Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mauricio G. S. Costa"'
Autor:
Burak T. Kaynak, James M. Krieger, Balint Dudas, Zakaria L. Dahmani, Mauricio G. S. Costa, Erika Balog, Ana Ligia Scott, Pemra Doruker, David Perahia, Ivet Bahar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Recent years have seen several hybrid simulation methods for exploring the conformational space of proteins and their complexes or assemblies. These methods often combine fast analytical approaches with computationally expensive full atomic molecular
Externí odkaz:
https://doaj.org/article/902b2f3af6304360bc36b423da15694c
Autor:
Mauricio G. S. Costa, Paulo R. Batista, Antoniel Gomes, Leonardo S. Bastos, Maxime Louet, Nicolas Floquet, Paulo M. Bisch, David Perahia
Publikováno v:
Journal of Chemical Theory and Computation. 19:412-425
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86374a2d4fdcfda029d936f08549e33a
https://doi.org/10.1021/acs.jctc.2c00599
https://doi.org/10.1021/acs.jctc.2c00599
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 88:1675-1687
Network theory methods and molecular dynamics (MD) simulations are accepted tools to study allosteric regulation. Indeed, dynamic networks built upon correlation analysis of MD trajectories provide detailed information about communication paths betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a8c9148e919209f52f4f886b8e339a
https://doi.org/10.1002/prot.25985
https://doi.org/10.1002/prot.25985
Publikováno v:
Journal of Chemical Information and Modeling. 60:2419-2423
Previous studies demonstrated the efficiency of the Molecular Dynamics with excited Normal Modes (MDeNM) method on the characterization of large structural changes at a low computational cost. We present here MDeNM-EMfit, an extension of the original
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42975f211aea51970a9d3bbc47fd98c5
https://doi.org/10.1021/acs.jcim.9b01148
https://doi.org/10.1021/acs.jcim.9b01148
Autor:
Blake T Riley, Sebastian S Broendum, Cyril F Reboul, Nathan P Cowieson, Mauricio G S Costa, Itamar Kass, Colin Jackson, David Perahia, Ashley M Buckle, Sheena McGowan
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140219 (2015)
The growing problem of antibiotic resistance underlies the critical need to develop new treatments to prevent and control resistant bacterial infection. Exogenous application of bacteriophage lysins results in rapid and specific destruction of Gram-p
Externí odkaz:
https://doaj.org/article/cdbca4d9d511430e9514547cbd529bd8
Autor:
Xianyao Xu, Kenneth R. Laurita, Dandan Yang, Adrienne T. Dennis, Xiaoping Wan, Daniel Gratz, Charline Fagnen, Zhihua Wang, Mauricio G. S. Costa, Catherine Vénien-Bryan, Emre Bektik, Isabelle Deschenes, Ji-Dong Fu, Thomas J. Hund, Peter J. Mohler
Publikováno v:
Heart Rhythm. 18:S34-S35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8619186e63db90524fe7b71ba3cc16cb
https://doi.org/10.1016/j.hrthm.2021.06.102
https://doi.org/10.1016/j.hrthm.2021.06.102
Autor:
Ji-Dong Fu, Emre Bektik, Peter J. Mohler, Kenneth R. Laurita, Adrienne T. Dennis, Xianyao Xu, Dandan Yang, Thomas J. Hund, Mauricio G. S. Costa, Zhihua Wang, Catherine Vénien-Bryan, Isabelle Deschenes, Xiaoping Wan, Charline Fagnen
Publikováno v:
Circulation. 142
Background: Cardiac arrhythmias are a leading cause of morbidity and mortality. MicroRNAs (miRs) regulate the (electro) physiology of the heart and remodeling by canonical RNAi mechanism. Hypothesis: miRs maintain cardiac physiology also through nonc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53138a7d703167641e3b04c3b44f4aff
https://doi.org/10.1161/circ.142.suppl_3.15963
https://doi.org/10.1161/circ.142.suppl_3.15963
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics. 1868(1)
Fungi cellulases are used to degrade cellulose-containing biomass for bioethanol production. Industrial cellulases such as Cel7A from Trichoderma reesei (TrCel7A) are critical in this process. Thus, the understanding of structure and dynamics is cruc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415fd1b2210b89347126d6737f7865f5
https://pubmed.ncbi.nlm.nih.gov/31279935
https://pubmed.ncbi.nlm.nih.gov/31279935
Autor:
Fabio Passetti, Ernesto Raul Caffarena, Deborah Antunes, Natasha Andressa Nogueira Jorge, Mauricio G. S. Costa
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Riboswitches are RNA sensors that affect post-transcriptional processes through their ability to bind to small molecules. Thiamine pyrophosphate (TPP) riboswitch class is the most widespread riboswitch occurring in all three domains of life. Even tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c00099937d84ab34b4cce8039ad421
https://doi.org/10.1038/s41598-019-40875-1
https://doi.org/10.1038/s41598-019-40875-1
Autor:
Zhihua Wang, Ji-Dong Fu, Mauricio G. S. Costa, Thomas J. Hund, Isabelle Deschenes, Peter J. Mohler, Kenneth R. Laurita, Xiaoping Wan, Charline Fagnen, Xianyao Xu, Catherine Vénien-Bryan, Adrienne T. Dennis, Daniel Gratz, Dandan Yang, Emre Bektik
Publikováno v:
Circulation
Background: MicroRNAs (miRs) play critical roles in regulation of numerous biological events, including cardiac electrophysiology and arrhythmia, through a canonical RNA interference mechanism. It remains unknown whether endogenous miRs modulate phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9a8c972a41ee7ec327740383cf758a2
https://doi.org/10.1038/s41569-021-00540-5
https://doi.org/10.1038/s41569-021-00540-5