Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Mauricio Leal"'
Autor:
Parul Gupta, Ziyue Karen Jiang, Bing Yang, Lisa Manzuk, Edward Rosfjord, Johnny Yao, Luanna Lemon, Kavon Noorbehesht, John David, Sujiet Puthenveetil, Jeffrey M. Casavant, Elwira Muszynska, Fengping Li, Mauricio Leal, Puja Sapra, Anand Giddabasappa
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
IL13Rα2 is a cell surface tumor antigen that is overexpressed in multiple tumor types. Here, we studied biodistribution and targeting potential of an anti-IL13Rα2 antibody (Ab) and anti-tumor activity of anti-IL13Rα2-antibody-drug conjugate (ADC).
Externí odkaz:
https://doaj.org/article/81c276ef8efc4089980d81c900e94c0d
Autor:
Puja Sapra, Mauricio Leal, Jeetendra Eswaraka, Brian Rago, Joann Wentland, Mary E. Spilker, Parul Gupta, Rand Norberg, Vijay R. Gupta, Anand Giddabasappa
Understanding a drug's whole-body biodistribution and tumor targeting can provide important information regarding efficacy, safety, and dosing parameters. Current methods to evaluate biodistribution include in vivo imaging technologies like positron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2399f3839a6cf277508515b28bdc8354
https://doi.org/10.1158/1535-7163.c.6537595
https://doi.org/10.1158/1535-7163.c.6537595
Autor:
Puja Sapra, Mauricio Leal, Jeetendra Eswaraka, Brian Rago, Joann Wentland, Mary E. Spilker, Parul Gupta, Rand Norberg, Vijay R. Gupta, Anand Giddabasappa
Supplemental Figure 1: Standard curve of VT680 showing the 3-D quantitation and linearity by FMT imaging; Supplemental Figure 2: Evaluation of VT680 conjugated 5T4-Ab and 5T4-ADC; Supplemental Figure 3: Determination of antibody binding capacity (ABC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075b7d40c375fc09d5c8854cd9330898
https://doi.org/10.1158/1535-7163.22504030
https://doi.org/10.1158/1535-7163.22504030
Autor:
Hans-Peter Gerber, Robert T. Abraham, Lioudmila Tchistiakova, Christopher J. O'Donnell, George Hu, Mauricio Leal, Judy Lucas, Elana Ernstoff, Russell Dushin, Kiran Khandke, Andreas Giannakou, Bitha Narayanan, Maureen Dougher, Jonathon Golas, Kenneth G. Geles, Kimberly Marquette, John DiJoseph, Marc Damelin, Puja Sapra
PDF file-458KB, Supplementary Figure S1. Representation of A1mcMMAF and its proposed processing., Supplementary Figure S2. Chromatographic characterization of A1mcMMAF., Supplementary Figure S3. LC-MS analysis of A1mcMMAF ADC., Supplementary Figure S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab9f699b4baa5ba46a527ef133c122d
https://doi.org/10.1158/1535-7163.22498438
https://doi.org/10.1158/1535-7163.22498438
Autor:
Shou-Ching Jaminet, Harold F. Dvorak, Anthony J. Coyle, Leigh Zawel, Anthony Barry, Shoba Shetty, Mauricio Leal, Anson K. Abraham, William B. Snyder, Robert Dunn, Xianjun Cao, Andreas Maderna, Christopher J. O'Donnell, Dan Li, Lioudmila Tchistiakova, Sadhana Jain, Kimberly Marquette, Xiang Zheng, Chi-Iou Lin, Edyta Tyminski, Kelly Knowlton, Alberto Visintin
Supplementary Figures S1-S6. Supplementary Figure S1. Liquid chromatography electrospray ionization tandem mass spectrometry analysis; Supplementary Figure S2. TM4SF1 expression in human breast and colon cancers; Supplementary Figure S3A. Clearance o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d85d555fe06140285b3604e384e0d0
https://doi.org/10.1158/1535-7163.22505884.v1
https://doi.org/10.1158/1535-7163.22505884.v1
Autor:
Puja Sapra, Christopher J. O'Donnell, Frank Loganzo, Lioudmila Tchistiakova, Hans-Peter Gerber, Edward Rosfjord, Andreas Giannakou, Xingzhi Tan, L. Nathan Tumey, Tracey Clark, Manoj B. Charati, Nadira Prashad, Russell Dushin, Andreas Maderna, Madan Katragadda, Mauricio Leal, Fan Jiang, Stephane Thibault, Wenyue Hu, Nicole Piché-Nicholas, Jennifer Kahler, Yoon-Chi Han
Purpose:Mortality due to acute myeloid leukemia (AML) remains high, and the management of relapsed or refractory AML continues to be therapeutically challenging. The reapproval of Mylotarg, an anti-CD33–calicheamicin antibody–drug conjugate (ADC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e6151cbf5978586286de379aa6d507
https://doi.org/10.1158/1078-0432.c.6530030
https://doi.org/10.1158/1078-0432.c.6530030
Autor:
Puja Sapra, Christopher J. O'Donnell, Frank Loganzo, Lioudmila Tchistiakova, Hans-Peter Gerber, Edward Rosfjord, Andreas Giannakou, Xingzhi Tan, L. Nathan Tumey, Tracey Clark, Manoj B. Charati, Nadira Prashad, Russell Dushin, Andreas Maderna, Madan Katragadda, Mauricio Leal, Fan Jiang, Stephane Thibault, Wenyue Hu, Nicole Piché-Nicholas, Jennifer Kahler, Yoon-Chi Han
Supplementary tables & figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158852f333a4ade14168dfd0bff72bfb
https://doi.org/10.1158/1078-0432.22478732.v1
https://doi.org/10.1158/1078-0432.22478732.v1
Publikováno v:
Approche Centrée sur la Personne. Pratique et recherche. :5-20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::417b48a36138e9a4b0e897aab8ad03d8
https://doi.org/10.3917/acp.031.0005
https://doi.org/10.3917/acp.031.0005
Publikováno v:
Approche Centrée sur la Personne. Pratique et recherche. :47-61
L’Approche centree sur la personne propose une theorie elaboree du developpement humain qui est fondamentale pour une pratique moderne de la psychotherapie, de l’education, pour les pratiques organisationnelles ainsi que pour la recherche. Nonobs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196a5c1773060b79bd297e5f67b0de2b
https://doi.org/10.3917/acp.030.0047
https://doi.org/10.3917/acp.030.0047
Autor:
Andrea T. Hooper, Kimberly Marquette, Chao-Pei Betty Chang, Jonathon Golas, Sadhana Jain, My-Hanh Lam, Magali Guffroy, Mauricio Leal, Hadi Falahatpisheh, Divya Mathur, Ting Chen, Kerry Kelleher, Kiran Khandke, Elwira Muszynska, Frank Loganzo, Edward Rosfjord, Judy Lucas, Zhengyan Kan, Chakrapani Subramanyam, Christopher O'Donnell, Dario Neri, Hans-Peter Gerber, Chad May, Puja Sapra
Publikováno v:
Molecular Cancer Therapeutics, 21 (9)
Extra domain B splice variant of fibronectin (EDB+FN) is an extracellular matrix protein (ECM) deposited by tumor-associated fibroblasts, and is associated with tumor growth, angiogenesis, and invasion. We hypothesized that EDB+FN is a safe and abund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44280b7bd0d0ff36d0379889e945c1e