externí odkaz:
https://doaj.org/article/863f59beec024b64840311d45176b793
Autor:
Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Andrea Giovannelli, Patrizia Leone, Maurizio Federico
Publikováno v:
Vaccines, Vol 9, Iss 3, p 240 (2021)
Most advanced vaccines against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 are designed to induce antibodies against spike (S) protein. Differently, we developed an original strategy to induce CD8+ T cytotoxic lymphocyte (CTL) immunity
Externí odkaz:
https://doaj.org/article/72125878bdb04ff2b5ec0ad58334154f