Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Maurilio José, Soares"'
Autor:
Christian Bustamante, Andrés Felipe Díez-Mejía, Natalia Arbeláez, Maurilio José Soares, Sara M. Robledo, Rodrigo Ochoa, Rubén E. Varela-M., Marcel Marín-Villa
Publikováno v:
Pathogens, Vol 11, Iss 6, p 616 (2022)
The lack of therapeutic alternatives for the treatment of Chagas disease, a neglected disease, drives the discovery of new drugs with trypanocidal activity. Consequently, we conducted in vitro studies using UBMC-4, a potential Trypanosoma cruzi AKT-l
Externí odkaz:
https://doaj.org/article/accd649222414eeeaed25721cc212126
Publikováno v:
BMC Cell Biology, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background The palmitate analogue 2-bromopalmitate (2-BP) is a non-selective membrane tethered cysteine alkylator of many membrane-associated enzymes that in the last years emerged as a general inhibitor of protein S-palmitoylation. Palmitoy
Externí odkaz:
https://doaj.org/article/ceb396da67a94ce6a1045848da346479
Autor:
Cassiano Martin Batista, Felipe Saad, Stephane Pini Costa Ceccoti, Iriane Eger, Maurilio José Soares
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 113, Iss 8 (2018)
Dynamic S-palmitoylation of proteins is the addition of palmitic acid by zDHHC palmitoyl transferases (PATs) and depalmitoylation by palmitoyl protein thioesterases (PPTs). A putative PAT (TcPAT1) has been previously identified in Trypanosoma cruzi,
Externí odkaz:
https://doaj.org/article/adf2474f3f384d15b0773573975e5090
Autor:
Claudia Maria do Nascimento Moreira, Cassiano Martin Batista, Jessica Chimenes Fernandes, Rafael Luis Kessler, Maurilio José Soares, Stenio Perdigão Fragoso
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0179615 (2017)
The AP-1 Adaptor Complex assists clathrin-coated vesicle assembly in the trans-Golgi network (TGN) of eukaryotic cells. However, the role of AP-1 in the protozoan Trypanosoma cruzi-the Chagas disease parasite-has not been addressed. Here, we studied
Externí odkaz:
https://doaj.org/article/d306ff8704e64d21ac488eb00dd68ac8
Autor:
Ligia Cristina Kalb Souza, Rosana Elisa Gonçalves Gonçalves Pinho, Carla Vanessa de Paula Lima, Stênio Perdigão Fragoso, Maurilio José Soares
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 108, Iss 5, Pp 631-636 (2013)
Heteroxenic and monoxenic trypanosomatids were screened for the presence of actin using a mouse polyclonal antibody produced against the entire sequence of the Trypanosoma cruzi actin gene, encoding a 41.9 kDa protein. Western blot analysis showed th
Externí odkaz:
https://doaj.org/article/2a9ae724d9a241d1a1e219b91c8c6319
The zinc finger protein TcZFP2 binds target mRNAs enriched during Trypanosoma cruzi metacyclogenesis
Autor:
Patricia Alves Mörking, Rita de Cássia Pontello Rampazzo, Pegine Walrad, Christian Macagnan Probst, Maurilio José Soares, Daniela Fiori Gradia, Daniela Parada Pavoni, Marco Aurélio Krieger, Keith Matthews, Samuel Goldenberg, Stenio Perdigão Fragoso, Bruno Dallagiovanna
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 107, Iss 6, Pp 790-799 (2012)
Trypanosomes are parasitic protozoa in which gene expression is primarily controlled through the regulation of mRNA stability and translation. This post-transcriptional control is mediated by various families of RNA-binding proteins, including those
Externí odkaz:
https://doaj.org/article/afdd73dee3e141568cec406cd136e58a
Autor:
Josiane Cardoso, Maurilio José Soares
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 105, Iss 8, Pp 1026-1032 (2010)
Citral, the main constituent of lemongrass (Cymbopogon citratus) essential oil, was added to Trypanosoma cruzi cultures grown in TAU3AAG medium to observe the effect on the epimastigote-to-trypomastigote differentiation process (metacyclogenesis). Ou
Externí odkaz:
https://doaj.org/article/09032ea032ae436db8cd988bf8f83eff
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130165 (2015)
Epimastigote forms of Trypanosoma cruzi (the etiologic agent of Chagas disease) internalize and store extracellular macromolecules in lysosome-related organelles (LROs) called reservosomes, which are positive for the cysteine protease cruzipain. Desp
Externí odkaz:
https://doaj.org/article/35b1145bf3134fb699113ff616d6471e
Autor:
José Andrés Morgado-Díaz, Raquel Elisa da Silva-Lopez, Carlos Roberto Alves, Maurilio José Soares, Suzana Corte-Real, Salvatore Giovanni De Simone
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 100, Iss 4, Pp 377-383 (2005)
Here we report the subcellular localization of an intracellular serine protease of 68 kDa in axenic promastigotes of Leishmania (Leishmania) amazonensis, using subcellular fractionation, enzymatic assays, immunoblotting, and immunocytochemistry. All
Externí odkaz:
https://doaj.org/article/060fb2e78a3540ea9fabfee3e71b75d3
Autor:
Adelaide Tardin Monnerat, Marcelo Pelajo Machado, Bruno Silva Vale, Maurilio José Soares, José Bento Pereira Lima, Henrique Leonel Lenzi, Denise Valle
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 97, Iss 4, Pp 589-596 (2002)
Anopheles albitarsis embryogenesis was analyzed through confocal microscopy of clarified eggs. Using Drosophila melanogaster as reference system, the major morphogenetic events (blastoderm, gastrulation, germ band extension, germ band retraction, dor
Externí odkaz:
https://doaj.org/article/e7e6807d4d224840acb72911c5f23369