Zobrazeno 1 - 10
of 642
pro vyhledávání: '"Maurizio, Botta"'
Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity
Autor:
Diego Fiorucci, Micaela Meaccini, Giulio Poli, Maria Alfreda Stincarelli, Chiara Vagaggini, Simone Giannecchini, Priscila Sutto-Ortiz, Bruno Canard, Etienne Decroly, Elena Dreassi, Annalaura Brai, Maurizio Botta
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2437 (2024)
Zika virus (ZIKV) is a positive-sense single-stranded virus member of the Flaviviridae family. Among other arboviruses, ZIKV can cause neurological disorders such as Guillain Barré syndrome, and it can have congenital neurological manifestations and
Externí odkaz:
https://doaj.org/article/0afb7cf099f34ac8aef2b89648debb2a
Autor:
Fernanda A. H. Batista, Sérgio L. Ramos, Giusy Tassone, Andrei Leitão, Carlos A. Montanari, Maurizio Botta, Mattia Mori, Júlio C. Borges
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 639-649 (2020)
Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These
Externí odkaz:
https://doaj.org/article/1eb2af2ab0394a7fb2e4c0e33e4550a4
Publikováno v:
ARKIVOC, Vol 2019, Iss 4, Pp 168-177 (2019)
Externí odkaz:
https://doaj.org/article/7bb76cfe019d44b6a02a4c94f8917678
Autor:
Leire Iralde-Lorente, Ylenia Cau, Letizia Clementi, Lorenzo Franci, Giusy Tassone, Daniela Valensin, Mattia Mori, Adriano Angelucci, Mario Chiariello, Maurizio Botta
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 657-664 (2019)
14-3-3 are regulatory proteins that through protein–protein interactions (PPI) with numerous binding partners could be involved in several human diseases, including cancer, neurodegenerative disorders, and pathogens infections. Following our resear
Externí odkaz:
https://doaj.org/article/0387ca67151143d8bee11b1f00a12246
Autor:
Enrico Rango, Salvatore Di Maria, Claudio Zamperini, Federica Poggialini, Emmanuele Crespan, Cecilia Perini, Samantha Sabetta, Simona Saponara, Fabio Fusi, Giovanni Maga, Adriano Angelucci, Eugenio Gaudio, Francesco Berton, Silvia Schenone, Lorenzo Botta, Elena Dreassi, Maurizio Botta
Publikováno v:
Pharmaceutical Chemistry Journal. 56:1616-1626
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::234f0006daf6b3240551930e53465813
https://doi.org/10.1007/s11094-023-02836-x
https://doi.org/10.1007/s11094-023-02836-x
Autor:
Enrico Rango, Fabio Pastorino, Chiara Brignole, Arianna Mancini, Federica Poggialini, Salvatore Di Maria, Claudio Zamperini, Giulia Iovenitti, Anna Lucia Fallacara, Samantha Sabetta, Letizia Clementi, Massimo Valoti, Silvia Schenone, Adriano Angelucci, Mirco Ponzoni, Elena Dreassi, Maurizio Botta
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 659 (2022)
Si306, a pyrazolo[3,4-d]pyrimidine derivative recently identified as promising anticancer agent, has shown favorable in vitro and in vivo activity profile against neuroblastoma (NB) models by acting as a competitive inhibitor of c-Src tyrosine kinase
Externí odkaz:
https://doaj.org/article/76fcd042be33447e9734d22a84d6e765
Autor:
Federica Pessina, Maria Frosini, Paola Marcolongo, Fabio Fusi, Simona Saponara, Alessandra Gamberucci, Massimo Valoti, Daniela Giustarini, Paolo Fiorenzani, Beatrice Gorelli, Valeria Francardi, Maurizio Botta, Elena Dreassi
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233788 (2020)
In pre-hypertension, moderate control of blood pressure (BP) can be obtained by a nutritional approach. The effects of a diet enriched with defatted larvae of the mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) (TM) endowed with ACE inhibitory
Externí odkaz:
https://doaj.org/article/78375ad41d2d45c0a1fc0791bda3cd5a
Autor:
Adriano Angelucci, Maurizio Botta, Silvia Schenone, Flora Vitale, Claudia Mattei, Giovanni Luca Gravina, Ernesto Di Cesare, Claudio Festuccia, Federica Coniglio, Claudio Zamperini, Giulia Vignaroli, Alessia Calgani
Supplementary table s1 + supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f13a87275688ceb25a223e25bb651d9
https://doi.org/10.1158/1535-7163.22508364
https://doi.org/10.1158/1535-7163.22508364
Autor:
Antonia Diukendjieva, Maya M. Zaharieva, Mattia Mori, Petko Alov, Ivanka Tsakovska, Tania Pencheva, Hristo Najdenski, Vladimír Křen, Chiara Felici, Francesca Bufalieri, Lucia Di Marcotullio, Bruno Botta, Maurizio Botta, Ilza Pajeva
Publikováno v:
Antioxidants, Vol 9, Iss 5, p 384 (2020)
Silymarin is the standardized extract from the fruits of Silybum marianum (L.) Gaertn., a well-known hepatoprotectant and antioxidant. Recently, bioactive compounds of silymarin, i.e., silybins and their 2,3-dehydro derivatives, have been shown to ex
Externí odkaz:
https://doaj.org/article/551d960846c64a6b9348bde0495e3085
Autor:
Valeria Cagno, Cristina Tintori, Andrea Civra, Roberta Cavalli, Marika Tiberi, Lorenzo Botta, Annalaura Brai, Giulio Poli, Caroline Tapparel, David Lembo, Maurizio Botta
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208333 (2018)
Viral infections are an important cause of death worldwide. Unfortunately, there is still a lack of antiviral drugs or vaccines for a large number of viruses, and this represents a remarkable challenge particularly for emerging and re-emerging viruse
Externí odkaz:
https://doaj.org/article/e8c633debfbb41c39410c7b18449093c