Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Maurizio Del Poeta"'
Autor:
Natalia Kronbauer Oliveira, Kyungyoon Yoo, Somanon Bhattacharya, Rina Gambhir, Nigina Kirgizbaeva, Pilar Arcones García, Ignacio Pompa Prados, Caroline Mota Fernandes, Maurizio Del Poeta, Bettina C. Fries
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Cryptococcus neoformans (Cn) is an opportunistic yeast that causes meningoencephalitis in immunocompromised individuals. Calorie restriction (CR) prolongs Cn replicative lifespan (RLS) and mimics low-glucose environments in which Cn resides
Externí odkaz:
https://doaj.org/article/78c0f3c0c09d423cb4a64e7faae09013
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Invasive fungal infections (IFIs) caused by pathogenic fungi pose a significant public health concern, particularly for immunocompromised individuals. Mortality rates for IFIs remain high, and currently available treatment options are limite
Externí odkaz:
https://doaj.org/article/b6ec80574dae41ec9ff6dccd2d288a8b
Autor:
Xin Zhou, Audrey Hilk, Norma V Solis, Nivea Pereira De Sa, Bode M Hogan, Tessa A Bierbaum, Maurizio Del Poeta, Scott G Filler, Laura S Burrack, Anna Selmecki
Publikováno v:
PLoS Pathogens, Vol 20, Iss 7, p e1012389 (2024)
Ergosterol is essential for fungal cell membrane integrity and growth, and numerous antifungal drugs target ergosterol. Inactivation or modification of ergosterol biosynthetic genes can lead to changes in antifungal drug susceptibility, filamentation
Externí odkaz:
https://doaj.org/article/74e7071a7fd741f9867c94874908f19c
Autor:
Isabella Dib Ferreira Gremião, Gabriela Reis Pereira-Oliveira, Sandro Antonio Pereira, Maria Lopes Corrêa, Luana Pereira Borba-Santos, Alessandra Lifsitch Viçosa, Ashna Garg, Krupanandan Haranahalli, Deveney Dasilva, Nivea Pereira de Sa, Gabriel S. Matos, Vanessa Silva, Cristina Lazzarini, Caroline Mota Fernandes, Kildare Miranda, Jhon Jhamilton Artunduaga Bonilla, Anna Letícia Nunes, Leonardo Nimrichter, Iwao Ojima, John Mallamo, John B. McCarthy, Maurizio Del Poeta
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 6 (2024)
ABSTRACT Acylhydrazone (AH) derivatives represent a novel category of anti-fungal medications that exhibit potent activity against Sporothrix sp., both in vitro and in a murine model of sporotrichosis. In this study, we demonstrated the anti-fungal e
Externí odkaz:
https://doaj.org/article/9a2aba0c9d7847cbb62ff4a8532b18f8
Autor:
Liping Xiong, Nivea Pereira De Sa, Robert Zarnowski, Manning Y Huang, Caroline Mota Fernandes, Frederick Lanni, David R Andes, Maurizio Del Poeta, Aaron P Mitchell
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012225 (2024)
Biofilm formation by the fungal pathogen Candida albicans is the basis for its ability to infect medical devices. The metabolic gene ERG251 has been identified as a target of biofilm transcriptional regulator Efg1, and here we report that ERG251 is r
Externí odkaz:
https://doaj.org/article/29da080bdb6443be8269d4051846cc2b
Autor:
Xue-Ming Zhu, Lin Li, Jian-Dong Bao, Jiao-Yu Wang, Asen Daskalov, Xiao-Hong Liu, Maurizio Del Poeta, Fu-Cheng Lin
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011733 (2023)
Sphingolipids are critically significant in a range of biological processes in animals, plants, and fungi. In mammalian cells, they serve as vital components of the plasma membrane (PM) in maintaining its structure, tension, and fluidity. They also p
Externí odkaz:
https://doaj.org/article/f9d347361a8747ff846aca0627bce95b
Autor:
João Henrique Tadini Marilhano Fabri, Marina Campos Rocha, Caroline Mota Fernandes, Jonatas Erick Maimoni Campanella, Anderson Ferreira da Cunha, Maurizio Del Poeta, Iran Malavazi
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Thermotolerance is a remarkable virulence attribute of Aspergillus fumigatus, but the consequences of heat shock (HS) to the cell membrane of this fungus are unknown, although this structure is one of the first to detect changes in ambient t
Externí odkaz:
https://doaj.org/article/037e0139b7a542278ca22c4f029dc2e4
Autor:
Nicole M. Revie, Kali R. Iyer, Michelle E. Maxson, Jiabao Zhang, Su Yan, Caroline M. Fernandes, Kirsten J. Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S. Shapiro, David R. Andes, Gerard D. Wright, Justin R. Nodwell, Maurizio Del Poeta, Martin D. Burke, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
There is an urgent need for novel strategies to combat life-threatening fungal infections. Here, Revie et al. identify a compound that induces alterations in fungal membranes, synergizes with azole antifungals against the pathogen Candida albicans, a
Externí odkaz:
https://doaj.org/article/8bca44075efb4f07a12ae3b736c09d4d
Autor:
Nivea Pereira de Sa, Kalani Jayanetti, Dominick Rendina, Timothy Clement, Veronica Soares Brauer, Caroline Mota Fernandes, Iwao Ojima, Michael V. Airola, Maurizio Del Poeta
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT Invasive fungal infections are a leading cause of death in immunocompromised patients. Current therapies have several limitations, and innovative antifungal agents are critically needed. Previously, we identified the fungus-specific enzyme s
Externí odkaz:
https://doaj.org/article/10a62aeb5767483fa4514f5d67e00b54
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011115 (2023)
Vaccines are one of the most effective public health tools to prevent and manage infectious diseases. Since the first clinical use of vaccines in the late 18th century, many vaccines have been successfully developed to combat bacterial and viral infe
Externí odkaz:
https://doaj.org/article/1c081750fc734c8c9524d70f2062967d