Zobrazeno 1 - 10
of 285
pro vyhledávání: '"Maurizio, Pellecchia"'
Autor:
Cassandra Dennys, Carlo Baggio, Rochelle Rodrigo, Florence Roussel, Anna Kulinich, Sarah Heintzman, Ashley Fox, Stephen J. Kolb, Pamela J. Shaw, Iryna M. Ethell, Maurizio Pellecchia, Kathrin C. Meyer
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104877- (2022)
Summary: Amyotrophic lateral sclerosis (ALS) is a degenerative disease that progressively destroys motor neurons (MNs). Earlier studies identified EphA4, a receptor tyrosine kinase, as a possible disease-modifying gene. The complex interplay between
Externí odkaz:
https://doaj.org/article/c75409ffbf4b47f2838cf9114ed20af6
Publikováno v:
Journal of Medicinal Chemistry. 65:15443-15456
Overexpression of the receptor tyrosine kinase EphA2 is invariably associated with poor prognosis and development of aggressive metastatic cancers. Guided by our recently solved X-ray structure of the complex between an agonistic peptide and EphA2-LB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e1df8a654a60ea28b2cc97a7d7d773
https://doi.org/10.1021/acs.jmedchem.2c01391
https://doi.org/10.1021/acs.jmedchem.2c01391
Autor:
Parima Udompholkul, Carlo Baggio, Luca Gambini, Yu Sun, Ming Zhao, Robert M. Hoffman, Maurizio Pellecchia
Publikováno v:
Molecules, Vol 26, Iss 12, p 3687 (2021)
We recently reported on a potent synthetic agent, 135H11, that selectively targets the receptor tyrosine kinase, EphA2. While 135H11 possesses a relatively high binding affinity for the ligand-binding domain of EphA2 (Kd~130 nM), receptor activation
Externí odkaz:
https://doaj.org/article/e060a07dc09243c3b2ebf0875e197001
Autor:
Maurizio Pellecchia, John C. Reed, Said Sebti, Nicholas Lawrence, Tyler A. Reed, Si Wang, Bainan Wu, Ziming Zhang, Russell Dahl, Li Yang, Jiazhi Sun, Dayong Zhai, John L. Stebbins, Jason Cellitti, Hongbin Yuan, Aras Emdadi, Michele F. Rega, Shinichi Kitada, Jun Wei
Guided by a combination of nuclear magnetic resonance binding assays and computational docking studies, we synthesized a library of 5,5′ substituted Apogossypol derivatives as potent Bcl-XL antagonists. Each compound was subsequently tested for its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604ac48de033a8db9e0fdc42766287b4
https://doi.org/10.1158/1535-7163.c.6531807
https://doi.org/10.1158/1535-7163.c.6531807
Autor:
Maurizio Pellecchia, John C. Reed, Said Sebti, Nicholas Lawrence, Tyler A. Reed, Si Wang, Bainan Wu, Ziming Zhang, Russell Dahl, Li Yang, Jiazhi Sun, Dayong Zhai, John L. Stebbins, Jason Cellitti, Hongbin Yuan, Aras Emdadi, Michele F. Rega, Shinichi Kitada, Jun Wei
Supplementary Data from Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95bebc910184fa8416d57f584ffdc4e
https://doi.org/10.1158/1535-7163.22485165
https://doi.org/10.1158/1535-7163.22485165
Autor:
Maurizio Pellecchia, Paul B. Fisher, Elena B. Pasquale, Shinichi Kitada, Neil A. Bhowmick, Ana Fernandez, Sandrine Billet, Sayantan Mitra, Bainan Wu, Ziming Zhang, Swadesh Das, John L. Stebbins, Roberta Noberini, Si Wang
PDF file - 328K, Scheme 1. Synthesis of YNH motif and dYNH motif Scheme S2. Synthetic route for YSA-PTX Figure S1. In vivo prostate cancer xenograft studies. Figure S2. EphA2 expression in RENCA renal carcinoma cells and PC3M prostate cancer cells. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d69e65203ba867b59145059bb021e77
https://doi.org/10.1158/1078-0432.22446387.v1
https://doi.org/10.1158/1078-0432.22446387.v1
Autor:
Maurizio Pellecchia, Paul B. Fisher, Elena B. Pasquale, Shinichi Kitada, Neil A. Bhowmick, Ana Fernandez, Sandrine Billet, Sayantan Mitra, Bainan Wu, Ziming Zhang, Swadesh Das, John L. Stebbins, Roberta Noberini, Si Wang
Purpose: YSA is an EphA2-targeting peptide that effectively delivers anticancer agents to prostate cancer tumors. Here, we report on how we increased the drug-like properties of this delivery system.Experimental Design: By introducing non-natural ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058e0bf87b375d073d5ba1bd8ddba197
https://doi.org/10.1158/1078-0432.c.6520734
https://doi.org/10.1158/1078-0432.c.6520734
Autor:
Paul B. Fisher, Devanand Sarkar, Maurizio Pellecchia, Jun Wei, Luni Emdad, Swadesh K. Das, Praveen Bhoopathi, Belal Azab, Siddik Sarkar, Rupesh Dash, Bridget A. Quinn
Supplementary Figure Legends 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b38ce6dcfda5e5f6486959fe013c50
https://doi.org/10.1158/0008-5472.22405659.v1
https://doi.org/10.1158/0008-5472.22405659.v1
Autor:
Paul B. Fisher, Devanand Sarkar, Maurizio Pellecchia, Jun Wei, Luni Emdad, Swadesh K. Das, Praveen Bhoopathi, Belal Azab, Siddik Sarkar, Rupesh Dash, Bridget A. Quinn
Supplementary Figures 1-9. Sabutoclax has greater efficacy than ABT-737. (S1) Sabutoclax causes a G1-S phase cell cycle arrest. (S2) Pancreatic cancer cells exhibit varying levels of sensitivity to Minocycline. (S3) Sabutoclax and Minocycline induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a38742b61075d45a92f1f344e7395c9
https://doi.org/10.1158/0008-5472.22405650.v1
https://doi.org/10.1158/0008-5472.22405650.v1
Autor:
Paul B. Fisher, Devanand Sarkar, John C. Reed, Maurizio Pellecchia, Steven Grant, David T. Curiel, Igor P. Dmitriev, Paul Dent, Adly Yacoub, Girija Dasmahapatra, Mohamed Rahmani, Belal Azab, Sujit K. Bhutia, Zhao-zhong Su, Joanna E. Richards, Rupesh Dash
Supplementary Figure 1, Table 1 from Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbd3c2e87d964277d42027afa89be0e
https://doi.org/10.1158/0008-5472.22383198.v1
https://doi.org/10.1158/0008-5472.22383198.v1