Zobrazeno 1 - 10 of 158 pro vyhledávání: '"Maurizio Anzini"'
1
Akademický článek
Enantioseparation of novel anti-inflammatory chiral sulfoxides with two cellulose dichlorophenylcarbamate-based chiral stationary phases and polar-organic mobile phase(s)
Autor: Ina Varfaj, Alessandro Di Michele, Federica Ianni, Mario Saletti, Maurizio Anzini, Carolina Barola, Bazan Chankvetadze, Roccaldo Sardella, Andrea Carotti
Publikováno v: Journal of Chromatography Open, Vol 1, Iss , Pp 100022- (2021)
Chiral sulfoxides represent a class of substances of great importance in many fields, including medicinal chemistry dealing with the synthesis of novel cyclooxygenase-2 (COX-2) inhibiting/NO donors. In the present study, two nitrooxyethyl sulfoxides
Externí odkaz: https://doaj.org/article/325b0f312c5e42ba8379255c91bb1c39
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4
Akademický článek
Synthesis of trifluoromethyl-substituted pyrazolo[4,3-c]pyridines – sequential versus multicomponent reaction approach
Autor: Barbara Palka, Angela Di Capua, Maurizio Anzini, Gyté Vilkauskaité, Algirdas Šačkus, Wolfgang Holzer
Publikováno v: Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1759-1764 (2014)
A straightforward synthesis of 6-substituted 1-phenyl-3-trifluoromethyl-1H-pyrazolo[4,3-c]pyridines and the corresponding 5-oxides is presented. Hence, microwave-assisted treatment of 5-chloro-1-phenyl-3-trifluoromethylpyrazole-4-carbaldehyde with va
Externí odkaz: https://doaj.org/article/672aca6d950346e9a68226d357dce681
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6
Akademický článek
In Vitro Effects of VA441, a New Selective Cyclooxygenase-2 Inhibitor, on Human Osteoarthritic Chondrocytes exposed to IL-1β
Autor: Antonella Fioravanti, Laura Tinti, Nicola Antonio Pascarelli, Angela Di Capua, Antonello Lamboglia, Andrea Cappelli, Mariangela Biava, Antonio Giordani, Silvia Niccolini, Mauro Galeazzi, Maurizio Anzini
Publikováno v: Journal of Pharmacological Sciences, Vol 120, Iss 1, Pp 6-14 (2012)
The aim of this in vitro study was to examine the possible effect of [2-methyl-5-(4-methylsulphonyl)phenyl-1-phenyl-3-(2-n-propyloxyethyl)]-1H-pyrrole (VA441), a new selective cyclooxygenase (COX)-2 inhibitor, on human osteoarthritic (OA) chondrocyte
Externí odkaz: https://doaj.org/article/f1e2a923234c4e50b8c64caf177cc22c
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7
Akademický článek
Radiosynthesis and Preliminary Biological Evaluation of [F]VC701, a Radioligand for Translocator Protein
Autor: Giuseppe Di Grigoli, Cristina Monterisi, Sara Belloli, Valeria Masiello, Letterio Salvatore Politi, Salvatore Valenti, Marco Paolino, Maurizio Anzini, Mario Matarrese, Andrea Cappelli, Rosa Maria Moresco
Publikováno v: Molecular Imaging, Vol 14 (2015)
Positron emission tomography (PET) can be used to monitor in vivo translocator protein (TSPO) expression by using specific radioligands. Recently, several [ 11 C]PK11195 analogues have been synthesized to improve binding stability and brain availabil
Externí odkaz: https://doaj.org/article/ab9e1ef4ee684a48a9938816d8ee4eb9
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8
Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria
Autor: Antonio Giordani, Marco Paolino, Mario Saletti, Andrea Cappelli, Germano Giuliani, Mario Matarrese, Maurizio Anzini, Rosa Maria Moresco, Maria Cristina Menziani
Publikováno v: Journal of medicinal chemistry (Online) 64 (2021): 9649–9676. doi:10.1021/acs.jmedchem.1c00379
info:cnr-pdr/source/autori:Giordani A.; Menziani M.C.; Moresco R.M.; Matarrese M.; Paolino M.; Saletti M.; Giuliani G.; Anzini M.; Cappelli A./titolo:Exploring Translocator Protein (TSPO) Medicinal Chemistry: An Approach for Targeting Radionuclides and Boron Atoms to Mitochondria/doi:10.1021%2Facs.jmedchem.1c00379/rivista:Journal of medicinal chemistry (Online)/anno:2021/pagina_da:9649/pagina_a:9676/intervallo_pagine:9649–9676/volume:64
Translocator protein 18 kDa [TSPO or peripheral-type benzodiazepine receptor (PBR)] was identified in the search of binding sites for benzodiazepine anxiolytic drugs in peripheral regions. In these areas, binding sites for TSPO ligands were recognize
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5bdc30ddc691e6ffdd212db66cfe6e
http://hdl.handle.net/11365/1217477
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9
Hyaluronan Graft Copolymers Bearing Fatty-Acid Residues as Self-Assembling Nanoparticles for Olanzapine Delivery
Autor: Andrea Cappelli, Gaetano Giammona, Germano Giuliani, Hartmut Komber, Annalisa Reale, Maurizio Anzini, Marco Paolino, Gemma Leone, Alessandro Donati, Laura Modica de Mohac, Mariano Licciardi, Agnese Magnani, Cristina Savoca
Publikováno v: Pharmaceutics
Volume 11
Issue 12
In order to evaluate the potential of a technology platform based on hyaluronan copolymers grafted with propargylated ferulate fluorophores (HA-FA-Pg) in the development of drug delivery systems, the propargyl groups of HA-FA-Pg derivatives were empl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e497a2efd4397e7ad6ecdee2728b53
http://hdl.handle.net/10447/387574
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10
Therapeutic potential for coxibs-nitric oxide releasing hybrids in cystic fibrosis
Autor: Annalisa Bruno, Antonio Giordani, Giovanna Poce, Sara Consalvi, Maurizio Anzini, Lorenzo Di Cesare Mannelli, Alma Martelli, Paola Patrignani, Lara Testai, Mariangela Biava, Vincenzo Calderone, Carla Ghelardini
Publikováno v: European journal of medicinal chemistry. 210
This review discusses the rational for further studies of COX-2 inhibitors-NO releaser hybrids (NO-Coxibs) in the pharmacological treatment of the airway inflammation in Cystic Fibrosis (CF). Our research group developed several classes of NO-Coxibs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73fceb79fbad521e958311e49c51be7
https://pubmed.ncbi.nlm.nih.gov/33168231
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