Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Maurits A. Jansen"'
Autor:
Gregorio Naredo-Gonzalez, Rita Upreti, Maurits A. Jansen, Scott Semple, Oliver B. Sutcliffe, Ian Marshall, Brian R. Walker, Ruth Andrew
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies tissue glucocorticoid levels and is a pharmaceutical target in diabetes and cognitive decline. Clinical translation of inhibitors is hampered by lack of in vivo pharmacodynamic b
Externí odkaz:
https://doaj.org/article/6a9028e7cc0f46658c806d04000708a5
Autor:
Marion Bonneau, Shane T. O’ Sullivan, Miguel A. Gonzalez-Lozano, Paul Baxter, Phillippe Gautier, Elena Marchisella, Neil R. Hardingham, Robert A. Chesters, Helen Torrance, David M. Howard, Maurits A. Jansen, Melanie McMillan, Yasmin Singh, Michel Didier, Frank Koopmans, Colin A. Semple, Andrew M. McIntosh, Hansjürgen Volkmer, Maarten Loos, Kevin Fox, Giles E. Hardingham, Anthony C. Vernon, David J. Porteous, August B. Smit, David J. Price, J. Kirsty Millar
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract A balanced t(1;11) translocation that directly disrupts DISC1 is linked to schizophrenia and affective disorders. We previously showed that a mutant mouse, named Der1, recapitulates the effect of the translocation upon DISC1 expression. Here
Externí odkaz:
https://doaj.org/article/392e0db05f914e418b87d06cd79f30fb
Autor:
Mosi Li, Akihiro Kitamura, Joshua Beverley, Juraj Koudelka, Jessica Duncombe, Ross Lennen, Maurits A. Jansen, Ian Marshall, Bettina Platt, Ulrich K. Wiegand, Roxana O. Carare, Rajesh N. Kalaria, Jeffrey J. Iliff, Karen Horsburgh
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
Large vessel disease and carotid stenosis are key mechanisms contributing to vascular cognitive impairment (VCI) and dementia. Our previous work, and that of others, using rodent models, demonstrated that bilateral common carotid stenosis (BCAS) lead
Externí odkaz:
https://doaj.org/article/24b532b621764d6c85fdb1fb3b919ba1
Autor:
Jacek Kwiecinski, Ross J. Lennen, Gillian A. Gray, Gary Borthwick, Lyndsey Boswell, Andrew H. Baker, David E. Newby, Marc R. Dweck, Maurits A. Jansen
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 22, Iss 1, Pp 1-11 (2020)
Abstract Background Myocardial fibrosis is observed in multiple cardiac conditions including hypertension and aortic stenosis. Excessive fibrosis is associated with adverse clinical outcomes, but longitudinal human data regarding changes in left vent
Externí odkaz:
https://doaj.org/article/85c00658de8e4f9f9cc2e07774bfd95e
Autor:
Lucy E Kershaw, David ML Lilburn, Maurits A. Jansen, Andrew R Bond, Salamah M Alwahsh, Pilar Jimenez-Royo, Antonella Napolitano, Philip Murphy, Alexandra Roberts, Rob Janiczek, Shareen Forbes, Scott IK Semple
Publikováno v:
Journal of Magnetic Resonance Open, Vol 1, Iss , Pp 100002- (2019)
Mangafodipir was approved for use as an MRI contrast agent in the late 1990s for liver and pancreas imaging but it was removed from the European market for commercial reasons in 2012. Previously, preliminary work in mice and in diabetic patients show
Externí odkaz:
https://doaj.org/article/6351a502e722460a86011c10635b6b66
Autor:
Anna M. Hoy, Natasha McDonald, Ross J. Lennen, Matteo Milanesi, Amy H. Herlihy, Timothy J. Kendall, William Mungall, Michael Gyngell, Rajarshi Banerjee, Robert L. Janiczek, Philip S. Murphy, Maurits A. Jansen, Jonathan A. Fallowfield
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
Non-invasive quantitation of liver disease using multiparametric magnetic resonance imaging (MRI) could refine clinical care pathways, trial design and preclinical drug development. The aim of this study was to evaluate the use of multiparametric MRI
Externí odkaz:
https://doaj.org/article/1b426a0f0e31422f831a288be36cea76
Autor:
Sophie Quick, Tessa V. Procter, Jonathan Moss, Luise Seeker, Marc Walton, Angus Lawson, Serena Baker, Anna Beletski, Daniela Jaime Garcia, Mehreen Mohammad, William Mungall, Ami Onishi, Zuzanna Tobola, Michael Stringer, Maurits A. Jansen, Antoine Vallatos, Ylenia Giarratano, Miguel O. Bernabeu, Joanna M. Wardlaw, Anna Williams
Publikováno v:
Quick, S, Procter, T, Moss, J, Seeker, L, Walton, M, Lawson, A, Baker, S, Beletski, A, Jaime Garcia, D, Mohammad, M, Mungall, W, Onishi, A, Tobola, Z, Stringer, M, Jansen, M, Vallatos, A, Giarratano, Y, Bernabeu, M O, Wardlaw, J M & Williams, A C 2022, ' Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model ', Acta Neuropathologica, vol. 144, no. 2, pp. 283-303 . https://doi.org/10.1007/s00401-022-02441-4
Cerebral small vessel disease (SVD) is the leading cause of vascular dementia, causes a quarter of strokes, and worsens stroke outcomes. The disease is characterised by patchy cerebral small vessel and white matter pathology, but the underlying mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9b07d7548a989cc06a0f836a7abaac
https://www.pure.ed.ac.uk/ws/files/280682874/ANEU_D_22_00297_R1_1_.pdf
https://www.pure.ed.ac.uk/ws/files/280682874/ANEU_D_22_00297_R1_1_.pdf
Autor:
Sophie Quick, Tessa V. Procter, Jonathan Moss, Angus Lawson, Serena Baker, Marc Walton, Mehreen Mohammad, Will Mungall, Ami Onishi, Zuzanna Tobola, Michael Stringer, Maurits A. Jansen, Antoine Vallatos, Ylenia Giarratano, Miguel O. Bernabeu, Joanna M. Wardlaw, Anna C. Williams
Small Vessel Disease (SVD) is the leading cause of vascular dementia, causes a quarter of strokes, and worsens stroke outcomes(1, 2). The disease is characterised by cerebral small vessel and white matter pathology, but the underlying mechanisms are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95570f5c269c2db206e87f5a63a4c2a8
https://doi.org/10.1101/2021.12.13.472377
https://doi.org/10.1101/2021.12.13.472377
Autor:
Scott Semple, Oliver B. Sutcliffe, Gregorio Naredo-Gonzalez, Brian R. Walker, Ian Marshall, Rita Upreti, Maurits A. Jansen, Ruth Andrew
Publikováno v:
Naredo-Gonzalez, G, Upreti, R, Jansen, M A, Semple, S, Sutcliffe, O B, Marshall, I, Walker, B R & Andrew, R 2022, ' Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19 F-magnetic resonance spectroscopy ', Scientific Reports . https://doi.org/10.1038/s41598-022-18740-5
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies tissue glucocorticoid levels and is a pharmaceutical target in diabetes and cognitive decline. Clinical translation of inhibitors is hampered by lack of in vivo pharmacodynamic biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46dbfda0addb6e5dc4d569e04ffd9bd
https://doi.org/10.21203/rs.3.rs-943640/v1
https://doi.org/10.21203/rs.3.rs-943640/v1
Autor:
Gregorio, Naredo-Gonzalez, Rita, Upreti, Maurits A, Jansen, Scott, Semple, Oliver B, Sutcliffe, Ian, Marshall, Brian R, Walker, Ruth, Andrew
Publikováno v:
Scientific reports. 12(1)
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies tissue glucocorticoid levels and is a pharmaceutical target in diabetes and cognitive decline. Clinical translation of inhibitors is hampered by lack of in vivo pharmacodynamic biomarkers