Výsledky vyhledávání - "Maurilio, Ponzoni"

Akademický článek

In vitro models of the crosstalk between multiple myeloma and stromal cells recapitulate the mild NF-κB activation observed in vivo

Autor: Federica Colombo, Virginia Guzzeloni, Cise Kizilirmak, Francesca Brambilla, Jose Manuel Garcia-Manteiga, Anna Sofia Tascini, Federica Moalli, Francesca Mercalli, Maurilio Ponzoni, Rosanna Mezzapelle, Marina Ferrarini, Elisabetta Ferrero, Roberta Visone, Marco Rasponi, Marco E. Bianchi, Samuel Zambrano, Alessandra Agresti

Publikováno v: Cell Death and Disease, Vol 15, Iss 10, Pp 1-18 (2024)

Abstract Multiple myeloma (MM) is linked to chronic NF-κB activity in myeloma cells, but this activity is generally considered a cell-autonomous property of the cancer cells. The precise extent of NF-κB activation and the contributions of the physi

Externí odkaz: https://doaj.org/article/2b833cbac6f74de29ad22d2eeeb90e79

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Akademický článek

DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

Deficient (d) DNA mismatch repair (MMR) is a biomarker predictive of better response to PD-1 blockade immunotherapy in solid tumors. dMMR can be caused by mutations in MMR genes or by protein inactivation, which can be detected by sequencing and immu

Externí odkaz: https://doaj.org/article/5de2138da31648e09e4ad55f932a3cf2

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Akademický článek

Spontaneous remission of choroidal involvement by chronic myelomonocytic leukemia: a case report

Autor: Elisa Diral, Gloria Catalano, Maria Vittoria Cicinelli, Andrea Distefano, Sara Mastaglio, Luca Vago, Maria Teresa Lupo Stanghellini, Massimo Bernardi, Maurilio Ponzoni, Fabio Ciceri, Matteo G. Carrabba

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

Chronic myelomonocytic leukemia (CMML) is a rare hematological disorder characterized by variable risk of evolution to acute myeloid leukemia; to date, allogeneic stem cell transplantation is the only curative treatment. We report a case of choroidal

Externí odkaz: https://doaj.org/article/292895b18986410bb29e80b01f537dbc

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Akademický článek

ZEB1 shapes AML immunological niches, suppressing CD8 T cell activity while fostering Th17 cell expansion

Publikováno v: Cell Reports, Vol 43, Iss 2, Pp 113794- (2024)

Summary: Acute myeloid leukemia (AML) progression is influenced by immune suppression induced by leukemia cells. ZEB1, a critical transcription factor in epithelial-to-mesenchymal transition, demonstrates immune regulatory functions in AML. Silencing

Externí odkaz: https://doaj.org/article/da7ae959a4304ef9b858b1b572ed0a44

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Akademický článek

Case report: Cytopenias in VEXAS syndrome - a WHO 2022 based approach in a single-center cohort

Autor: Elisa Diral, Corrado Campochiaro, Alessandro Tomelleri, Gregorio M. Bergonzi, Umberto Pizzano, Maurilio Ponzoni, Lucia Bongiovanni, Paola Ronchi, Cristina Tresoldi, Silvia Rigamonti, Federico Scarfò, Gloria M. Latino, Emma Rinaldi, Massimo Bernardi, Lorenzo Dagna, Fabio Ciceri

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

VEXAS syndrome is an acquired autoinflammatory disease characterized in most cases by cytopenias and macrocytic anemia. Dyshematopoiesis is a frequent finding in chronic inflammatory conditions and therefore, cytopenias are not easily classified in V

Externí odkaz: https://doaj.org/article/81b163f856f2468ba4cce34336fc3afe

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Akademický článek

B Lymphoproliferative Neoplasms of Uncertain Biological Significance: Report from the IV Workshop of the Italian Group of Hematopathology and Review of the Literature

Autor: Gioia Di Stefano, Francesca Magnoli, Massimo Granai, Federico Vittone, Raffaella Santi, Domenico Ferrara, Emanuela Boveri, Ada M. Florena, Falko Fend, Elena Sabattini, Marco Paulli, Maurilio Ponzoni, Stefano Lazzi, Stefano A. Pileri, Lorenzo Leoncini, the Italian Group of Hematopathology

Publikováno v: Hemato, Vol 3, Iss 4, Pp 634-649 (2022)

Lymphoproliferative neoplasms of uncertain biological significance are increasingly encountered due to widespread usage of immunophenotypic and molecular techniques. Considering that clearer biological criteria and patient management have been establ

Externí odkaz: https://doaj.org/article/ee0b868f752741bd9b75d3b9a85715a1

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Akademický článek

Determining clinical course of diffuse large B-cell lymphoma using targeted transcriptome and machine learning algorithms

Publikováno v: Blood Cancer Journal, Vol 12, Iss 2, Pp 1-9 (2022)

Abstract Multiple studies have demonstrated that diffuse large B-cell lymphoma (DLBCL) can be divided into subgroups based on their biology; however, these biological subgroups overlap clinically. Using machine learning, we developed an approach to s

Externí odkaz: https://doaj.org/article/93888a803eda4609ab485bda57596d9c

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Akademický článek

Case report: Successful use of mepolizumab for immune checkpoint inhibitors–induced hypereosinophilic syndrome in two patients with solid malignancies

Autor: Chiara Lazzari, Mona Rita Yacoub, Corrado Campochiaro, Alessandra Bulotta, Diego Palumbo, Francesca Rita Ogliari, Lorenzo Dagna, Silvia Marchesi, Maurilio Ponzoni, Vanesa Gregorc

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

Hypereosinophilic syndrome (HES) represents a group of blood disorders characterized by an absolute eosinophil count (AEC) > 1.5 × 103/μl in the peripheral blood, which eventually extravasate and cause organ damage. It can be primary or secondary t

Externí odkaz: https://doaj.org/article/793e50f9596b45d9af8946795fd0f08f

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